Person: Olmeda García, Ángeles Sonia
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First Name
Ángeles Sonia
Last Name
Olmeda García
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Veterinaria
Department
Sanidad Animal
Area
Sanidad Animal
Identifiers
20 results
Search Results
Now showing 1 - 10 of 20
Item Influence of environmental temperature and humidity on questing ticks in central Spain(Experimental and Applied Acarology, 2017) Requena García, F.; Cabrero Sañudo, Francisco José; Olmeda García, Ángeles Sonia; González, Julia; Valcárcel, F.Ticks are important ectoparasites and vectors of the pathogens that cause disease in humans and animals. At a natural reserve in Ciudad Real (Spain), an uncontrollable infestation of wild animals with Hyalomma lusitanicum (Koch) has been reported by some game reserve owners. Many questions about distribution, abundance, and phenology of this tick in this area remain unanswered. The aim of this study was to determine if temperature and relative humidity affect the questing tick’s activity in four species of ticks in a mesoMediterranean area, especially that of H. lusitanicum. Data for tick populations in six selected sampling sites every month, between January 2007 and December 2013 were used. Temperature and humidity values (ground and environmental) were recorded. The sampling effort, the similarity between sites, and the phenology of the species were analyzed. Effects of environmental variables on tick’s activity were assessed by general linear models (GLM) whereas the comparative importance of variables was measured by hierarchical variance partitioning. Hyalomma lusitanicum represented 96.3% of the four species of ticks collected. Spring and summer months presented a higher activity of ticks, than autumn and winter months. In general, humidity variables were negatively related to the activity of ticks, whereas temperature variables were positively related. Our results suggest that the highest activity in the area is produced by biological characteristics of H. lusitanicum; being temperature and humidity the most important environmental factors influencing the abundance of this species in the region.Item Acaricidal and Repellent Effects of Essential Oils against Ticks: A Review(Pathogens, 2021) Selles, Sidi Mohammed Ammar; Kouidri, Mokhtaria; González, Marta G.; González, Julia; Sánchez, María; González Coloma, Azucena; Sanchis, Jaime; Elhachimi, Latifa; Olmeda García, Ángeles Sonia; Tercero, José Maria; Valcárcel, FélixTick control is a priority in order to prevent the transmission of vector-borne diseases. Industrial chemical acaricides and repellents have been the most efficient tools against hard ticks for a long time. However, the appearance of resistances has meant the declining effectiveness of the chemicals available on the market. The trend today is to develop alternative control methods using natural products to replace nonefficient pesticides and to preserve the efficient ones, hoping to delay resistance development. Traditional in vitro evaluation of acaricidal activity or resistance to synthetic pesticides have been reviewed and they mainly focus on just one species, the one host tick (Rhipicephalus (Boophilus) microplus (Acari: Ixodidae)). Recent reports have called for the standardization of natural product components, extraction techniques, and experimental design to fully discover their acaricidal potential. This study reviews the main variables used in the bibliography about the efficiency of natural products against ticks, and it proposes a unification of variables relating to ticks, practical development of bioassays, and estimation of ixodicidal activity.Item Germacrone Derivatives as new Insecticidal and Acaricidal Compounds: A Structure-Activity Relationship(Molecules, 2019) Galisteo Pretel, Alberto; Pérez del Pulgar, Helena; Guerrero de León, Estela; López-Pérez, José Luis; Olmeda García, Ángeles Sonia; Gonzalez-Coloma, Azucena; F. Barrero, Alejandro; Quílez del Moral, José FranciscoCurrently, the use of synthetic pesticides is the main method of plant protection applied in agri- and horticulture. However, its excessive use leads to the development of pesticide resistance, a contamination of the environment, toxicity to non-target organisms, and risks for human health. With the ultimate aim of contributing to the develop of a more sustainable pest management, we used the natural product germacrone (compound 1), reported to possess significant insecticidal activity, as starting material for the generation of molecular diversity (2–24). Some of the generated derivatives are natural compounds, such as 1,10-epoxygermacrone (2), 4,5-epoxygermacrone (3), gajutsulactone A (7), germacrol (11), isogermacrone (14), 9-hydroxyeudesma-3,7(11)dien-6-one (19), eudesma-4,7(11),dien-8-one (20), eudesma-3,7(11)-dien-8-one (21) and eudesma-4(15),7(11)-dien-8-one (22). Compounds, 7,11-9,10-diepoxigermacr-4,5-en-8-ol (17), 7,11-epoxieudesma-4,7(11)-dien-8-one (23) and 7,11-epoxieudesma-3,7(11)-dien-8-one (24) are described for the first time. The biocidal activity of most of these compounds was assayed against the tick Hyalomma lusitanicum. The acaricidal effects of compound 24 were four times higher than that of germacrone (1). Compound 2 is an insect antifeedant a thousand times more potent than germacrone against Rhopalosiphum padi, which makes this substance a promising selective antifeedant against this cereal pest.- Project number: 175
Item ¿Qué parásito soy?: aprendizaje lúdico de la Parasitología mediante el empleo de pistas e imágenes(2020) Gómez Muñoz, María Teresa; Azami Conesa, Iris; Juan Ferré, Lucía De; Hernández Carrillo, Javier; Luzón Peña, Mónica; Martínez Díaz, Rafael Alberto; Olmeda García, Ángeles SoniaLa Parasitología emplea muchos conceptos, nombres, taxonomía e imágenes que complican el aprendizaje. Desarrollaremos una actividad basada en el juego para relacionar conceptos e imágenes, al tiempo que los alumnos evalúan su evolución de aprendizaje. La actividad se desarrollará en una página web. Item Alpha-Gal, epitope responsible for allergy to red meat, in the Mediterranean tick Hyalomma lusitanicum(Medical and Veterinary Entomology, 2024) Valcárcel Olmeda, Ángela; Briones Montero, Andrea; Rodero Martínez, Marta; González Fernández, Juan; Olmeda García, Ángeles Sonia; Valcárcel, Félix; Cuéllar Del Hoyo, María Del CarmenAlpha-Gal/α-Gal is an oligosaccharide produced by non-primate mammals. Humans have developed an immune response mediated by anti-α-Gal antibodies that can trigger an allergic reaction and cause anaphylaxis. In recent years, cases of patients with delayed allergic reaction to mammalian meat have been reported worldwide. In Spain, these cases have been related to the species Ixodes ricinus L. (Ixodida: Ixodidae), whose distribution is located in the north of the country. In this work, the presence of α-Gal in water-soluble extracts from samples of salivary glands and digestive tracts of Hyalomma lusitanicum Koch (Ixodida: Ixodidae) both engorged and collected from vegetation were studied. The presence of that epitope was confirmed by the presence of reactive proteins of >250 kDa in both samples. The highest concentrations of α-Gal were detected in salivary glands. Neither sex nor diet influenced the concentration of α-Gal, which seems to indicate its endogenous production and its possible inoculation to the host during tick feeding.- Project number: 56
Item Parásitos en movimiento: Videoteca docente(2023) Gómez Muñoz, María Teresa; Montoya Matute, Ana; Olmeda García, Ángeles Sonia; Juan Ferré, Lucía De; Azami Conesa, Iris; Barrera Martín, Juan Pedro; Carbonell Bonelo, Juan David; Hurtado Corral, Izaskum; Valcárcel Sancho, Félix; Meana Mañes, María Aranzazu Item Bioactive Metabolites from the Endophytic Fungus Aspergillus sp. SPH2(Journal of Fungi, 2021) Morales Sánchez, Viridiana; Díaz, Carmen E.; Trujillo, Elena; Olmeda García, Ángeles Sonia; Valcarcel, Felix; Muñoz, Rubén; Andrés, María Fe; González Coloma, AzucenaIn the current study, an ethyl acetate extract from the endophytic fungus Aspergillus sp. SPH2 isolated from the stem parts of the endemic plant Bethencourtia palmensis was screened for its biocontrol properties against plant pathogens (Fusarium moniliforme, Alternaria alternata, and Botrytis cinerea), insect pests (Spodoptera littoralis, Myzus persicae, Rhopalosiphum padi), plant parasites (Meloidogyne javanica), and ticks (Hyalomma lusitanicum). SPH2 gave extracts with strong fungicidal and ixodicidal effects at different fermentation times. The bioguided isolation of these extracts gave compounds 1–3. Mellein (1) showed strong ixodicidal effects and was also fungicidal. This is the first report on the ixodicidal effects of 1. Neoaspergillic acid (2) showed potent antifungal effects. Compound 2 appeared during the exponential phase of the fungal growth while neohydroxyaspergillic acid (3) appeared during the stationary phase, suggesting that 2 is the biosynthetic precursor of 3. The mycotoxin ochratoxin A was not detected under the fermentation conditions used in this work. Therefore, SPH2 could be a potential biotechnological tool for the production of ixodicidal extracts rich in mellein.Item Novel Insect Antifeedant and Ixodicidal Nootkatone Derivatives(Biomolecules, 2019) Galisteo Pretel, Alberto; Pérez del Pulgar, Helena; Olmeda García, Ángeles Sonia; Gonzalez-Coloma, Azucena; Barrero, Alejandro F.; Quílez del Moral, José FranciscoNaturally occurring nootkatone, with reported insecticidal and acaricidal properties, has been used as a lead to generate molecular diversity and, consequently, new insect antifeedant and ixodicidal compounds. A total of 22 derivatives were generated by subjecting this molecule to several reactions including dehydrogenation with the iodine/DMSO system, oxidation with SeO2, epoxidation with mCPBA, oxidation or carbon homologations of the α-carbonyl position with TMSOTf (trimethylsilyl trifluoromethanesulfonate) followed by Rubottom and Dess Martin periodane oxidations, condensation with formaldehyde using Yb(OTf)3 as catalyst and dehydroxilation using the Grieco protocol. The insect antifeedant (against Myzus persicae and Ropaloshysum padi) and ixodicidal (against the tick Hyalomma lusitanicum) activities of these compounds were tested. Compound 20 was the most active substance against M. persicae and R. padi, and twice more efficient than nootkatone in the antitick test.- Project number: 103
Item Veterinaria es calidad: Plan de difusión de nuevos sistemas de evaluación. Análisis de los títulos del Centro(2019) Olmeda García, Ángeles Sonia; Pérez Cabal, María De Los Ángeles; San Andrés Larrea, María Dolores De; Barrero Rodríguez, Andrés; Cambero Rodríguez, María Isabel; Sainz Rodríguez, Ángel; Gómez Muñoz, María Teresa; Pérez Sen, Raquel; Lorenzo González, Pedro LuisEl informe recoge los datos más relevantes de los logros alcanzados en el proyecto, como son el análisis de la satisfacción de las asignaturas con el Grado en Veterinaria; la formación de los docentes en nuevas tecnologías y evaluación por rúbrica y su aplicación en la actividad diaria; la organización de Jornadas de Innovación Docente en Veterinaria; Presentación de la experiencia del centro en temas de calidad en el Congreso Internacional de Innovación Educativa en Ciencias Agrarias, Universidad de la Molina, Lima (2018). Item Antiparasitic Properties of Cantharidin and the Blister Beetle Berberomeloe majalis (Coleoptera: Meloidae)(Toxins, 2019) Whitman, Douglas W.; Andrés, Maria Fe; Martínez Díaz, Rafael A; Ibáñez Escribano, Alexandra; Olmeda García, Ángeles Sonia; Gonzalez-Coloma, AzucenaCantharidin (CTD) is a toxic monoterpene produced by blister beetles (Fam. Meloidae) as a chemical defense against predators. Although CTD is highly poisonous to many predator species, some have evolved the ability to feed on poisonous Meloidae, or otherwise beneficially use blister beetles. Great Bustards, Otis tarda, eat CTD-containing Berberomeloe majalis blister beetles, and it has been hypothesized that beetle consumption by these birds reduces parasite load (a case of self-medication). We examined this hypothesis by testing diverse organisms against CTD and extracts of B. majalis hemolymph and bodies. Our results show that all three preparations (CTD and extracts of B. majalis) were toxic to a protozoan (Trichomonas vaginalis), a nematode (Meloidogyne javanica), two insects (Myzus persicae and Rhopalosiphum padi) and a tick (Hyalomma lusitanicum). This not only supports the anti-parasitic hypothesis for beetle consumption, but suggests potential new roles for CTD, under certain conditions.