Person:
Casals Carro, María Jesús

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First Name
María Jesús
Last Name
Casals Carro
URI
https://hdl.handle.net/20.500.14352/82854
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Ciencias de la Informacion
Department
Area
Periodismo
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2002 - 200912010 - 20121
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    Los cien primeros años de la Universidad Complutense y su influencia educativa en la política española (1836-1956)
    (2002) Casals Carro, María Jesús; Martínez Albertos, José Luis
    El periodismo de investigación utiliza archivos y fuentes documentales para elaborar sus diversos trabajos y ficheros. La tesis parte de esta base y elabora un documento que trata de probar la influencia educativa de la universidad Complutense en la política española desde dos perspectiva: a) la cuantificativa: n de ministros y presidentes de gobierno que se han formado en ella y los que han pertenecido a su claustro de profesores; b) la cualitativa: análisis de las ideas, hechos, logros, fracasos y contradicciones que la universidad ha aportado a la vida política española. El tiempo de acotación es de cien años (1836-1936) y la nomina resultante es de 678 políticos censados. La tesis presenta tres tomos: 1 desarrollo del tema propuesto con sus conexiones históricas; 2 apéndice cronológico de todos los gobiernos y apéndice alfabético de todos los nombres con las indicaciones pertinentes; 3 apéndice biográfico de los 678 políticos con los datos biográficos fundamentales y especificación de la clase y lugar de estudios.
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    The interplay of lung surfactant proteins and lipids assimilates the macrophage clearance of nanoparticles
    (PLoS One, 2012) Ruge, C.A.; Schaefer, U.F.; Herrmann, J.; Kirch, J.; Cañadas Benito, Olga; Echaide Torreguitar, Mercedes; Pérez Gil, Jesús; Casals Carro, María Jesús; Müller, R.; Lehr, C.M.
    The peripheral lungs are a potential entrance portal for nanoparticles into the human body due to their large surface area. The fact that nanoparticles can be deposited in the alveolar region of the lungs is of interest for pulmonary drug delivery strategies and is of equal importance for toxicological considerations. Therefore, a detailed understanding of nanoparticle interaction with the structures of this largest and most sensitive part of the lungs is important for both nanomedicine and nanotoxicology. Astonishingly, there is still little known about the bio-nano interactions that occur after nanoparticle deposition in the alveoli. In this study, we compared the effects of surfactant-associated protein A (SP-A) and D (SP-D) on the clearance of magnetite nanoparticles (mNP) with either more hydrophilic (starch) or hydrophobic (phosphatidylcholine) surface modification by an alveolar macrophage (AM) cell line (MH-S) using flow cytometry and confocal microscopy. Both proteins enhanced the AM uptake of mNP compared with pristine nanoparticles; for the hydrophilic ST-mNP, this effect was strongest with SP-D, whereas for the hydrophobic PL-mNP it was most pronounced with SP-A. Using gel electrophoretic and dynamic light scattering methods, we were able to demonstrate that the observed cellular effects were related to protein adsorption and to protein-mediated interference with the colloidal stability. Next, we investigated the influence of various surfactant lipids on nanoparticle uptake by AM because lipids are the major surfactant component. Synthetic surfactant lipid and isolated native surfactant preparations significantly modulated the effects exerted by SP-A and SP-D, respectively, resulting in comparable levels of macrophage interaction for both hydrophilic and hydrophobic nanoparticles. Our findings suggest that because of the interplay of both surfactant lipids and proteins, the AM clearance of nanoparticles is essentially the same, regardless of different intrinsic surface properties.