Person: Rodríguez López, Juan Pedro
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First Name
Juan Pedro
Last Name
Rodríguez López
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Ciencias Geológicas
Department
Area
Estratigrafía
Identifiers
7 results
Search Results
Now showing 1 - 7 of 7
Item Differences in Nutritional Status and Inflammatory Biomarkers between Female and Male Patients with Bronchiectasis: A Large-Cohort Study(Biomedicines, 2021) Wang, Xuejie; Villa, Carmen; Dobarganes, Yadira; Olveira, Casilda; Girón, Rosa; García Clemente, Marta; Maíz, Luis; Sibila, Oriol; Golpe, Rafael; Menéndez, Rosario; Rodríguez López, Juan Pedro; Prados, Concepción; Martinez García, Miguel Angel; Rodríguez Hermosa, Juan Luis; de la Rosa, David; Duran, Xavier; Barreiro, EstherWe hypothesized that systemic inflammatory and nutritional parameters may differ between male and female patients with non-CF bronchiectasis. In a large patient cohort from the Spanish Online Bronchiectasis Registry (RIBRON), clinical features, systemic inflammatory and nutritional parameters were analyzed in male and female patients with bronchiectasis. Lung function, disease severity using several scores, nutritional status, systemic inflammatory parameters, and multivariate regression analyses were performed to identify differences between male and female patients in the target variables. The number of female patients included in the registry was greater than male patients and they had a less severe disease as measured by all three indices of disease severity, a lower degree of airway obstruction, worse diffusion capacity and airway trapping, better nutritional parameters, and lower levels of inflammatory biomarkers. Multivariate regression analysis evidenced that strong relationships were found between female gender and the following variables: total numbers of leukocytes and neutrophils, hemoglobin, hematocrit, creatinine, and body mass index (BMI). Multivariate regression analyses evidenced that nutritional parameters and inflammatory biomarkers may be reliable indicators of gender-related differences in patients with non-CF bronchiectasis. These findings deserve further attention in follow-up investigations in which the potential predictive value of those biomarkers should be thoroughly explored.Item Blood Neutrophil Counts Define Specific Clusters of Bronchiectasis Patients: A Hint to Differential Clinical Phenotypes(Biomedicines, 2022) Wang, Xuejie; Olveira, Casilda; Girón, Rosa; García Clemente, Marta; Máiz, Luis; Sibila, Oriol; Golpe, Rafael; Menéndez, Rosario; Rodríguez López, Juan Pedro; Prados, Concepción; Martinez García, Miguel Angel; Rodriguez Hermosa, Juan Luis; Rosa, David de la; Qin, Liyun; Duran, Xavier; Garcia Ojalvo, Jordi; Barreiro, EstherWe sought to investigate differential phenotypic characteristics according to neutrophil counts, using a biostatistics approach in a large-cohort study from the Spanish Online Bronchiectasis Registry (RIBRON). The 1034 patients who met the inclusion criteria were clustered into two groups on the basis of their blood neutrophil levels. Using the Mann–Whitney U test to explore potential differences according to FACED and EFACED scores between the two groups, a neutrophil count of 4990 cells/µL yielded the most balanced cluster sizes: (1) above-threshold (n = 337) and (2) below-threshold (n = 697) groups. Patients above the threshold showed significantly worse lung function parameters and nutritional status, while systemic inflammation levels were higher than in the below-threshold patients. In the latter group, the proportions of patients with mild disease were greater, while a more severe disease was present in the above-threshold patients. According to the blood neutrophil counts using biostatistics analyses, two distinct clinical phenotypes of stable patients with non-CF bronchiectasis were defined. Patients falling into the above-threshold cluster were more severe. Severity was characterized by a significantly impaired lung function parameters and nutritional status, and greater systemic inflammation. Phenotypic profiles of bronchiectasis patients are well defined as a result of the cluster analysis of combined systemic and respiratory variables.Item Systemic Inflammatory Biomarkers Define Specific Clusters in Patients with Bronchiectasis: A Large-Cohort Study(Biomedicines, 2022) Wang, Xuejie; Villa, Carmen; Dobarganes, Yadira; Olveira, Casilda; Girón, Rosa; García Clemente, Marta; Máiz, Luis; Sibila, Oriol; Golpe, Rafael; Menéndez, Rosario; Rodríguez López, Juan Pedro; Prados, Concepción; Martinez García, Miguel Angel; Rodriguez Hermosa, Juan Luis; Rosa, David de la; Duran, Xavier; Garcia Ojalvo, Jordi; Barreiro, EstherDifferential phenotypic characteristics using data mining approaches were defined in a large cohort of patients from the Spanish Online Bronchiectasis Registry (RIBRON). Three differential phenotypic clusters (hierarchical clustering, scikit-learn library for Python, and agglomerative methods) according to systemic biomarkers: neutrophil, eosinophil, and lymphocyte counts, C reactive protein, and hemoglobin were obtained in a patient large-cohort (n = 1092). Clusters #1–3 were named as mild, moderate, and severe on the basis of disease severity scores. Patients in cluster #3 were significantly more severe (FEV1, age, colonization, extension, dyspnea (FACED), exacerbation (EFACED), and bronchiectasis severity index (BSI) scores) than patients in clusters #1 and #2. Exacerbation and hospitalization numbers, Charlson index, and blood inflammatory markers were significantly greater in cluster #3 than in clusters #1 and #2. Chronic colonization by Pseudomonas aeruginosa and COPD prevalence were higher in cluster # 3 than in cluster #1. Airflow limitation and diffusion capacity were reduced in cluster #3 compared to clusters #1 and #2. Multivariate ordinal logistic regression analysis further confirmed these results. Similar results were obtained after excluding COPD patients. Clustering analysis offers a powerful tool to better characterize patients with bronchiectasis. These results have clinical implications in the management of the complexity and heterogeneity of bronchiectasis patients.Item Giant calcite concretions in aeolian dune sandstones; sedimentological and architectural controls on diagenetic heterogeneity, mid-Cretaceous Iberian Desert System, Spain(Sedimentary Geology, 2012) Arribas Mocoroa, María Eugenia; Rodríguez López, Juan Pedro; Meléndez Hevia, María Nieves; Soria de Miguel, Ana Rosa; De Boer, PoppeAeolian dune sandstones of the Iberian erg system (Cretaceous, Spain) host giant calcite concretions that constitute heterogeneities of diagenetic origin within a potential aeolian reservoir. The giant calcite concretions developed in large-scale aeolian dune foresets, at the transition between aeolian dune toeset and damp interdune elements, and in medium-scale superimposed aeolian dune sets. The chemical composition of the giant concretions is very homogeneous. They formed during early burial by lowMg-calcite precipitation frommeteoric pore waters. Carbonate componentswith yellow/orange luminescence form the nuclei of the poikilotopic calcite cement. These cements postdate earlier diagenetic features, characterized by earlymechanical compaction, Fe-oxide cements and clay rims around windblown quartz grains resulting from the redistribution of aeolian dust over the grain surfaces. The intergranular volume (IGV) in friable aeolian sandstone ranges from 7.3 to 15.3%, whereas in cemented aeolian sandstone it is 18.6 to 25.3%. The giant-calcite concretions developed during early diagenesis under the influence of meteoric waters associated with the groundwater flow of the desert basin, although local (e.g. activity of fluid flow through extensional faults) and/or other regional controls (e.g. variations of the phreatic level associated with a variable water influx to the erg system and varying sea level) could have favoured the local development of giant-calcite concretions. The spatial distribution pattern of carbonate grains and the main bounding surfaces determined the spatial distribution of the concretions. In particular, the geometry of the giant calcite concretions is closely associated with main bounding aeolian surfaces. Thus, interdune, superimposition and reactivation surfaces exerted a control on the concretion geometries ranging fromflat and tabular ones (e.g. bounded by interdunes) towedge-shaped concretions at the dune foresets (e.g. bounded by superimposition and reactivation surfaces) determining the spatial distribution of the heterogeneities of diagenetic origin in the aeolian reservoir.Item Palynology of Aptian and upper Albian (Lower Cretaceous) amber-bearing outcrops of the southern margin of the Basque-Cantabrian basin (northern Spain)(Cretaceous Research, 2015) Barrón López, Eduardo; Daniel Peyrot, Daniel; Rodríguez López, Juan Pedro; Meléndez Hevia, María Nieves; López del Valle, Rafael; Najarro, María; Rosales, Idoia; Comas Rengifo, María JoséThe Lower Cretaceous deposits of the southern margin of the Basque-Cantabrian basin (northern Spain) are characterised by continental deposits interbedded with amber-bearing marine-influenced facies. These facies crop out in various localities and have yielded well-preserved palynological assemblages. The palynoflora is dominated by gymnosperm pollen grains, and shows relatively diversified spore content but scarce dinoflagellate cysts. The palynofloral evidence and regional geological setting indicate that the studied successions are dated as Aptian (Montoria-La Mina outcrop) and late Albian (Peñacerrada 1 and 2 and Salinillas de Buradón outcrops, and the Pancorbo site). Angiosperm pollen does not constitute a significant part of the Aptian assemblages but becomes diversified and numerically abundant in those dated as late Albian. Although broadly similar to contemporaneous palynofloras from eastern Spain, the Aptian assemblages of Montoria-La Mina do not yield tricolpate angiosperm pollen. Conversely, the inferred late Albian assemblages show a high content in polyaperturate angiosperm pollen grains, as occurs in other localities in Portugal, Western Europe and North America. The studied palynoflora shows significant differences from published assemblages located further north, in western France and Canada.Item Glacial dropstones in the western Tethys during the late Aptian–early Albian cold snap: Palaeoclimate and palaeogeographic implications for the mid-Cretaceous(Palaeogeography, Palaeoclimatology, Palaeoecology, 2016) Rodríguez López, Juan Pedro; Liesa, Carlos L.; Pardo, Gonzalo; Meléndez Hevia, María Nieves; Soria, Ana R.; Skilling, IanThe late Jurassic–early Cretaceous is commonly considered the only cold climatic interval in Earth history without any direct evidence of polar ice. A newly discovered dropstone-bearing interval from the subtropical Iberian Basin (western Tethys) is described and provides evidence of contemporaneous polar glaciation. This interval is correlated laterally for 4.8 km and contains a boulder and two cobble-sized quartzite dropstones that are encased in mid-Cretaceous fissile black shales and fine-grained sandstones. Based on previously published dimensions of similar large clasts, only glacial dropstones and impact ejecta blocks reach the dimensions of the boulder-sized dropstone reported from Iberia. The dropstones show morphological features compatible with glacial transport and abrasion in a subglacial setting which closely resembles the features observed in recent glacial boulders exposed near the snouts of glaciers in Iceland. These Late Aptian dropstones from Spain correlate with many other similar erratics in the northern and southern palaeohemispheres, and suggest that ice sheets formed around the palaeo-North Pole during certain periods of the early Cretaceous. Our results and associated evidence such as the occurrence of glendonites, tillites, moderate- to high-amplitude sea-level oscillations worldwide, minimum pCO2 concentrations, variation in calcareous nannofossil assemblages from low and high latitudes and isotopic excursions suggest that during the mid-Cretaceous there were periods of ice growth and decay that influenced the palaeotemperature, palaeoecology and sedimentology of the marine realm. The new data from Iberia are supported by recent results from Arctic Canada that indicate cool shelves and a mid-Cretaceous cold snap that developed for ~6 Myr between 118 and 112 Ma. The late Aptian dropstones reported in eastern Iberia were likely transported from high northern latitudes towards subtropical ones in the western Tethys by an extreme iceberg drift similar to those occurring at the present day in the Atlantic Ocean. Icebergs released from a northern fringing ice sheet may have travelled southwards through the Greenland–Norwegian Seaway.Item Scouring by rafted ice and cryogenic patterned ground preserved in a Palaeoproterozoic equatorial proglacial lagoon succession, eastern India, Nuna supercontinent(Marine and Petroleum Geology, 2021) Rodríguez López, Juan Pedro; Van Vliet-Lanoë, Brigitte; López Martínez, Jerónimo; Martín García, RebecaThe Chaibasa Formation contains the oldest known record of ploughmarks formed by rafted ice preserved on Earth. The Palaeoproterozoic (Orosirian-Rhyacian, 1.86–2.1 Ga) Chaibasa Formation in the Dhalbhumgarh area, eastern India, represents sedimentation in an ice-contact proglacial lagoon affected by iceberg (bits and growlers) calving and lake-ice rafting. Ice scouring, both on muddy and sandy substrates, as well as ice “rosettes” developed as consequence of the ploughing action of floating icebergs that were moved by wind, meltwater floods and tidal currents on soft sediments. Muddy flats surrounding the proglacial lagoon underwent seasonal deep freezing conditions developing cryogenic patterned ground containing reticulate ice, ice veins and sand wedges, suggesting the occurrence of proglacial permafrost areas coeval with Proterozoic glaciers. The central part of the proglacial lagoon was characterized by deposition of glacial varves punctuated by pebble and cobble size angular dropstones accumulated in the basin as ice-rafted debris from floating ice. Evidences provided in this paper reinforced the idea that 1.86–2.1 Ga ago glacial conditions prevailed after the supposed ending of the Huronian glaciation. This paper provides detailed examples that can be used to recognize possible floating/drifted ice scours in other Precambrian successions, as these elements have largely passed undetected, being probably widely reported in the literature as generic soft-sediment deformation structures. Similar soft-sediment deformations from Precambrian clastic depositional systems should be re-evaluated as there is a significant possibility that most of the Precambrian iceberg-related structures had escape notice, as originally suggested Eyles et al. in 1997.