Person:
Vicente López, María Ángeles

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First Name
María Ángeles
Last Name
Vicente López
URI
https://hdl.handle.net/20.500.14352/79596
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Medicina
Department
Biología Celular
Area
Biología Celular
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    Unveiling the value of C-reactive Protein as a Severity Biomarker and the IL4/IL13 Pathway as a Therapeutic Target in Recessive Dystrophic Epidermolysis Bullosa: a multiparametric cross-sectional study
    (Experimental Dermatology, 2024) Quintana Castanedo, Lucía; Sánchez Ramón, Silvia María; Illera, Nuria; Zuluaga Arias, María Del Pilar; Martínez Santamaría, Lucía; Fernández Arquero, Miguel; Río, Marcela del; Vicente López, María Ángeles; Escámez, María José; Sacedón Ayuso, Rosa
    Patients with recessive dystrophic epidermolysis bullosa (RDEB) experience numerous complications, which are exacerbated by inflammatory dysregulation and infection. Understanding the immunological mechanisms is crucial for selecting medications that balance inflammation control and immunocompetence. In this cross-sectional study, aiming to identify potential immunotherapeutic targets and inflammatory biomarkers, we delved into the interrelationship between clinical severity and systemic inflammatory parameters in a representative RDEB cohort. Encompassing 84 patients aged 1 to 67 and spanning all three Epidermolysis Bullosa Disease Activity and Scarring Index (EBDASI) severity categories, we analyzed the interrelationship of infection history, standard inflammatory markers, systemic cytokines, and Ig levels to elucidate their roles in RDEB pathophysiology. Our findings identify C-reactive protein as an excellent biomarker for disease severity in RDEB. A Type 2 inflammatory profile prevails among moderate and severe RDEB patients, correlating with dysregulated circulating IgA and IgG. These results underscore the IL4/IL13 pathways as potential evidence-based therapeutic targets. Moreover, the complete inflammatory scenario aligns with Staphylococcus aureus virulence mechanisms. Concurrently, abnormalities in IgG, IgE, and IgM levels suggest an immunodeficiency state in a substantial number of the cohort's patients. Our results provide new insights into the interplay of infection and immunological factors in the pathogenesis of RDEB.