Person:
Encinas Cerezo, María Teresa

First Name

María Teresa

Last Name

Encinas Cerezo

URI

https://hdl.handle.net/20.500.14352/80368

Affiliation

Universidad Complutense de Madrid

Faculty / Institute

Veterinaria

Department

Farmacología y Toxicología

Area

Farmacología

Identifiers

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Search Results

Now showing 1 - 10 of 24

Polyphenols and IUGR Pregnancies: Effects of Maternal Hydroxytyrosol Supplementation on Placental Gene Expression and Fetal Antioxidant Status, DNA-Methylation and Phenotype
(International Journal of Molecular Sciences, 2019) Garcia-Contreras, Consolación; Vázquez Gómez, Marta; Barbero, Alicia; Pesantez, José; Zinellu, Angelo; Berlinguer, Fiammetta; González Añover, Pedro; Gonzalez, Jorge; Encinas Cerezo, María Teresa; Torres-Rovira, Laura; Nuñez, Yolanda; Ballesteros, Jaime; Ayuso, Miriam; Astiz, Susana; Isabel Redondo, Beatriz; Ovilo, Cristina; González Bulnes, Antonio
The use of polyphenols is a promising strategy for preventing or alleviating intrauterine growth restriction (IUGR) because polyphenol supplementation increases plasma antioxidant capacity and improves oxidative stress at the feto-placental unit; which are recognized as main issues in IUGR. However, there is a scarcity of experimental data on both realistic benefits and potential hazards of polyphenol supplementation during gestation. Hence, we aimed to use a swine model of IUGR pregnancy to determine possible effects of maternal supplementation with polyphenols (hydroxytyrosol) on placental expression of genes involved in antioxidant homeostasis, vascularization and fetal growth and thus on antioxidant status, DNA-methylation and phenotypic traits (morphology and homeostasis) of the fetus. Hydroxytyrosol improves placental gene expression and fetal antioxidant status and glucose metabolism in a sex-dependent manner, in which males were favored in spite of developmental failures. Concomitantly, hydroxytyrosol prevented hypomethylation of DNA associated with oxidative stress. Finally, no major deleterious effects of hydroxytyrosol supplementation on constriction of the ductus arteriosus, a possible secondary effect of polyphenols during pregnancy, were found.
El seminario de trabajo en el Campus Virtual UCM: una herramienta para actividades de investigación en grupo
(VI Jornada Campus Virtual UCM: Campus Virtual crece: retos del EEES y oportunidades para la UCM, 2011) Gilabert Santos, Juan Antonio; Ros Rodríguez, José María; Díez Delgado, Iratxe; Rojo Solís, Carlos; Encinas Cerezo, María Teresa
Los proyectos de investigación cuyos resultados son de utilidad por su aplicabilidad clínica necesitan de herramientas de comunicación eficaces. Por otra parte, la organización de un grupo numeroso de personas requiere de herramientas que optimicen tanto el tiempo como las tareas a realizar. Además, la participación coral en la discusión y elaboración de los resultados enriquece la investigación y culmina el espíritu colaborativo del trabajo de un equipo. Éstos han sido los objetivos que se perseguían al organizar el Seminario de Investigación sobre Terapéutica de Animales Exóticos (SITAE) en el Campus Virtual de la UCM. Esta herramienta nos ha sido de gran ayuda en la organización, consulta, generación de materiales y difusión de los resultados derivados del citado proyecto de investigación. La presente comunicación pretende mostrar la utilidad de los seminarios de trabajo en el Campus Virtual UCM (CV-UCM) como herramienta de apoyo al trabajo en un proyecto de investigación de tipo colaborativo en el que participan distintos profesionales con diferentes localizaciones geográficas.
Project number: 244
Elaboración y desarrollo de materiales accesibles para la formación de jóvenes con discapacidad intelectual en la atención y cuidado de animales, mediante la intervención en el Proyecto Liceo
(2022) Encinas Cerezo, María Teresa; Pablo Moreno, Juan Andrés de; Águeda Gómez, Alejandra de; De Las Heras Molina, Ana; Fernández Bravo, Juan Antonio; Fernández de Lys Galván, Gonzalo; Fuertes Recuero, Manuel; Gilabert Santos, Juan Antonio; Marín García, María Del Pilar; Morón Elorza, Pablo; Nieto González, David; Olivos Ore, Luis Alcides; Ortega Moreno, Carlos; Barbacid Yela, Andrea; Maqueda Olivas, Clara María; Arribas Blázquez, Marina; Díez Martín, Amalia
Profesionales especializados en Veterinaria y Educación Especial desarrollarán materiales cognitivamente accesibles para jóvenes con discapacidad intelectual aplicables a los contenidos del itinerario de Cuidado de Animales del Proyecto Liceo.
Maternal Supplementation with Polyphenols and Omega-3 Fatty Acids during Pregnancy: E ects on Growth, Metabolism, and Body Composition of the O spring
(ANIMALS, 2020) De Las Heras Molina, Ana; Pesantez-Pacheco, José Luis; Astiz, Susana; Garcia-Contreras, Consolación; Vázquez Gómez, Marta; Encinas Cerezo, María Teresa; Óvilo, Cristina; Isabel Redondo, Beatriz; Gonzalez-Bulnes, Antonio; Isabel Redondo, Beatriz
Maternal supplementation with antioxidants and n3 PUFAs may be a promising strategy to reduce the risk of intrauterine growth restriction and preterm delivery, which may diminish the appearance of low-birth-weight neonates. The present study aimed to determine benefits and risks of a dietary supplementation combining hydroxytyrosol, a polyphenol from olive leaves and fruits, and n3 PUFAs, from linseed oil, on developmental patterns and metabolic traits of offspring in swine, a model of IUGR pregnancies. The results obtained indicate that maternal supplementation with hydroxytyrosol and n-3 fatty acids during pregnancy has no deleterious effects on the reproductive traits of the sows (prolificacy, homogeneity of the litter, and percentage of stillborns and low-birth-weight, LBW, piglets) and the postnatal features of the piglets (growth patterns, adiposity, and metabolic traits). Conversely, in spite of a lower mean weight and corpulence at birth, piglets from the supplemented sows showed higher average daily weight gain and fractional growth rate. Thus, at juvenile stages afterwards, the offspring from the treated group reached higher weight and corpulence, with increased muscle development and better lipidemic and fatty acid profiles, in spite of similar adiposity, than offspring in the control group. However, much caution and more research are still needed before practical recommendation and use in human pregnancies.
Polyphenols and IUGR Pregnancies: Effects of Maternal Hydroxytyrosol Supplementation on Hepatic Fat Accretion and Energy and Fatty Acids Profile of Fetal Tissues
(Nutrients, 2019) Garcia-Contreras, Consolación; Vázquez Gómez, Marta; Pardo, Zaira; De Las Heras Molina, Ana; Pesantez, José Luis; Encinas Cerezo, María Teresa; Torres-Rovira, Laura; Astiz, Susana; Nieto, Rosa; Ovilo, Cristina; González Bulnes, Antonio; Isabel Redondo, Beatriz
Maternal supplementation with hydroxytyrosol, a polyphenol present in olive leaves and fruits, is a highly promising strategy to improve the oxidative and metabolic status of fetuses at risk of intrauterine growth restriction, which may diminish the appearance of low-birth-weight neonates. The present study aimed to determine whether hydroxytyrosol, by preventing lipid peroxidation, may influence the fat accretion and energy homeostasis in the liver, as well as the fatty acid composition in the liver and muscle. The results indicate that hydroxytyrosol treatment significantly decreased the energy content of the fetal liver, without affecting fat accretion, and caused significant changes in the availability of fatty acids. There were significant increases in the amount of total polyunsaturated fatty acids, omega-3 and omega-6, which are highly important for adequate fetal tissue development. However, there were increases in the omega-6/omega-3 ratio and the desaturation index, which make further studies necessary to determine possible effects on the pro/anti-inflammatory status of the fetuses.
Pharmacokinetics of meloxicam during multiple oral or intramuscular dose administration to African grey parrots (Psittacus erithacus)
(American Journal of Veterinary Research, 2019) Montesinos Barceló, Andrés; Encinas Cerezo, María Teresa; Ardiaca, María; Gilabert Santos, Juan Antonio; Bonvehí, Cristina; Orós, Jorge
Abstract OBJECTIVE To determine the pharmacokinetics of meloxicam in African grey parrots (Psittacus erithacus) during administration of multiple doses. ANIMALS 6 healthy African grey parrots. PROCEDURES Meloxicam was administered at each of 3 dosages (1 mg/kg, IM, q 24 h, for 7 days; 1 mg/kg, PO, q 24 h, for 12 days; and 1.6 mg/kg, PO, q 24 h, for 7 days) with an 8-week washout period between treatments. Blood samples were collected 12 and 24 hours after each drug administration (times of presumptive peak and trough drug concentrations) for pharmacokinetic analysis. Birds were visually assessed during all experiments and monitored for changes in selected plasma and urine biochemical variables after administration of the drug at 1.6 mg/kg. RESULTS Mean trough plasma concentrations at steady state were 10.7 and 9.16 µg/ mL after meloxicam administration at 1 mg/kg, IM, and 1 mg/kg, PO, respectively. Plasma drug accumulation was evident (accumulation ratios of 2.04 ± 0.30 [IM treatment] and 2.45 ± 0.26 [PO treatment]). Plasma and urine N-acetyl-β- D -glucosaminidase activities were significantly increased at the end of meloxicam treatment at 1.6 mg/kg. CONCLUSIONS AND CLINICAL RELEVANCE Plasma concentrations of meloxicam were maintained at values greater than effective analgesic concentrations described for other avian species. Although administration of meloxicam at a dosage of 1 mg/kg IM and PO daily for 1 week and 12 days, respectively, was not associated with adverse clinical effects in this population, further studies are needed to assess the efficacy and safety of the drug during prolonged treatment and the clinical relevance of its accumulation.
Método para obtener células troncales neurales y células progenitoras neurales a partir de tejido cortical ovárico no embrionario
(2017) Aranda Espinosa, Pedro José; Galicia Guerrero, María Lourdes; Picazo González, Rosa Ana; Rojo Salvador, Concepción; Sánchez Maldonado, María Belén; García Palencia, María Del Pilar; Sánchez Pérez, María De Los Ángeles; Ros Rodríguez, José María; Gilabert Santos, Juan Antonio; Encinas Cerezo, María Teresa; UNIVERSIDAD COMPLUTENSE DE MADRID
Método para obtener células troncales neurales y células progenitoras neurales a partir de tejido cortical ovárico no embrionario. La presente invención se refiere a un método para obtener células troncales neurales y células progenitoras neurales (CTN/CPN) a partir de tejido cortical ovárico de hembras prepúberes de mamífero, sin necesidad de añadir al medio de cultivo factores de inducción y/o expansión del linaje neural. Con el método de la invención se obtienen CTN/CPN tras 6- 21 días de incubación, mejorando los resultados mediante la adición de FSH al medio de cultivo. Las CTN/CPN que se obtienen mediante este método pueden ser utilizadas en modelos experimentales de neurogénesis in vitro, en diferenciación dirigida de CTN/CPN para generar diversos tipos de células nerviosas de interés en medicina regenerativa del sistema nervioso, con aplicación al trasplante autólogo en terapia celular de patologías neurodegenerativas, así como para la evaluación de neurotoxicidad de diversos fármacos, contaminantes y compuestos químicos.
CUIDADO DE UN NÚCLEO DE GALLINAS EN PELIGRO DE EXTINCIÓN POR LOS ESTUDIANTES DEL DIPLOMA FORMATIVO UNIVERSITARIO LICEO-ESPECIALIDAD DE CUIDADO DE ANIMALES (GALLICEO)
(2023) Ortega Moreno,Carlos; Fernandez de Lis, Gonzalo; de Águeda, Alejandra; Fuente Vázquez, Jesús De La; Díaz Díaz Chirón, María Teresa; Cabezas Albéniz, Almudena; Olivares Moreno, Álvaro; Pineda González, Stefania; Rebolé Garrigós, Almudena; González De Chávarri Echániz, Elisabeth; Ortiz Vera, Luis Tomás; Escudero Portugués, Rosa María; Bermejo Poza, Rubén; Viveros Montoro, Agustín; Arija Martín, Ignacio; Castro Madrigal, Teresa; Laviano Medina, Hernán Darío; García Álvarez, Andrés; Salazar Hijosa, Raúl; Martín Amores, Ruth; Díez Romera, Mariano; Bonel Ayuso, Diego Paul; Encinas Cerezo, María Teresa; Alcides Olivos-Oré, Luis; Arribas Blázquez, Marina; Gilabert Santos, Juan Antonio; Morón Elorza, Pablo; Manso Alonso, Teresa; de las Heras Molina,Ana; Isabel Redondo, Beatriz
Pharmacokinetics of the analgesic and anti-inflammatory drug meloxicam after administration of multiple doses to nursehound sharks (Scyliorhinus stellaris)
(Veterinary Anaesthesia and Analgesia, 2023) Morón Elorza, Pablo; Rojo Solís, Carlos; Álvaro Álvarez, Teresa; Valls Torres, Mónica; García Párraga, Daniel; Encinas Cerezo, María Teresa
Objective: To determine the pharmacokinetics of meloxicam in the nursehound shark (Scyliorhinus stellaris) during multiple dose administration. Study design: Prospective experimental trial. Animals: A total of eight clinically healthy adult nursehounds (four males, four females). Methods: Meloxicam was administered intramuscularly at a dose of 1.5 mg kg–1 once daily for 7 days. Blood samples were collected from the caudal vein for pharmacokinetic analysis at 2.5 hours and 24 hours after drug administration. After a 4 week washout period, meloxicam was administered orally at the same dose at 12 hour intervals for three repeated doses. Blood samples were collected at 1, 2, 4, 6, 8, 12, 24, 36 and 48 hours after the first administration. Sharks were visually monitored during each study and 4 weeks afterwards for side effects or signs of toxicity. Time required to achieve steady state was assessed by visual inspection and statistical comparison of peak and trough concentrations using a Friedman test; comparison between sexes was performed using a Mann–Whitney U test and p-value was set at 0.05. Results: No animal died or showed clinical signs of toxicity during the study. Meloxicam administered orally did not produce detectable concentrations in plasma. After intramuscular administration, steady state was achieved after five doses, and mean trough and peak plasma concentrations at steady state were 1.76 ± 0.21 μg mL–1 and 3.02 ± 0.23 μg mL–1, respectively. Mean peak concentration accumulation ratio was 2.50 ± 0.22. Conclusions and clinical relevance: This study shows that intramuscular posology produces plasma concentrations considered therapeutic for other species. However, meloxicam was not detected in plasma after oral administration. These results suggest that meloxicam administered intramuscularly may be a useful non-steroid anti-inflammatory drug in nursehound sharks. Further pharmacodynamic studies are needed to fully evaluate its clinical use in this species.
Fungal Diseases in Elasmobranchs and Their Possible Treatment with a Special Mention to Azole Antifungal Agents
(Animals, 2023) Cañizares Cooz, Daniela; García Párraga, Daniel; Plá González, Emma; Rojo Solís, Carlos; Encinas Cerezo, María Teresa; Morón Elorza, Pablo
Introduction: Elasmobranchs currently constitute an important part of the animal collection of many aquariums worldwide. Their maintenance under human care has allowed us to describe and identify new pathogens and diseases affecting them, as well as to determine different treatments for these diseases. Great advances in elasmobranch husbandry have been developed. Methods: A search was performed on scientific databases as PubMed and other specialized sources (IAAAM archive). Results: Little information on pharmacotherapeutics is available in this taxonomic group, and treatments lack a scientific base and instead are frequently dependent on empirical knowledge. Pharmacokinetic studies are the first step to determining therapeutic protocols that are safe and effective. The available bibliography shows that a majority of the mycoses recorded in cartilaginous fish are severe, aggravated by the fact that the antifungal treatments administered, following the guidelines used for teleost species, are ineffective in elasmobranchs. Azoles appear to be a promising group of antifungals for use in treating systemic mycoses in sharks and rays. Conclusions: Based on the findings of this review, it is essential to investigate the pharmacokinetics of the different antifungals in these species in order to provide therapeutic options for fungal infections in cartilaginous fish.