Person: Moyano-Cires Ivanoff, Paula Viviana
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First Name
Paula Viviana
Last Name
Moyano-Cires Ivanoff
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Veterinaria
Department
FarmacologÃa y ToxicologÃa
Area
ToxicologÃa
Identifiers
14 results
Search Results
Now showing 1 - 10 of 14
Publication GuÃa de prácticas y seminarios de Fundamentos de ToxicologÃa(2021) Ramos Alonso, Eva; Del Pino Sans, Javier; Romero MartÃnez, Manuel Alejandro; DÃaz Plaza, MarÃa Jesús; Frejo Moya, MarÃa Teresa; Moyano-Cires Ivanoff, Paula VivianaPublication Aprendizaje global, flexible y personalizado para atender la diversidad en el aula, mediante el uso de Flipped Learning, a través del uso integrado de un sistema virtual de respuesta en el aula, y otras herramientas TACs digitales(2021-06) Del Pino Sans, Javier; Moyano-Cires Ivanoff, Paula Viviana; Frejo Moya, MarÃa Teresa; Anadón Baselga, MarÃa José; Lobo Alonso, Margarita; Pelayo Alarcon, Adela; Capo Marti, Miguel Andrés; Sola Vendrell, Emma; Sanjuán López, Javier; GarcÃa Sánchez, José Manuel; Ruiz Fernandez, Matilde; Mourin Moral, Francisco Javier; Frias González, Mariano De; Naval López, MarÃa Victoria; Guerra Menéndez, Lucia; Garcia Lobo, JimenaPublication Neuroprotective mechanisms of multitarget 7-aminophenanthridin-6(5H)-one derivatives against metal-induced amyloid proteins generation and aggregation(Elsevier, 2022-07-02) Moyano-Cires Ivanoff, Paula Viviana; Vicente Zurdo, David; Blázquez Barbadillo, Cristina; Menéndez, J. Carlos; González Matilla, Juan Francisco; Rosales Conrado, Noelia; Pino Sans, Javier delBrain’s metals accumulation is associated with toxic proteins, like amyloid-proteins (Aβ), formation, accumulation, and aggregation, leading to neurodegeneration. Metals downregulate the correct folding, disaggregation, or degradation mechanisms of toxic proteins, as heat shock proteins (HSPs) and proteasome. The 7-amino-phenanthridin-6(5H)-one derivatives (APH) showed neuroprotective effects against metal-induced cell death through their antioxidant effect, independently of their chelating activity. However, additional neuroprotective mechanisms seem to be involved. We tested the most promising APH compounds (APH1-5, 10–100 μM) chemical ability to prevent metal-induced Aβ proteins aggregation; the APH1-5 effect on HSP70 and proteasome 20S (P20S) expression, the metals effect on Aβ formation and the involvement of HSP70 and P20S in the process, and the APH1-5 neuroprotective effects against Aβ proteins (1 μM) and metals in SN56 cells. Our results show that APH1-5 compounds chemically avoid metal-induced Aβ proteins aggregation and induce HSP70 and P20S expression. Additionally, iron and cadmium induced Aβ proteins formation through downregulation of HSP70 and P20S. Finally, APH1-5 compounds protected against Aβ proteins-induced neuronal cell death, reversing partially or completely this effect. These data may help to provide a new therapeutic approach against the neurotoxic effect induced by metals and other environmental pollutants, especially when mediated by toxic proteins.Publication Aprendizaje colaborativo/competitivo mediante gamificación, a través del uso integrado de un mando wiimote como pizarra digital interactiva, un sistema virtual de respuesta en el aula, y dispositivos móviles con acceso a internet(2017-06-21) Del Pino Sans, Javier; Anadon Baselga, MarÃa Jose; Frejo Moya, MarÃa Teresa; Diaz Plaza, MarÃa Jesús; Capó MartÃ, Miguel Andrés; GarcÃa Lobo, Jimena; Lobo Alonso, Margarita; Moyano-Cires Ivanoff, Paula Viviana; Zeballos Deza, Gabriela; Flores Calle, AndreaIntegración de pizarra digital, una aplicación informática propia como sistema de respuesta (clicker) y otras aplicaciones no propias para facilitar la evaluación continua, aumentar la motivación y rendimiento de los estudiantes a un coste muy bajo.Publication GuÃa de Prácticas de Laboratorio y seminarios de ToxicologÃa Veterinaria(2021) Ramos Alonso, Eva; Del Pino Sans, Javier; Romero MartÃnez, Manuel Alejandro; DÃaz Plaza, MarÃa Jesús; Frejo Moya, MarÃa Teresa; Moyano-Cires Ivanoff, Paula VivianaPublication Aprendizaje flexible y personalizado para atender la diversidad en el aula, mediante el uso del flipped learning (aprendizaje invertido), a través del uso integrado de un sistema virtual de respuesta en el aula, y otras herramientas TACs(2020-06-17) Del Pino Sans, Javier; Moyano-Cires Ivanoff, Paula Viviana; Frejo Moya, MarÃa Teresa; Lobo Alonso, Margarita; GarcÃa Lobo, Jimena; Anadón Baselga, MarÃa José; Capo Marti, Miguel Andrés; Frias González, Mariano De; Rojas López, Francisco Javier; Ruiz Fernández, Matilde; Sola Vendrell, Emma; Mourin Moral, Francisco Javier; Sanjuán López, Javier; GarcÃa Sánchez, José ManuelIntegración de una aplicación informática propia como sistema de respuesta (clicker) y diferentes herramientas TCs para facilitar la evaluación continua de forma personalizada, aumentar la motivación y rendimiento de los estudiantes a bajo coste.Publication GuÃa de Prácticas de Laboratorio y seminarios de ToxicologÃa de los Alimentos(2021) Moyano-Cires Ivanoff, Paula Viviana; Del Pino Sans, Javier; Romero MartÃnez, Manuel Alejandro; DÃaz Plaza, MarÃa Jesús; Frejo Moya, MarÃa Teresa; Ramos Alonso, EvaPublication Neuroprotective Action of Multitarget 7-Aminophenanthridin-6(5H)-one Derivatives against Metal-Induced Cell Death and Oxidative Stress in SN56 Cells(ACS Publications, 2021-08-30) Moyano-Cires Ivanoff, Paula Viviana; Vicente Zurdo, David; Blázquez-Barbadillo, Cristina; Menéndez Ramos, José Carlos; González Matilla, Juan Francisco; Rosales Conrado, Noelia; Pino Sans, Javier delNeurodegenerative diseases have been associated with brain metal accumulation, which produces oxidative stress (OS), matrix metalloproteinases (MMPs) induction, and neuronal cell death. Several metals have been reported to downregulate both the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway and the antioxidant enzymes regulated by it, mediating OS induction and neurodegeneration. Among a recently discovered family of multitarget 7-amino-phenanthridin-6-one derivatives (APH) the most promising compounds were tested against metal-induced cell death and OS in SN56 cells. These compounds, designed to have chelating activity, are known to inhibit some MMPs and to present antioxidant and neuroprotective effects against hydrogen peroxide treatment to SN56 neuronal cells. However, the mechanisms that mediate this protective effect are not fully understood. The obtained results show that compounds APH1, APH2, APH3, APH4, and APH5 were only able to chelate iron and copper ions among all metals studied and that APH3, APH4, and APH5 were also able to chelate mercury ion. However, none of them was able to chelate zinc, cadmium, and aluminum, thus exhibiting selective chelating activity that can be partly responsible for their neuroprotective action. Otherwise, our results indicate that their antioxidant effect is mediated through induction of the Nrf2 pathway that leads to overexpression of antioxidant enzymes. Finally, these compounds exhibited neuroprotective effects, reversing partially or completely the cytotoxic effects induced by the metals studied depending on the compound used. APH4 was the most effective and safe compound.Publication Insulin Signaling Disruption and INF-γ Upregulation Induce Aβ1–42 and Hyperphosphorylated-Tau Proteins Synthesis and Cell Death after Paraquat Treatment of Primary Hippocampal Cells(ACS Publications, 2022-11-17) Abascal, Maria Luisa; Sanjuan, Javier; Moyano-Cires Ivanoff, Paula Viviana; Sola Vendrell, Emma; Flores, Andrea; GarcÃa Sánchez, José Manuel; GarcÃa Lobo, Jimena; Frejo Moya, MarÃa Teresa; Pino Sans, Javier delAcute and long-term paraquat (PQ) exposure produces hippocampal neurodegeneration and cognition decline. Although some mechanisms involved in these effects were found, the rest are unknown. PQ treatment, for 1 and 14 days, upregulated interferon-gamma signaling, which reduced insulin levels and downregulated the insulin pathway through phosphorylated-c-Jun N-terminal-kinase upregulation, increasing glucose levels and the production of Aβ1–42 and phosphorylated-tau, by beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) overexpression and phosphorylated-GSK3β (p-GSK3β; ser9) level reduction, respectively, which induced primary hippocampal neuronal loss. This novel information on the PQ mechanisms leading to hippocampal neurodegeneration could help reveal the PQ actions that lead to cognition dysfunction.Publication Efectos neurotóxicos del clorpirifos sobre el sistema colinérgico e implicaciones legales del uso del perfil toxicogenómico como biomarcador de toxicidad(Universidad Complutense de Madrid, 2017-09-08) Moyano-Cires Ivanoff, Paula Viviana; Pino Sans, Javier del; Anadón Baselga, MarÃa José; Capó MartÃ, Miguel AndrésClorpirifós (CPF) es uno de los insecticidas organofosforados (OP) más utilizados en aplicaciones agrÃcolas y residenciales (Figura 1). El CPF es capaz de causar alteraciones de desarrollo, inmunológicas, y efectos neurotóxicos. Por otra parte, la exposición ocupacional a los OP se ha relacionado, en estudios epidemiológicos en humanos, con déficits neurológicos y neuroconductuales, incluyendo alteraciones de la cognición. En este sentido, el CPF se ha demostrado que produce en ratas tras la administración aguda y repetida, déficits de aprendizaje similares a los inducidos en la enfermedad de Alzheimer (AD). Sin embargo, los mecanismos completos a través del cual el CPF induce estas alteraciones cognitivas son desconocidos...