Person:
Martínez Hernández, David

First Name

David

Last Name

Martínez Hernández

URI

https://hdl.handle.net/20.500.14352/79350

Affiliation

Universidad Complutense de Madrid

Faculty / Institute

Medicina

Department

Salud Pública y Materno-Infantil

Area

Medicina Preventiva y Salud Pública

Identifiers

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Search Results

Now showing 1 - 10 of 10

Trends in Incidence and Outcomes of Hospitalizations for Urinary Tract Infection among Older People in Spain (2001–2018)
(Journal of Clinical Medicine, 2021) Palacios Ceña, Domingo; Florencio, Lidiane Lima; Hernández Barrera, Valentín; Fernández de las Peñas, César; Miguel Díez, Javier de; Martínez Hernández, David; Carabantes Alarcón, David; Jiménez García, Rodrigo; López de Andrés, Ana; López Herranz, Marta
(1) Background: To assess time trends in the incidence and in-hospital outcomes of urinary tract infection (UTI) in older people (≥65 years) in Spain (2001–2018) according to sex and to identify the factors independently associated with in-hospital mortality (IHM). (2) Methods: Using the Spanish National Hospital Database, we analyzed comorbidity, procedures, diagnosis, isolated microorganisms, and outcomes. (3) Results: We included 583,693 admissions (56.76% women). In both sexes, the incidence increased with age over time (p < 0.001). In men and women, the highest IHM was found among the oldest patients (>84 years) with values of 9.16% and 8.6%, respectively. The prevalence of bacteremia increased from 4.61% to 4.98% from 2001 to 2018 (p < 0.001) and sepsis decreased from 3.16% to 1.69% (p < 0.001). The risk of dying increased with age (>84 years) (OR 3.63; 95% CI 3.5–3.78) and with almost all comorbidities. Urinary catheter was a risk factor for women (OR 1.1; 95% CI 1.02–1.18) and protective for men (OR 0.71; 95% CI 0.66–0.76). Isolation of Staphylococcus aureus increased the risk of IHM by 40% among men (OR 1.4; 95% CI 1.28–1.53). After adjusting for confounders, IHM decreased over time. (4) Conclusions: The incidence of UTIs was higher in older patients and increased over time; however, IHM decreased during the same period. Female sex, age, comorbidities, sepsis, and a Staphylococcus aureus isolation increased risk of IHM.
The role of prenatal exposure to antidepressants, anxiolytic, and hypnotics and its underlying illness on the risk of miscarriage using BIFAP database
(Pharmacoepidemiology and Drug Safety, 2022) Kitchin, Álvaro; Huerta Álvarez, Consuelo; Llorente García, Ana; Martínez Hernández, David; Ortega Molina, Paloma; Cea Soriano, Lucía
Purpose: Despite the notable increase on the prescription of antidepressants and anxiolytics during pregnancy, recommendation on maintaining the treatment during prenatal period is still controversial. We aimed to separately assess the role of effects of the antidepressants and anxiolytic and the underlying illness, controlled by potential confounding associated with miscarriage onset. Methods: We used data from a validated pregnant cohort aged 15–49 years from 2002 to 2016 using BIFAP database. All confirmed miscarriages were used to perform a nested control analysis using conditional logistic regression. Women were classified according to use of each drug of interest into four mutually exclusive groups: nonusers, users only during prepregnancy, continuers, and initiators during first trimester. Adjusted odds ratios (aORs) for major confounders during pregnancy such as number of visits to primary care practitioners visits, obesity, smoking, HTA, diabetes with 95% confidence intervals were calculated. Results: Compared with nonusers, antidepressants continuers had the highest increased risk of miscarriage aOR (95%) of 1.29 (1.13–1.46), being continuers of paroxetine and fluoxetine the antidepressants with the strongest association. Likewise, continuers of anxiolytics and initiators showed an increased risk of 1.19 (1.04–1.37) and 1.30 (1.13–1.50). When separating the effect between the condition itself or the treatment, women exposed during first trimester, regardless treatment duration and/or the underlying illness, had the highest risk 1.27 (1.08–1.51) for antidepressants and 1.25 (1.13–1.39) for anxiolytics. Conclusions: Our analysis showed an association between prenatal exposure to antidepressants and anxiolytics and miscarriage onset after controlling by potential confounding adjusting for confounders and the underlying illness. This association was not supported for hypnotic medications. Further studies are warranted to evaluate the risk of miscarriage among subpopulation of pregnant women requiring these medications.
Project number: 102
Innovación en la enseñanza virtual de la Medicina Preventiva y Salud Pública en el ámbito clínico
(2021) Albaladejo Vicente, Romana; Calle Purón, María Elisa; Elvira Martínez, Carlos María; Jiménez García, Rodrigo; Martínez Hernández, David; Miguel Díez, Javier de; Villanueva Orbáiz, María Rosa Rita; Zamorano León, José Javier; López de Andrés, Ana; Gutiérrez Albaladejo, Natalia; Herrera Marcos, Isabel; Hernandez Jiménez,, José Antonio
Project number: 174
Epidemiología básica. Material docente para prácticas en ciencias de la salud
(2018) Pérez Farinós, José Napoleón; Wärnberg, Julia; Santos Sancho, Juana Mª; Ajejas Bazán, Mª Julia; López de Andrés, Ana; Pérez López, Jéssica; Benavente Marín, Juan Carlos; Romero Galisteo, Rita Pilar; Cueto Galán, Raquel; Albaladejo Vicente, Romana; Villanueva Orbáiz, Mª Rosa Rita; Astasio Arbiza, Paloma; Barón López, Javier; Jiménez García, Rodrigo; Jiménez Trujillo, María Isabel; Sordo del Castillo, Luis; Cea Soriano, Trinidad Lucía; Morales Cerchiaro, Ángela Patricia; Sanz Rojo, Sara; Hernández Barrera, Valentín; Martínez Hernández, David; Ortega Molina, Paloma; Calle Purón, Mª Elisa; Hedo Prieto, Mª Teresa
Material docente teórico práctico para apoyar la enseñanza de la epidemiología. Consta de 4 unidades, cada una de ellas con una introducción teórica y unos ejercicios basados en artículos publicados en inglés en revistas científicas.
Is There an Association between Diabetes and Neck and Back Pain? Results of a Case-Control Study
(Journal of Clinical Medicine, 2020) Lima Florencio, Lidiane; López De Andrés, Ana Isabel; Hernández Barrera, Valentín; Palacios Ceña, Domingo; Fernández de las Peñas, César; Jiménez García, Rodrigo; Pérez Farinós, José Napoleón; Carabantes Alarcón, David; Martínez Hernández, David; Albaladejo Vicente, Romana
We aimed to assess if subjects with diabetes exhibit higher prevalence of chronic back pain than age-sex-province of residence-matched non-diabetic controls. We also aimed to identify predictors for chronic neck pain (CNP) or chronic low back pain (CLBP) among subjects with diabetes. A case control study was conducted using data obtained from the Spanish National Health Survey 2017. Multivariable conditional and unconditional logistic regression models were constructed. A total of 2095 diabetes sufferers and 2095 non-diabetic matched controls were analyzed. The prevalence of CNP and CLBP was 27.3% and 34.8%, respectively, in diabetes sufferers and 22.1% and 29.0% in non-diabetes controls (both, p < 0.001). After multivariable analysis, the ORs showed significantly higher adjusted risk of CNP (OR 1.34; 95% CI 1.19-1.51) and CLBP (OR 1.19, 95% CI 1.09-1.31) in diabetes cases. Diabetes sufferers with CNP or CLBP showed higher use of pain medication and higher prevalence of migraine/frequent headache than controls. Female sex, worse self-rated health and use of pain medication were predictors for CNP and CLBP in subjects with diabetes. CNP and CLBP are significantly more prevalent in diabetes sufferers than in controls. Current results can help to design better preventive and educational strategies for these highly prevalent and burdensome pains among diabetic patients.
Project number: 218
Medición de la efectividad de las presentaciones en las clases magistrales y en las exposiciones de trabajos avanzados de estudiantes
(2023) Villanueva Orbáiz, Rosa; Albaladejo Vicente, Romana; Bodas Pinedo, Andrés; Carabantes Alarcón, David; Jiménez Sierra, Lucía; López Herrero, María Jesús; López Martín, Beatriz; Martínez Hernández, David; Prego Meleiro, Pablo
Valoración de las presentaciones realizadas con funciones avanzadas de PowerPoint, tanto por los profesores para impartir sus clases en los estudios de Grado y Máster, como por los estudiantes con trabajos de asignaturas como exposiciones previas a sus Trabajos Fin de Máster (TFM) y Tesis Doctorales
Project number: 71
La aplicabilidad de los conocimientos y competencias adquiridos en el aula desde la perspectiva laboral como herramienta docente en salud pública
(2019) Ortega Molina, Paloma; Cea Soriano, Trinidad Lucía; Astasio Arbiza, Paloma; Santos Sancho, Juana María; Martínez Hernández, David; Sánchez Ortiz, Sara; Hedo Prieto, María Teresa
Project number: 139
Evaluación del profesorado de Medicina en Práctica Clínica
(2016) Álvarez-Sala Walther, Jose Luis; Álvarez-Sala Walther, Luis Antonio; Calvo Manuel, Elpidio; Fernández Galaz, Carmen; García Seoane, Jorge; López Gallardo, Meritxell; Cuadrado Pérez, María Luz; Martínez Hernández, David; Millán Núñez Cortés, Jesús; Ortega Molina, Paloma; Pérez de Oteiza, Carlos Antonio; Tejedor Jorge, Alberto; Villena Garrido, María Victoria
Project number: 206
Idoneidad y validez de herramientas que fomentan el aprendizaje asociativo a partir de exámenes tipo test
(2020) Cea Soriano, Trinidad Lucia; Garcia seoane, Jorge Juan; Ortega Molina, Paloma; López Gallardo, Meritxell; Astasio Arbiza, Paloma; Martínez Hernández, David; Lázaro Fernández, Alberto; Santos Sancho, Juana María; García Ferrera, Alicia; Gutiérrez Albaladejo, Natalia; Herrera Marcos, Isabel
Impacto del consumo de antibióticos de uso tópico oftalmológico
(Revista Española de Quimioterapia, 2010) García, Sofía; Mori Vara, Pilar; López, Ana; Alou Cervera, Luis; Martínez Hernández, David; Ramos, Carmen; Gómez-Lus Centelles, María Luisa
Introducción. El objetivo del estudio fue conocer el impacto del consumo de los antibióticos de uso tópico utilizados en oftalmología y sentar las bases para su uso prudente. Material y métodos. Se realizó un estudio cuantitativo descriptivo sobre el consumo de medicamentos entre 1 de enero de 2004 y el 31 de diciembre de 2008. Los medicamentos utilizados para la realización de este estudio, debían cumplir los siguientes criterios: vía de administración tópica y antimicrobianos oftalmológicos sólo o en asociación. Los datos que hacen referencia al número de envases fueron cedidos por Intercontinental Marketing Services (IMS) y los datos de consumo hospitalario se obtuvieron de Sistema Nacional de Salud. Se estudiaron aquellas variables que hacen referencia estrictamente al consumo. Resultados. El mercado de antiinfecciosos oftalmológicos hospitalario y extrahospitalario en 2008 supuso 4,9 y 24,4 millones de euros, respectivamente incrementándose un 5.5% respecto al año anterior. Se consumieron más de 6 millones de envases de los que el 65% se utilizó en preparados monoantibióticos frente al 35% en asociación. Los antibióticos oftálmicos en monoterapia más consumidos fueron los aminoglucósidos (tobramicina y gentamicina) seguido de las quinolonas mientras que en asociación el más consumido fue gramicidina + neomicina + polimixina B. Conclusiones. El mercado de antiinfecciosos oftalmológicos, solos y combinados, utilizados tanto en el medio extrahospitalario como hospitalario, representa casi 30 millones de euros y muestra un crecimiento en torno al 6%. Las rígidas medidas sobre el consumo de antibióticos en general no son tenidas en cuenta en el campo de los antibióticos tópicos oftálmicos.