Person:
Martínez Hernández, David

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First Name
David
Last Name
Martínez Hernández
URI
https://hdl.handle.net/20.500.14352/79350
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Medicina
Department
Salud Pública y Materno-Infantil
Area
Medicina Preventiva y Salud Pública
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2016 - 201932020 - 20222
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Author: Ortega Molina, Paloma × Has files: true ×

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Now showing 1 - 5 of 5
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    The role of prenatal exposure to antidepressants, anxiolytic, and hypnotics and its underlying illness on the risk of miscarriage using BIFAP database
    (Pharmacoepidemiology and Drug Safety, 2022) Kitchin, Álvaro; Huerta Álvarez, Consuelo; Llorente García, Ana; Martínez Hernández, David; Ortega Molina, Paloma; Cea Soriano, Lucía
    Purpose: Despite the notable increase on the prescription of antidepressants and anxiolytics during pregnancy, recommendation on maintaining the treatment during prenatal period is still controversial. We aimed to separately assess the role of effects of the antidepressants and anxiolytic and the underlying illness, controlled by potential confounding associated with miscarriage onset. Methods: We used data from a validated pregnant cohort aged 15–49 years from 2002 to 2016 using BIFAP database. All confirmed miscarriages were used to perform a nested control analysis using conditional logistic regression. Women were classified according to use of each drug of interest into four mutually exclusive groups: nonusers, users only during prepregnancy, continuers, and initiators during first trimester. Adjusted odds ratios (aORs) for major confounders during pregnancy such as number of visits to primary care practitioners visits, obesity, smoking, HTA, diabetes with 95% confidence intervals were calculated. Results: Compared with nonusers, antidepressants continuers had the highest increased risk of miscarriage aOR (95%) of 1.29 (1.13–1.46), being continuers of paroxetine and fluoxetine the antidepressants with the strongest association. Likewise, continuers of anxiolytics and initiators showed an increased risk of 1.19 (1.04–1.37) and 1.30 (1.13–1.50). When separating the effect between the condition itself or the treatment, women exposed during first trimester, regardless treatment duration and/or the underlying illness, had the highest risk 1.27 (1.08–1.51) for antidepressants and 1.25 (1.13–1.39) for anxiolytics. Conclusions: Our analysis showed an association between prenatal exposure to antidepressants and anxiolytics and miscarriage onset after controlling by potential confounding adjusting for confounders and the underlying illness. This association was not supported for hypnotic medications. Further studies are warranted to evaluate the risk of miscarriage among subpopulation of pregnant women requiring these medications.
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    Project number: 174
    Epidemiología básica. Material docente para prácticas en ciencias de la salud
    (2018) Pérez Farinós, José Napoleón; Wärnberg, Julia; Santos Sancho, Juana Mª; Ajejas Bazán, Mª Julia; López de Andrés, Ana; Pérez López, Jéssica; Benavente Marín, Juan Carlos; Romero Galisteo, Rita Pilar; Cueto Galán, Raquel; Albaladejo Vicente, Romana; Villanueva Orbáiz, Mª Rosa Rita; Astasio Arbiza, Paloma; Barón López, Javier; Jiménez García, Rodrigo; Jiménez Trujillo, María Isabel; Sordo del Castillo, Luis; Cea Soriano, Trinidad Lucía; Morales Cerchiaro, Ángela Patricia; Sanz Rojo, Sara; Hernández Barrera, Valentín; Martínez Hernández, David; Ortega Molina, Paloma; Calle Purón, Mª Elisa; Hedo Prieto, Mª Teresa
    Material docente teórico práctico para apoyar la enseñanza de la epidemiología. Consta de 4 unidades, cada una de ellas con una introducción teórica y unos ejercicios basados en artículos publicados en inglés en revistas científicas.
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    Project number: 71
    La aplicabilidad de los conocimientos y competencias adquiridos en el aula desde la perspectiva laboral como herramienta docente en salud pública
    (2019) Ortega Molina, Paloma; Cea Soriano, Trinidad Lucía; Astasio Arbiza, Paloma; Santos Sancho, Juana María; Martínez Hernández, David; Sánchez Ortiz, Sara; Hedo Prieto, María Teresa
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    Project number: 139
    Evaluación del profesorado de Medicina en Práctica Clínica
    (2016) Álvarez-Sala Walther, Jose Luis; Álvarez-Sala Walther, Luis Antonio; Calvo Manuel, Elpidio; Fernández Galaz, Carmen; García Seoane, Jorge; López Gallardo, Meritxell; Cuadrado Pérez, María Luz; Martínez Hernández, David; Millán Núñez Cortés, Jesús; Ortega Molina, Paloma; Pérez de Oteiza, Carlos Antonio; Tejedor Jorge, Alberto; Villena Garrido, María Victoria
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    Project number: 206
    Idoneidad y validez de herramientas que fomentan el aprendizaje asociativo a partir de exámenes tipo test
    (2020) Cea Soriano, Trinidad Lucia; Garcia seoane, Jorge Juan; Ortega Molina, Paloma; López Gallardo, Meritxell; Astasio Arbiza, Paloma; Martínez Hernández, David; Lázaro Fernández, Alberto; Santos Sancho, Juana María; García Ferrera, Alicia; Gutiérrez Albaladejo, Natalia; Herrera Marcos, Isabel