Person:
Fernández Gutiérrez, Benjamín

Profile Picture
First Name
Benjamín
Last Name
Fernández Gutiérrez
URI
https://hdl.handle.net/20.500.14352/79576
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Medicina
Department
Medicina
Area
Medicina
Identifiers
UCM identifierORCIDScopus Author IDWeb of Science ResearcherIDDialnet ID

Filters

20212
Reset filters

Settings

Author: Fernández Gutiérrez, Benjamín × Item Type: Publication ×

Search Results

Now showing 1 - 2 of 2
  • Thumbnail Image
    Item
    Influence of Mesenchymal Stem Cell Sources on Their Regenerative Capacities on Different Surfaces
    (Cells, 2021) Mucientes, Arkaitz; Herranz, Eva; Moro Rodríguez, Luis Enrique; González Corchón, Aranzazu; Peña-Soria, María Jesús; Abásolo Alcázar, Lydia; Rodriguez Rodriguez, Luis; Lamas, Jose Ramon; Fernández Gutiérrez, Benjamín
    Current gold-standard strategies for bone regeneration do not achieve the optimal recovery of bone biomechanical properties. To bypass these limitations, tissue engineering techniques based on hybrid materials made up of osteoprogenitor cells—such as mesenchymal stem cells (MSCs)—and bioactive ceramic scaffolds—such as calcium phosphate-based (CaPs) bioceramics—seem promising. The biological properties of MSCs are influenced by the tissue source. This study aims to define the optimal MSC source and construct (i.e., the MSC–CaP combination) for clinical application in bone regeneration. A previous iTRAQ analysis generated the hypothesis that anatomical proximity to bone has a direct effect on MSC phenotype. MSCs were isolated from adipose tissue, bone marrow, and dental pulp, then cultured both on a plastic surface and on CaPs (hydroxyapatite and β-tricalcium phosphate), to compare their biological features. On plastic, MSCs isolated from dental pulp (DPSCs) presented the highest proliferation capacity and the greatest osteogenic potential. On both CaPs, DPSCs demonstrated the greatest capacity to colonise the bioceramics. Furthermore, the results demonstrated a trend that DPSCs had the most robust increase in ALP activity. Regarding CaPs, β-tricalcium phosphate obtained the best viability results, while hydroxyapatite had the highest ALP activity values. Therefore, we propose DPSCs as suitable MSCs for cell-based bone regeneration strategies.
  • Thumbnail Image
    Item
    Project number: 240
    Aprendizaje activo basado en la resolución de casos clínico-radiológicos de patología del aparato locomotor en enseñanza virtual
    (2021) Crespo Rodríguez, Ana María; Archanco Olcese, Miguel; Cabrera Martín, Mª Nieves; Carreras Delgado, José Luis; Casado Herráez, Antonio; Corona Sánchez, Juan Antonio; Cuenca González, Concepción; Fernández Gutiérrez, Benjamín; Francés Borrego, Alberto; García Merino, Mikel; Gómez Peña, Sara; Lópiz Morales, María Yaiza; Marco Martínez, Fernando; Marquina Ospina, Gloria; Muñoz Hernando, Miriam; Nava Muñoz, Ángel
    Las estrategias de enseñanza on-line basadas en Tecnologías de la Información y la Comunicación (TIC) se han utilizado con éxito para acercar la práctica clínica de Radiología a los estudiantes de Grado de Medicina durante el curso académico 2020-21. Los alumnos trabajaron por equipos con el método de Aprendizaje Basado en la Resolución de Problemas (ABRP). De esta manera, se aseguró la consecución de los objetivos formativos y se dio a conocer la forma de trabajo del médico radiólogo, el proceso de razonamiento diagnóstico, los sistemas de información de los hospitales y en particular del Picture Archiving and Communication System (PACS).