Person:
Vidal Lloret, Perfecto

Profile Picture
First Name
Perfecto
Last Name
Vidal Lloret
URI
https://hdl.handle.net/20.500.14352/86907
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Ciencias Matemáticas
Department
Análisis Matemático Matemática Aplicada
Area
Análisis Matemático
Identifiers
UCM identifierScopus Author IDDialnet ID

Filters

20181
Reset filters

Settings

Author: Birnir, Bjorn × Item Type: Publication ×

Search Results

Now showing 1 - 1 of 1
  • Thumbnail Image
    Item
    Dynamic energy budget approach to evaluate antibiotic effects on biofilms
    (Communications in Nonlinear Science and Numerical Simulation, 2018) Birnir, Bjorn; Carpio Rodríguez, Ana María; Cebrián, Elena; Vidal Lloret, Perfecto
    Quantifying the action of antibiotics on biofilms is essential to devise therapies against chronic infections. Biofilms are bacterial communities attached to moist surfaces, sheltered from external aggressions by a polymeric matrix. Coupling a dynamic energy budget based description of cell metabolism to surrounding concentration fields, we are able to approximate survival curves measured for different antibiotics. We reproduce numerically stratified distributions of cell types within the biofilm and introduce ways to incorporate different resistance mechanisms. Qualitative predictions follow that are in agreement with experimental observations, such as higher survival rates of cells close to the substratum when employing antibiotics targeting active cells or enhanced polymer production when antibiotics are administered. The current computational model enables validation and hypothesis testing when developing therapies.