Person:
López Cabarcos, Enrique

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First Name
Enrique
Last Name
López Cabarcos
URI
https://hdl.handle.net/20.500.14352/77519
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Farmacia
Department
Química en Ciencias Farmacéuticas
Area
Química Física
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    Enhancement of the Upconversion Emission by Visible-to-Near-Infrared Fluorescent Graphene Quantum Dots for miRNA Detection
    (ACS Applied Materials & Interfaces, 2016) Laurenti, Marco; Paez-Pérez, Miguel; Algarra González, Manuel; Alonso Cristobal, Paulino; López Cabarcos, Enrique; Méndez González, Diego; Rubio Retama, Benito Jorge
    We developed a sensor for the detection of specific microRNA (miRNA) sequences that was based on graphene quantum dots (GQDs) and ssDNA-UCNP@SiO2. The proposed sensor exploits the interaction between the sp2 carbon atoms of the GQD, mainly π–π stacking, and the DNA nucleobases anchored on the upconversion nanoparticles (UCNPs). This interaction brings the GQD to the surface of the ssDNA-UCNP@SiO2 system, enhancing the upconversion emission. On the other hand, hybridization of the single-stranded DNA (ssDNA) chains anchored on the nanoparticles with their complementary miRNA sequences blocks the capacity of the UCNPs to interact with the GQD through π–π stacking. That gives as result a reduction of the fluorescent enhancement, which is dependent on the concentration of miRNA sequences. This effect was used to create a sensor for miRNA sequences with a detection limit of 10 fM.
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    Multi-responsive hybrid Janus nanoparticles: Surface functionalization through solvent physisorption
    (European Polymer Journal, 2016) Méndez González, Diego; Alonso-Cristobal, Paulino; López Cabarcos, Enrique; Rubio Retama, Benito Jorge
    In this work, we present a simple methodology to produce multi-responsive Janus nanoparticles using a Pickering emulsion-based approach. In order to use these nanoparticles (NPs) as emulsion stabilizers, tetrahydrofuran was physisorbed on the surface of freshly synthesized Fe3O4@SiO2 NPs, which reduced their inherent hydrophilic character and permitted to create a close packed arrangement of particles at the emulsion interface. This situation allowed selective functionalization of the surface of the nanoparticles exposed to the water phase with a vinyl derivate molecule, which permitted to initiate the sequential polymerization of pNIPAM and poly(vinylimidazole). Thus, we obtained Janus nanoparticles that responded to changes in the temperature and the pH of the media as well as to external magnetic fields. The presented method does not require the surface modification of the original nanoparticles with surfactants or the use of fused silica and provides an easy way to create Janus particles in the nanoscale range.