Person:
Sánchez Montero, José

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First Name
José
Last Name
Sánchez Montero
URI
https://hdl.handle.net/20.500.14352/77626
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Farmacia
Department
Química en Ciencias Farmacéuticas
Area
Química Orgánica
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2014 - 20197
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End date: 2019 ×

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Now showing 1 - 7 of 7
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    Mesoporous silica nanoparticles as a new carrier methodology in the controlled release of the active components in a polypill
    (European Journal of Pharmaceutical Sciences, 2017) Doadrio Villarejo, Antonio Luis; Sánchez Montero, José; Doadrio Villarejo, Juan Carlos; Salinas Sánchez, Antonio Jesús; Vallet Regí, María Dulce Nombre
    Polypill is a medication designed for preventing heart attacks through a combination of drugs. Current formulations contain blood pressure-lowering drugs and others, such statins or acetylsalicylic acid. These drugs exhibit different physical chemical features, and consequently different release kinetics. Therefore, the concentration in plasma of some of them after the release process can be out of the therapeutic range. This paper investigates a new methodology for the control dosage of a polypill recently reported containing hydrochlorothiazide, amlodipine, losartan and simvastatin in a 12.5/2.5/25/40 weight ratio. The procedure is based onmesoporous silica nanoparticles (MSN) with MCM-41 structure (MSN-41) used as carrier, aimed to control release of the four drugs included in the polypill. In vitro release data were obtained by HPLC and the curves adjusted with a kinetic model. To explain the release results, a molecular model was built to determine the drug-matrix interactions, and quantum mechanical calculations were performed to obtain the electrostatic properties of each drug. Amlodipine, losartan and simvastatin were released from the polypill-MSN-41 system in a controlled way. This would be a favourable behavior when used clinically because avoid too quick pressure decrease. However, the diuretic hydrochlorothiazide was quickly released from our system in the first minutes, as is needed in hypertensive urgencies. In addition, an increase in the stability of amlodipine and hydrochlorothiazide occurred in the polypill-MSN-41 system. Therefore, the new way of polypill dosage proposed can result in a safer and effective treatment. (C) 2016 Elsevier B.V. All rights reserved.
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    Docking studies for melatonin receptors
    (Expert Opinion on Drug Discovery, 2018) Awad Alkozia, Hanan; Sánchez Montero, José; Doadrio Villarejo, Antonio Luis; Pintor Just, Jesús Jerónimo; Pintor Just, Jesús Jerónimo
    La melatonina es una neurohormona que controla muchos procesos fisiológicos relevantes más allá del control de los ritmos circadianos. Las acciones de la melatonina son llevadas a cabo por dos tipos principales de receptores de melatonina: MT1 y MT2. Estos receptores son importantes, no solo debido a las acciones biológicas de su agonista natural, sino también porque los análogos de melatonina pueden mejorar o antagonizar su efecto biológico. El siguiente artículo describe la importancia de la melatonina como una molécula biológicamente relevante. También define los receptores para esta sustancia, así como los segundos mensajeros acoplados a estos receptores. Por último, el artículo describe los residuos de aminoácidos involucrados en el proceso de acoplamiento en los receptores de melatonina MT1 y MT2. Las acciones biológicas de la melatonina y sus interpretaciones están volviéndose más relevantes y, por lo tanto, requieren el desarrollo de nuevas herramientas farmacológicas. Comprender los mecanismos de los segundos mensajeros involucrados en las acciones de la melatonina, así como las características del acoplamiento de esta molécula a los receptores de melatonina MT1 y MT2, permitirá el desarrollo de agonistas y antagonistas más selectivos que nos ayudarán a comprender mejor esta molécula y a desarrollar nuevos compuestos terapéuticos.
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    Developments with multi-target drugs for Alzheimer’s disease: an overview of the current discovery approaches
    (Expert Opinion on Drug Discovery, 2019) Sánchez Montero, José; González Matilla, Juan Francisco; Alcántara León, Andrés Rafael; Doadrio Villarejo, Antonio Luis; Sánchez Montero, José
    Introduction: Alzheimer’s disease (AD), the most common type of dementia among older adults, is a chronic neurodegenerative pathology that causes a progressive loss of cognitive functioning with a decline of rational skills. It is well known that AD is multifactorial, so there are many different pharmacological targets that can be pursued. Areas covered: The authors highlight the strategic value of privileged scaffolds in a multi-target lead compound generation against AD, exploring the concept of multi-target design, with a special emphasis on hybrid compounds. Hence, the most promising building blocks for designing and synthesizing hybrid anti-AD drugs are shown, while also presenting the more advanced hybrid compounds. Expert opinion: The available therapeutic arsenal for AD, designed under the traditional paradigm of ‘one-drug/one target/one-disease’, is based on the inhibition of brain acetylcholinesterase (AChE) to increase acetylcholine (ACh) levels. However, this classical approach has not been sufficiently effective when used to treat any multifactor-depending pathology (cancer, diabetes or AD). The multi-target drug concept has been quickly adopted by medicinal chemists. The basic research developments reported in recent years are a solid foundation that will pave the way for the construction of future AD therapeutics.
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    Project number: 138
    Elaboración de una tabla periódica interactiva de los elementos químicos y de sus propiedades ordenadas con acceso por internet
    (2017) Doadrio Villarejo, Antonio Luis; Izquierdo Barba, Isabel; Colilla Nieto, Montserrat; Martínez Alonso, África; Sánchez Salcedo, Sandra; García Fontecha, Ana; Cabañas Criado, María Victoria; Peña López, Juan; Román Zaragoza, Jesús; Salinas Sánchez, Antonio Jesús; Doadrio Villarejo, Juan Carlos; Gutiérrez Ríos, María Teresa; Arcos Navarrete, Daniel; Moreno Pérez, José Manuel; Vallet Regí, María Dulce Nombre; Sánchez Montero, José
    Se ha construido una base de datos con las propiedades de los elementos químicos, isótopos naturales y artificiales de los elementos y el tiempo de semivida de los radiactivos, así como, la serie de la tabla periódica a la que pertenecen, carácter metálico/no metálico/metaloide, configuración electrónica y número atómico, etimología, descubridor y año de descubrimiento de cada elemento químico y de alguna/s de sus características o curiosidades más significativas.
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    Biotechnology: Impact on our Life
    (Drug Design Development and Delivery Journal, 2018) Sánchez Montero, José; Sánchez Montero, José
    Este trabajo aborda el uso prevalente del término "Biotecnología", evidente en los 6,480,000 resultados en Google, reflejando su integración en discusiones en diversas plataformas. El creciente interés en la biotecnología en ámbitos académicos y empresariales ha llevado a diversas definiciones, unidas por la utilización de seres vivos, procesos o productos con fines comerciales. La OCDE define la biotecnología como la aplicación de ciencia y tecnología a organismos vivos para alterar materiales con fines de producción de conocimiento, bienes y servicios. La biotecnología abarca diversos sectores como agricultura, alimentos, medio ambiente, producción industrial y energía, mostrando su naturaleza multidisciplinaria. El documento enfatiza el auge de la biotecnología blanca en la industria farmacéutica, utilizando sistemas biológicos para producir productos farmacéuticos. La biocatálisis, ejemplificada por el uso de enzimas, surge como alternativa a los procesos químicos convencionales, ofreciendo beneficios económicos y ambientales. La discusión se extiende a la controversia en torno a los alimentos transgénicos, explorando argumentos a favor y en contra de su uso. El documento también profundiza en los avances y desafíos en genómica, medicina personalizada y terapias génicas, ilustrando el impacto de la biotecnología en diversos aspectos de la vida humana y el medio ambiente. En general, el término "Biotecnología" se ha vuelto fundamental para abordar desafíos globales como el hambre, las enfermedades y la mejora general de la calidad de vida.
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    Drug Release from Ordered Mesoporous Silicas
    (Current Pharmaceutical Design, 2015) Doadrio Villarejo, Antonio Luis; Salinas Sánchez, Antonio Jesús; Sánchez Montero, José; Vallet Regí, María Dulce Nombre
    The state-of-the-art in the investigation of drugs release from Silica-based ordered Mesoporous Materials (SMMs) is reviewed. First, the SMM systems used like host matrixes are described. Then, the model drugs studied until now, including their pharmacological action, structure and the mesoporous matrix employed for each drug, are comprehensively listed. Next, the factors influencing the release of drugs from SMMs and the strategies used to control the drug delivery, specially the chemical functionalization of the silica surface, are discussed. In addition, how all these factors were gathered in a kinetic equation that describes the drug release from the mesoporous matrixes is explained. The new application of molecular modeling and docking in the investigation of the drug delivery mechanisms from SMMs is also presented. Finally, the new approaches under investigation in this field are mentioned including the design of smart stimuli-responsive materials and other recent proposals for a future investigation.
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    A molecular model to explain the controlled release from SBA-15 functionalized with APTES
    (Microporous and Mesoporous Materials, 2014) Doadrio Villarejo, Antonio Luis; Sánchez Montero, José; Doadrio Villarejo, Juan Carlos; Salinas Sánchez, Antonio Jesús; Vallet Regí, María Dulce Nombre
    A molecular model with the approximate pore diameter of SBA-15 was constructed for the first time to investigate the effect of functionalize the matrix with 3-aminopropyl-triethoxy-silane (APTES) in the release of Chicago Sky Blue 6B (CSB). It was expected that the positively charged amino groups of APTES could interact with the negatively charged sulphonic groups of CSB allowing controlling the release process. Indeed the experimental study showed that the release kinetics of CSB from SBA-15-APTES is two orders of magnitude smaller than from native SBA-15. However molecular modelling calculations investigating the possible interactions of APTES and SBA-15 yield unexpected results. In the model including only the condensation between the silanol groups of SBA-15 and APTES, the calculated interaction energy of CSB was quite similar than with the model of native SBA-15. However when additional electrostatic interactions of the -NH2 groups of APTES with the mesoporous matrix were modelled the mesoporous channels underwent a considerable deformation. These results point to the structure deformation as the cause of the greater retention of CSB in SBA-15-APTES and warn about the special features of AFTES when used to functionalize mesoporous silica materials. The model built in this paper could be used to construct predictive models in analogous drug delivery systems. (C) 2014 Elsevier Inc. All rights reserved.