Docking studies for melatonin receptors
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2018
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Taylor and Francis
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Awad Alkozi Hanan, Sánchez Montero José Maria, Doadrio Antonio Luis, Jesus Pintor. Docking studies for melatonin receptors, Expert Opinion on Drug Discovery. 2017 January 13 (3), 241-48
Abstract
La melatonina es una neurohormona que controla muchos procesos fisiológicos relevantes más allá del control de los ritmos circadianos. Las acciones de la melatonina son llevadas a cabo por dos tipos principales de receptores de melatonina: MT1 y MT2. Estos receptores son importantes, no solo debido a las acciones biológicas de su agonista natural, sino también porque los análogos de melatonina pueden mejorar o antagonizar su efecto biológico.
El siguiente artículo describe la importancia de la melatonina como una molécula biológicamente relevante. También define los receptores para esta sustancia, así como los segundos mensajeros acoplados a estos receptores. Por último, el artículo describe los residuos de aminoácidos involucrados en el proceso de acoplamiento en los receptores de melatonina MT1 y MT2.
Las acciones biológicas de la melatonina y sus interpretaciones están volviéndose más relevantes y, por lo tanto, requieren el desarrollo de nuevas herramientas farmacológicas. Comprender los mecanismos de los segundos mensajeros involucrados en las acciones de la melatonina, así como las características del acoplamiento de esta molécula a los receptores de melatonina MT1 y MT2, permitirá el desarrollo de agonistas y antagonistas más selectivos que nos ayudarán a comprender mejor esta molécula y a desarrollar nuevos compuestos terapéuticos.
Introduction: Melatonin is a neurohormone that controls many relevant physiological processes beyond the control of circadian rhythms. Melatonin’s actions are carried out by two main types of melatonin receptors; MT1 and MT2. These receptors are important, and not just because of the biological actions of its natural agonist; but also, because melatonin analogues can improve or antagonize their biological effect. Area covered: The following article describes the importance of melatonin as a biologically relevant molecule. It also defines the receptors for this substance, as well as the second messengers coupled to these receptors. Lastly, the article describes the amino acid residues involved in the docking process in both MT1 and MT2 melatonin receptors. Expert opinion: The biological actions of melatonin and their interpretations are becoming more relevant and therefore require the development of new pharmacological tools. Understanding the second messenger mechanisms involved in melatonin actions, as well as the characteristics of the docking of this molecule to MT1 and MT2 melatonin receptors, will permit the development of more selective agonists and antagonists which will help us to better understand this molecule as well to develop new therapeutic compounds.
Introduction: Melatonin is a neurohormone that controls many relevant physiological processes beyond the control of circadian rhythms. Melatonin’s actions are carried out by two main types of melatonin receptors; MT1 and MT2. These receptors are important, and not just because of the biological actions of its natural agonist; but also, because melatonin analogues can improve or antagonize their biological effect. Area covered: The following article describes the importance of melatonin as a biologically relevant molecule. It also defines the receptors for this substance, as well as the second messengers coupled to these receptors. Lastly, the article describes the amino acid residues involved in the docking process in both MT1 and MT2 melatonin receptors. Expert opinion: The biological actions of melatonin and their interpretations are becoming more relevant and therefore require the development of new pharmacological tools. Understanding the second messenger mechanisms involved in melatonin actions, as well as the characteristics of the docking of this molecule to MT1 and MT2 melatonin receptors, will permit the development of more selective agonists and antagonists which will help us to better understand this molecule as well to develop new therapeutic compounds.
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Este articulo fue realizado por invitación expresa de la editorial sin coste alguno