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Item Determining and characterizing circulating nucleosomes in advanced cancer with electrochemical biosensors assisted by magnetic supports and proteomic technologies(Biosensors and Bioelectronics, 2025) Tejerina Miranda, Sandra; Carral Ibarra, Elisa; Gamella Carballo, María; Montero Calle, Ana; Pedrero Muñoz, María; Pingarrón Carrazón, José Manuel; Barderas Manchado, Rodrigo; Campuzano Ruiz, SusanaMeasuring and monitoring plasma nucleosomes (small fragments of chromosomes released into the blood during cell death), and their proteomic profiles is a promising approach for improved early detection, diagnosis, and prognosis of cancer diseases as well as for disease and therapy follow-up, contributing to more personalized and effective cancer care. Early detection is imperative in colorectal cancer (CRC), as it has been proven to significantly improve patient outcomes. Indeed, in CRC, blood circulating nucleosome levels and their histone alterations have been correlated with tumor stage and the presence of metastasis. Moreover, they constitute promising markers for CRC monitoring and prognosis in a minimally invasive way. The current technologies used for their detection suffer from notable drawbacks such as non-selective identification and quantification of unknown cancer-relevant proteomic trademarks, expensive procedures, and variable results related to staff experience. Taking advantage of the sensitive, fast, cost-effective, and reliable methodologies that electroanalytical technologies offer for the determination of multilevel biomarkers in liquid biopsies, we report in this paper the first electrochemical immunoplatform for the isolation and determination of circulating nucleosomes in plasma using an anti-H3.1 histone variant, integrated with proteomics insights to confirm nucleosomes isolation and identify associated proteins with potential as CRC biomarkers. The developed bioplatform was used to analyze 0.5 μg of nuclear extracts from CRC cells with different metastatic potential as well as 1/5 diluted plasma samples, demonstrating the suitability to effectively discriminate CRC patients in advanced stages from healthy individuals through liquid biopsy.Item Una revisión de la literatura académica: 20 años de la política exterior del gobierno del Partido de la Justicia y el Desarrollo (AKP) en Turquía(Revista de estudios internacionales mediterráneos, 2022) Lois Barrio, María Dolores; Rodríguez López, CarmenEl siguiente texto lleva a cabo una revisión de la literatura académica centrada en la política exterior del AKP en el periodo 2002-2022 con el objeto de contextualizar el contenido del monográfico especial “Turquía: repertorios de cooperación y conflicto en el Mediterráneo oriental y la región MENA”. El monográfico se centra en abordar los repertorios de actuación de Turquía en el ámbito de su política exterior, muy especialmente durante episodios contenciosos, pero no sólo, con terceros Estados. Con el objeto de contextualizar las relaciones bilaterales objeto de análisis, el presente artículo recoge las principales tendencias en la política exterior turca de los últimos años, con las que enmarcar y explicar el contexto en el que se producirán dichas relaciones, así como el recurso a diferentes herramientas de poder político en la arena internacional. Esta visión panorámica permite ahondar en la dirección y alcance de unas relaciones exteriores que han experimentado transformaciones sustanciales en los últimos años. El artículo se centra en los textos que han propuesto una caracterización por etapas de la política exterior del AKP, plantea en detalle la génesis y el debate en torno a los conceptos de neo-otomanismo y euroasianismo comúnmente utilizados para explicardiferentes momentos de la política exterior turca, y cierra con un epígrafe destinado a las herramientas de poder duro, poder blando y de diplomacia coercitiva utilizadas por el partido en el poder.Item “El mar nos une”: imaginarios geopolíticos y frontera marítima en el diferendo Bolivia-Chile(Scripta Nova, 2022) Lois Barrio, María DoloresEste artículo propone un acercamiento a los imaginarios geopolíticos surgidos en el contexto de la demanda jurídica presentada por Bolivia en la Corte Internacional de La Haya en 2013, resuelta en 2018. Desde un análisis crítico de discurso, este trabajo intentará mostrar como el tiempo legal, el tiempo de la demanda, abre un horizonte de diferentes planos de producción de representaciones en torno al mar y su recuperación como referente para la política exterior boliviana. En términos de materiales, se trabajará con textos y registros visuales publicados tanto por instituciones oficiales (ministerio de Justicia y Transparencia Institucional, Procuraduría General del Estado, etc.), como por actores no institucionales (artistas), así como con prácticas espaciales (el “banderazo”) con el propósito de mostrar la amplia y diversa imaginación geopolítica ligada a la demanda de un “Mar para Bolivia”.Item La atención a la diversidad cultural y de género en la formación del profesorado(Innovación Educativa, 2017) Gómez Jarabo, Inmaculada; Sánchez Delgado, PrimitivoLa situación de las aulas obliga a investigar en profundidad los fenómenos violentos para dar una respuesta adecuada a los mismos. Los y las profesionales que trabajan en los centros educativos deben estar capacitados para elaborar e implementar planes de convivencia que redunden en la mejora del clima escolar, el tratamiento educativo de los conflictos y la atención a la diversidad étnica, cultural y de género. Se desarrolló una investigación sobre la “formación del profesorado para el tratamiento educativo de los conflictos sobre diversidad cultural y de género”. El objetivo de la investigación consistía en conocer si la formación del profesorado responde a las necesidades del actual contexto socioeducativo y reflexionar sobre si es necesaria su transformación y actualización. Se utilizó una metodología prioritariamente cualitativa. Los resultados ponen de manifiesto que, aunque el profesorado participante en la investigación aprecia la diversidad y se manifiesta a favor de una escuela inclusiva que acoja a todo tipo de estudiantes, se aprecia que su formación tiene carencias importantes en temas como dinamización de grupos, tratamiento de conflictos, violencia, interculturalidad y géneroItem Formación del profesorado en cuestiones de género(Revista de Comunicación de la SEECI, 2017) Gómez Jarabo, Inmaculada; Sánchez Delgado, PrimitivoSe han conseguido muchos avances. Sin embargo, la mujer todavía está lejos de lograr una igualdad real con el hombre y, en algunos casos, sigue siendo objeto de agresiones físicas, psicológicas, verbales, sexuales… que, en ocasiones, tienen su origen en las ideas que histórica y culturalmente han sido transmitidas de generación en generación. En algunos sectores sociales es habitual la creencia de que la violencia de género no afecta a la infancia y la juventud, pero las últimas investigaciones muestran una situación diferente: los centros escolares son el escenario de los primeros abusos de género. La labor del profesorado es esencial en la detección y tratamiento de la violencia, la mejora de la convivencia escolar y la formación y sensibilización en cuestiones de género. La investigación que se presenta en este artículo pretende desvelar si el profesorado está preparado para ello y si la formación del profesorado tiene en cuenta esos aspectos. Aquí se muestran algunos resultados relevantes de una investigación sobre la “formación del profesorado para el tratamiento educativo de los conflictos sobre diversidad cultural y de género”, en la que se utilizó una metodología mixta de investigación. Los resultados ponen de manifiesto que existen carencias importantes en la formación del profesorado en relación a cuestiones de género, convivencia entre sexos, gestión de conflictos y violencia.Item The more i feel the experience, the more i buy(International Journal of Humanities and Social Science, 2013) Gavilán Bouzas, Diana; Avello Iturriagagoitia, María; Abril Barrie, María Del CarmenShopping behaviour and shopping malls have received significant attention in the academic literature in the past years. At the same time, Experiential Marketing knowledge has proven to be essential for the understanding of consumer behaviour. Despite the importance achieved by the aforementioned topics, the depiction of shopping mall consumers attending to the way they live the shopping experience is still scarce. This study conducts a segmentation analysis with latent class clusters to reveal four shopping segments: "Charmed by Experience", "Explorers", "Social Interactive" and "Disappointed" shoppers. The results suggest that customers experience the mall differently, and that their purchasing behaviour differs in expenditure, visit duration, planned and unplanned purchases, and re-patronage intention. The findings of the research are discussed for future academic research and to assist retailers in the definition of strategies addressed to enhancing shopping experiences among different type of customers.Item Pincelando nuevos horizontes en salud de precisión con tecnologías (bio)electroanalíticas vanguardistas / Painting new horizons for precision healthcare with cutting-edge (bio)electroanalytical technologies(Anales de Química de la RSEQ Revista de la Real Sociedad Española de Química, 2025) Campuzano Ruiz, Susana; Torrente Rodríguez, Rebeca Magnolia; Ruiz Valdepeñas Montiel, Víctor; Povedano Muñumel, Eloy; Montero Calle, Ana; Garranzo Asensio, María; Gamella Carballo, María; Serafín González-Carrato, Verónica; Barderas Manchado, Rodrigo; Pedrero Muñoz, María; Pingarrón Carrazón, José ManuelLos grandes avances experimentados en el desarrollo de tecnologías (bio)electroanalíticas vanguardistas, confiables y multipropósito y su incursión exitosa en escenarios poco explorados han demostrado su potencial único para actuar de facilitadoras de una salud de vanguardia y de sistemas sanitarios más eficientes y sostenibles. Es en este contexto esperanzador en el que se enfoca este artículo preparado por invitación por el reconocimiento con uno de los “premios a la Excelencia investigadora” otorgados por la RSEQ en su edición 2024 a las investigaciones que he tenido la suerte de orquestar en compañía de los mejores colaboradores, y en el que, además de destacarse algunas de las más representativas, se ofrece una visión personal y generosa de los propósitos inminentes.Item Engineering a multifunctional hybrid polymer-hydrogel nanocomposite for high-sensitivity, anti-fouling electrochemical immunodetection in early cancer diagnosis(Sensors and Actuators B: Chemical, 2025) Serafín González-Carrato, Verónica; Cabrero Martín, Andrea; Santiago, Sara; Yildiz, Ceren; Pedrero Muñoz, María; Montero Calle, Ana; Yazan, Zehra; Dilek Eskiköy Bayraktepe; Pingarrón Carrazón, José Manuel; Barderas Manchado, Rodrigo; Campuzano Ruiz, SusanaThis work introduces a novel dual-component electrode modifier comprising gold nanoparticles (AuNPs) and a hydrated form of the poly(3,4-ethylenedioxythiophene) (hPEDOT) conducting polymer to enhance biomolecule immobilization and signal amplification in electrochemical immunosensing. The thiophene–AuNP interaction promotes electropolymerization, forming a citrate-doped matrix with carboxyl groups that enable covalent, oriented antibody anchoring. Moreover, the hydration of the polymeric scaffold enhances the biocompatibility and anti-fouling properties of the sensing interface. This multifunctional polymer–hydrogel nanocomposite was used to develop a disposable sandwich-type electrochemical immunoplatform for the determination of human endostatin (HE), a biomarker of colorectal cancer (CRC). The immunoplatform achieved a detection limit of 0.04 ng mL⁻1 and distinguished not only healthy individuals from early-stage CRC patients but also from those with premalignant colorectal lesions. These findings underscore the potential of this new multifunctional hybrid nanocomposite to improve the performance of electrochemical immunosensing, which is crucial for timely cancer diagnosis and intervention.Item Tracking globally 5-methylcytosine and its oxidized derivatives in colorectal cancer epigenome using bioelectroanalytical technologies(ACS Sensors, 2025) Povedano Muñumel, Eloy; Pérez Ginés, Víctor; Torrente Rodríguez, Rebeca Magnolia; Montero Calle, Ana; Peláez García, Alberto; Feliú, Jaime; Pedrero Muñoz, María; Pingarrón Carrazón, José Manuel; Barderas Manchado, Rodrigo; Campuzano Ruiz, SusanaThis work presents the first electroanalytical bioplatforms to track individually or simultaneously at a global level all four methylation marks involved in the DNA methylation–demethylation cycle: 5-methylcytosine (5mC) and their sequential oxidative derivatives (5-hydroxymethyl-(5hmC), 5-formyl-(5fC), and 5-carboxyl-(5caC) cytosines). The bioplatforms employed direct competitive immunoassay formats implemented on the surface of magnetic microparticles (MBs) and involved capture antibodies specific to each epimark as well as synthetic biotinylated DNA oligomers with a single epimark that were enzymatically marked with horseradish peroxidase (HRP) to perform an amperometric readout on disposable platforms for single or multiplexed detection. These new electroanalytical biotechnologies, groundbreaking from analytical and clinical perspectives, achieved attractive operational characteristics, reaching detection limits at pM levels for synthetic single epimark-bearing DNA oligomers. The developed methodology was applied to track globally all four target epimarks in a fast, simple, sensitive, and selective way while their correlation in genomic DNA extracted from paired healthy and tumor tissues of patients with colorectal cancer (CRC) was established for the first time.Item A robust multiplicity result in a generalized diffusive predator-prey model(Advances in Differential Equations, 2024) López Gómez, Julián; Muñoz Hernández, EduardoThis paper analyzes the generalized spatially heterogeneous diffusive predator-prey model introduced by the authors in [24],whose interaction terms depend on a saturation coefficient $m(x)\gneq0$. As the amplitude of the saturation term, measured by $\|m\|_{\infty}$, blows up to infinity, the existence of, at least, two coexistence states, is established in the region of the parameters where the semitrivial positive solution is linearly stable, regardless the sizes and the shapes of the remaining function coefficients in the setting of the model. In some further special cases, an $S$-shaped component of coexistence states can be constructed, which causes the existence of, at least, three coexistence states, thoughthis multiplicity occurs within the parameter regions where the semitrivial positive solution is linearly unstable. Therefore, these multiplicity results inherit a rather different nature.Item Filmar para tajar: Madrid en el cine en torno al 15-M(Cahiers de civilisation espagnole contemporaine (de 1808 au temps présent), 2022) Deltell Escolar, LuisEste artículo investiga acerca del retrato que el cine y el audiovisual surgido en torno al movimiento 15-M hicieron de la ciudad de Madrid. Por un lado, se analizan las obras de los colectivos artísticos que nacieron como respuesta ante las primeras manifestaciones de los indignados, después se aborda las obras de los cineastas consagrados que se acercaron a esta temática y, por último, se indaga en el devenir estético y temático de las siguientes piezas de estos creadores. La hipótesis central es que estas películas intentan interpretar la historia reciente –en especial la Transición– y la ciudad de Madrid no como lugares neutrales o apacibles, sino como espacios de conflicto y de lucha. Los cineastas analizados filman para tajar o cortar con la interpretación habitual de la historia y la ciudad.Item Cardiolipin acyl chain composition tailors the conformation of mammalian ATP synthase dimers(Communications Chemistry, 2025) Makowski, M.; Almendro Vedia, Víctor Galileo; López Montero, IvánThe interplay between ATP synthase dimers and the four-tailed lipid cardiolipin (CL) shapes mitochondrial cristae structure and function. In the mitochondrial disorder Barth syndrome (BTHS), cristae membranes accumulate a less unsaturated, three-tailed form of cardiolipin (MLCL). These cristae become structurally and functionally compromised through mechanisms poorly understood. We have studied through molecular dynamics simulations how BTHS lipid composition affects the conformation of the ATP synthase dimer. The wedge-shaped transmembrane region of the ATP synthase dimer attracts cardiolipins through shape complementarity. MLCL showed decreased affinity for the dimer interface than CLs of the healthy model. A more heterogeneous lipid environment with a higher elastic strain promoted a dimer conformation that would stabilize wider intracrista spaces, and hence, less efficient OXPHOS reactions in BTHS. Our results provide clues on the role played by the CL acyl chain composition in the architecture and function of mitochondria in health and BTHS.Item Multifunctional cerium nanolabels in electrochemical immunosensing with improved robustness and performance: determination of TIM‑1 in colorectal cancer scenarios as a case study(Microchimica Acta, 2025) Cabrero Martín, Andrea; Santiago, Sara; Serafín González-Carrato, Verónica; Pedrero Muñoz, María; Montero Calle, Ana; Pingarrón Carrazón, José Manuel; Barderas Manchado, Rodrigo; Campuzano Ruiz, SusanaA multifunctional cerium oxide nanoparticles (CeO2NPs)-based nanolabel is exploited to implement an electrochemical sandwich-type immunoplatform for the determination of T-cell immunoglobulin and mucin domain 1 (TIM-1) biomarker, a mucin-like class I membrane glycoprotein associated with cancer angiogenesis. The immunoplatform is constructed using screen-printed electrodes where capture antibody is immobilized through the chemistry of diazonium salts. CeO2NPs exhibit robust pseudo-peroxidase activity even at high substrate concentrations. They are covalently functionalized in a simple manner after carboxylation with a detector antibody (dAb), acting dually as a nanozyme and nanocarrier for sensing bioreceptors. This allows the development of immunoplatforms with improved robustness and performance (in terms of a moderate enhancement in sensitivity, a significant expansion in the linear range, and a reduction in the background current) compared with the immunoplatforms prepared using nanolabels also decorated with the natural enzyme (horseradish peroxidase, HRP) or the conventional enzymatic labeling involving the dAb and an HRP-secondary antibody. Under the optimized experimental conditions, the developed electrochemical immunoplatform allows the highly sensitive detection of the TIM-1 glycoprotein, with a detection limit of 9.9 pg mL−1 and a linear working range of 33–600 pg mL−1. This performance permits biomarker quantification within clinically relevant ranges. This innovative configuration enables the precise diagnosis and stratification of colorectal cancer patients by analyzing plasma samples without pretreatment beyond a sample dilution and allows establishment of the first cut-off values reported for this purpose.Item Minimal complexity and chaos in periodic predator-prey models(Rendiconti del Seminario Matematico di Torino, 2023) López Gómez, Julián; Muñoz Hernández, EduardoThis paper presents and discusses at the light of the existing literature some recent results of the authors together with F. Zanolin on the construction of chaotic dynamics for some classical periodic predator-prey systems. In Section 1 we remember, with gratitude, the genesis of these findings.Item Unlocking the potential of NH2-MIL-101 (Fe) nanoMOF for advanced electrochemical immunosensing in chronic wound diagnostics(2025) Pérez Ginés, Víctor; Valero-Calvo, David; Torrente Rodríguez, Rebeca Magnolia; Pedrero Muñoz, María; García Alonso, Francisco J.; Pingarrón Carrazón, José Manuel; Campuzano Ruiz, Susana; Escosura Muniz, Alfredo de laIn this work we take advantage, for the first time, of the porous and functional structure of a nanoscale metal organic framework (nanoMOF), specifically NH2-MIL-101 (Fe) nanoMOF, for its use as advantageous enzyme-carrier nanotag in immunoassays. In particular, the porous structure of the nanoMOF allows accommodating a high loading of enzyme molecules, which, in addition, are protected from degradation inside the pores providing a high stability. This property together with the ability of the nanoMOF to link antibodies through its functional groups make it a very robust and powerful label. Both the enhanced sensitivity, compared with the conventional use of enzyme-labelled antibodies, and the high long-term stability are demonstrated. Such nanotag also offers advantages related to ease of modification and cost effectiveness. The detection of myeloperoxidase (MPO), a key biomarker for chronic wound monitoring, is proposed to demonstrate the applicability of this approach. A sandwich-type immunoassay using magnetic beads (MBs)-based platforms and subsequent amperometric detection allows the determination of MPO in the clinical range (5 – 100 ng mL−1), with a limit of detection of 1.4 ng mL−1, and good reproducibility (RSD(n = 10) = 7.1 %). The developed bio-strategy also exhibits high selectivity against potential interferents and a good stability of the nanotag for at least 2 months. Moreover, the developed method was successfully implemented to determine MPO in simulated chronic wound matrices, demonstrating its feasibility in a real scenario.Item Hierarchical Au@Pt nanoparticle/amino benzoic acid polymer‑based hybrid material for labeled and label‑free detection of interleukin‑6: a comparative assessment(Microchimica Acta, 2024) Soto, Dayana; Serafín González-Carrato, Verónica; Pedrero Muñoz, María; Pingarrón Carrazón, José Manuel; Campuzano Ruiz, Susana; Orozco, JahirInterleukin-6 (IL6) is a cytokine mainly involved in inflammatory processes associated with various diseases, from rheumatoid arthritis and pathogen-caused infections to cancer, where malignant cells exhibit high proliferation and overexpression of cytokines, including IL6. Furthermore, IL6 plays a fundamental role in detecting and differentiating tumor cells, including colorectal cancer (CRC) cells. Therefore, given its range of biological activities and pathological role, IL6 determination has been claimed for the diagnosis/prognosis of immune-mediated diseases. Herein, a comparative study is presented of labeled and label-free electrochemical immunosensors involving a hierarchical Au@Pt nanoparticle/polymer hybrid material for detecting IL6. The electrochemical immunosensors were independently coupled to the surface of screen-printed carbon electrodes (SPCEs) previously modified with polymeric layers. While in the label-free immunosensor, an anti-IL6 antibody (IL6-Ab) was covalently bound to the modified SPCE surface, in the sandwich-like amperometric immunosensor, an anti-biotinylated-IL6 antibody (B-IL6-Ab) was attached to the electrode through biotin-avidin affinity interactions. The label-free format employed a straightforward detection of IL6 by differential pulse voltammetry (DPV). The resulting electrochemical immunosensors exhibited a linear dynamic range from 50 to 750 pg/mL IL6, with detection limits (LOD) of 14.4 and 6.0 pg/mL for label-free and sandwich-like immunosensors, respectively. This outstanding performance makes them versatile platforms for clinical analysis of a panel of biomarkers for early diagnosis/prognosis of inflammatory processes associated with oncological diseases, among other pathologies.Item Evaluation of the Effect of Hydroxyzine on Preoperative Anxiety and Anesthetic Adequacy in Children: Double Blind Randomized Clinical Trial(BioMed Research International, 2021) Aleo Luján, Esther; Picado, Amanda López; Abancens, Belén Joyanes; Soto Beauregard, María Del Carmen; Tur Salamanca, Nuria; Esteban Polonios, Carmen; Torrejón, María José; Perrino, Carlos González; Rivas Paterna, Ana Belén; Arias, Eva; Rodríguez, Diamelis; Rivas, Mª. Ángeles; Rojo, Marina Laura Rodríguez; García, Patricia Fernández; Alarcón, Jaime Rodríguez; San Pedro de Urquiza, BorjaSurgical procedures can generate significant preoperative anxiety (POA) in as much as 70% of the paediatric population. The role of hydroxyzine and distractive techniques such as clowns in the management of anxiety is controversial. Our main objective was to evaluate the effect of hydroxyzine on the control of POA. The secondary objective was to assess the potential additive effect of hydroxyzine and distracting techniques. We performed a randomized double-blind, controlled clinical trial in children aged 2–16 years undergoing outpatient surgery (n = 165). Subjects were randomized to hydroxyzine (group 1) or placebo (group 2). For the secondary objective, two further groups were made by allocation by chance to hydroxyzine plus accompaniment with clowns (group 3) and placebo plus clowns (group 4). All patients were accompanied by their parents as the standard procedure. POA was determined by a modified Yale scale of POA (m-YPAS). Compliance of children during induction of anesthesia (Induction Compliance Checklist (ICC)) was also assessed. No differences (p = 0.788) were found in POA control at the time of induction measured by m-YPAS (group 1: 39.2 ± 27.9; group 2: 37.0 ± 26.1; group 3: 34.7 ± 25.5; group 4: 32.4 ± 20.5). No differences were found in the level of ICC between the different treatment arms (group 1: 1.8 ± 3.4; group 2: 1.5 ± 3.0; group 3: 1.2 ± 2.4; group 4: 1.5 ± 2.7). The combination of all treatments (group 3) was the only effective strategy to contain the progression of anxiety. In conclusion, hydroxyzine was not effective to control POA in children. The combination of hydroxyzine and clowns avoided the progression of POA in our patients. This trial is registered with ClinicalTrials.gov identifier: NCT03324828 (registered 21 September 2017, subject recruitment started on 12th January 2018).Item Estudiando la senescencia celular en cáncer colorrectal con inmunosensado electroquímico moderno(ACTUALIDAD ANALÍTICA, 2024) Pedrero Muñoz, María; Tejerina Miranda, Sandra; Gamella Carballo, María; Montero Calle, Ana; Pingarrón Carrazón, José Manuel; Barderas Manchado, Rodrigo; Campuzano Ruiz, SusanaCon la edad, en un número creciente de células del organismo se producen daños en el DNA que derivan en senescencia celular [1]. Las células senescentes se acumulan en los tejidos creando microambientes protumorales y aumentando la expresión de diversos biomarcadores, entre los que cabe destacar el factor de diferenciación de crecimiento 15 (GDF-15) y el inhibidor tisular de la metaloproteinasa 1 (TIMP-1), ambos implicados en procesos de senescencia celular y metástasis en cáncer colorrectal (CRC) [2-4]. Con el propósito de profundizar en el papel de dichos biomarcadores en estos procesos, recientemente se han desarrollado inmunoplataformas electroquímicas aplicadas con éxito al análisis de extractos y secretomas de células de CRC con diferente capacidad metastásica y de plasma y tejido de pacientes con CRC en distintos estadios. Los resultados obtenidos han puesto en valor el papel que juegan estos dos biomarcadores en el entendimiento y tratamiento de estos trastornos.Item Coupled reaction-diffusion equations with degenerate diffusivity: wavefront analysis(Nonlinearity, 2025) Muñoz Hernández, Eduardo; Sovrano, Elisa; Taddei, ValentinaWe investigate traveling wave solutions for a nonlinear system of two coupled reaction-diffusion equations characterized by double degenerate diffusivity: \[n_t= -f(n,b), \quad b_t=[g(n)h(b)b_x]_x+f(n,b).\] These systems mainly appear in modeling spatial-temporal patterns during bacterial growth. Central to our study is the diffusion term $g(n)h(b)$, which degenerates at $n=0$ and $b=0$; and the reaction term $f(n,b)$, which is positive, except for $n=0$ or $b=0$. Specifically, the existence of traveling wave solutions composed by a couple of strictly monotone functions for every wave speed in a closed half-line is proved, and some threshold speed estimates are given. Moreover, the regularity of the traveling wave solutions is discussed in connection with the wave speed.Item Wikipedia y los museos de la Subdirección General de Bellas Artes(Arte, Individuo y Sociedad, 2020) Deltell Escolar, Luis; Claes, FlorenciaSe trata de una investigación en torno al discurso online creado en Wikipedia sobre los centros que dependen de la Subdirección General de Bellas Artes, es decir, los denominados Museos Estatales, el Museo Nacional del Prado, el Museo Nacional Centro de Arte Reina Sofía y el Museo Lázaro Galdiano. Se analiza la posible creación de un discurso libre. Se trata de contrastar el concepto Open Authority (autoridad libre) expuesto por Lori Byrd Phillips. Se han monitorizado las entradas, los artículos y la construcción de debate en todas las versiones idiomáticas de la enciclopedia online durante tres años. Además, se ha valorado la calidad de los artículos analizados. También se ha observado el comportamiento de los usuarios, o wikipedistas, que han participado en estas entradas. Nuestras conclusiones reflejan como Wikipedia es un lugar de creación libre sobre los discursos de los museos de arte.