Person:
Gil Ordóñez, Ana

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First Name
Ana
Last Name
Gil Ordóñez
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Ciencias Químicas
Department
Química Inorgánica
Area
Química Inorgánica
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    New strategies for the treatment of cellular senescence
    (Universidad Complutense de Madrid, 2019-12-16) Gil Ordóñez, Ana; López Rodríguez, María Luz; Ortega Gutiérrez, Silvia; Martín-Fontecha Corrales, María del Mar
    Cellular senescence is a biological irreversible process that appears after cellular stress and stops the proliferation of dysfunctional or damaged cells. Senescent cells are accumulated in our body with aging, so the regulation of this process could have an important effect in health span and aging. Towards this end, in the present work we propose two different approaches. In the first one (Chapter A), the objective is the development of inhibitors of isoprenylcysteine carboxyl methyltransferase (ICMT) enzyme for targeting progeria as a model of accelerated aging. In the second approach (Chapter B), and taking into account the possible influence that metabolites of the human microbiota can have in aging, we propose an innovative strategy for the identification of microbiota metabolites in the framework of a broader project aimed at the phenotypic study of the identified metabolites in senescence...