Person: Hernández García, Elena
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First Name
Elena
Last Name
Hernández García
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Medicina
Department
Inmunología, Oftalmología y ORL
Area
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6 results
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Item Estudio de motilidad ocular, agudeza visual, visión binocular y calidad de vida en pacientes con glaucoma congénito(2019) Hernández García, Elena; García Feijóo, Julián; Gómez de Liaño Sánchez, María Rosario; Morales Fernández, LauraEl glaucoma congénito primario (GCP) es una patología poco frecuente. Este tipo de glaucoma se caracteriza por la corta edad al diagnóstico, la mala respuesta al tratamiento médico y el alto requerimiento de cirugías antiglaucomatosas. Una vez alcanzado el control de la presión intraocular, un factor importante que influye en el pronóstico visual final es la aparición de la ambliopía. Es fundamental la evaluación de la agudeza visual, de la refracción y de las posibles causas de ambliopía, como la anisometropía y el estrabismo, puesto que permite completar el tratamiento integral de estos pacientes, crítico en la edad en que se ve afectado su desarrollo por la enfermedad, incrementando su pronóstico visual a largo plazo..Item Inoculation of the Leishmania infantum HSP70-II Null Mutant Induces Long-Term Protection against L. amazonensis Infection in BALB/c Mice(Microorganisms, 2021) Soto, Manuel; Ramírez, Laura; Solana, José Carlos; Cook, Emma C. L.; Hernández García, Elena; Requena, José María; Iborra Martín, SalvadorLeishmania amazonensis parasites are etiological agents of cutaneous leishmaniasis in the New World. BALB/c mice are highly susceptible to L. amazonensis challenge due to their inability to mount parasite-dependent IFN-γ-mediated responses. Here, we analyzed the capacity of a single administration of the LiΔHSP70-II genetically-modified attenuated L. infantum line in preventing cutaneous leishmaniasis in mice challenged with L. amazonensis virulent parasites. In previous studies, this live attenuated vaccine has demonstrated to induce long-protection against murine leishmaniasis due to Old World Leishmania species. Vaccinated mice showed a reduction in the disease evolution due to L. amazonensis challenge, namely reduction in cutaneous lesions and parasite burdens. In contrast to control animals, after the challenge, protected mice showed anti-Leishmania IgG2a circulating antibodies accompanied to the induction of Leishmania-driven specific IFN-γ systemic response. An analysis performed in the lymph node draining the site of infection revealed an increase of the parasite-specific IFN-ϒ production by CD4+ and CD8+ T cells and a decrease in the secretion of IL-10 against leishmanial antigens. Since the immunity caused by the inoculation of this live vaccine generates protection against different forms of murine leishmaniasis, we postulate LiΔHSP70-II as a candidate for the development of human vaccines.Item Lifestyle Factors in Myopic Spanish Children(Children, 2024) Güemes-Villahoz, Noemí; Gómez De Liaño Sánchez, María Rosario; Porras Ángel, Paloma; Talavero González, Paula; Bella Gala, Rafael; Martín García, Beatriz; Burgos Blasco, Bárbara; Hernández García, Elena; Chamorro Herrera, Marta; Hernández Verdejo, José Luis; Ruiz Pomeda, Alicia; MDPIBackground: Childhood myopia represents a global concern with increasing prevalence in recent decades. Lifestyle factors significantly impact myopia. Aim: To evaluate lifestyle factors in myopic children from a metropolitan area in Europe. Methods: This was a descriptive study including myopic subjects aged 4–18 years. Patient demographic and clinical data were collected, including cycloplegic refraction in spherical equivalent refraction (SER) and axial length (AL). In addition, a questionnaire on lifestyle factors was conducted between September 2022 and April 2023. Results: A total of 321 myopic children were included, aged 10.72 ± 3.05 years, of whom 51.4% were boys, with SER −2.25 ± 1.9 D and AL 24.54 ± 0.98 mm. The mean age of myopia onset was 7.69 ± 3.05 years. A total of 59.8% had family history of myopia. Those children who had <2 h/day of screen time (on weekdays) presented SER −2 ± 1.91 D, compared to those who had >2 h/day, SER: −2.50 ±1.88 D (p = 0.009). Children who spent <2 h/day doing near work after school were less myopic compared to those who spent >2 h/day (SER: −1.75 ± 1.83 vs. SER: −2.75 ± 1.82, respectively, p = 0.03). However, no significant association was observed between SER and AL and time spent outdoors nor between SER and AL and academic performance (p > 0.05). Conclusions: Screen time and near-work time appear to be lifestyle factors related to myopia.- Project number: 238
Item Presentación y discusión de trabajos científicos de respuesta inmune a la infección en congresos() García de Yébenes Mena, Virginia; Roda Navarro, Pedro; Iborra Martín, Salvador; Fernández Messina, Lola María; Fernandez Arquero, Miguel; Álvarez Corrales, Emigdio; Redondo Urzainqui, Ana; Hernández García, Elena; Aguilar Sopeña, Óscar; Carrasco Padilla, CarlosEl proyecto ha tenido como objetivo proporcionar a los alumnos del máster de Investigación en Inmunología de la UCM una formación teórica y práctica para la presentación de trabajos científicos en congresos. Se ha desarrollado una reunión científica en la que los alumnos han presentado y discutido trabajos científicos relevantes relacionados con la asignatura “Interacción Patógeno Sistema Inmunitario (607653)” en los formatos de presentación oral y presentación en póster que se utilizan en las reuniones científicas Item Quality of life and visual function in children with glaucoma in Spain(Archivos de la Sociedad Española de Oftalmología, 2018) Moreno, María Nieves; Morales Fernández, Laura; Ruiz Medrano, Magali; Martínez De La Casa Fernández-Borrella, José María; Madrigal Sánchez, Rebeca; Hernández García, Elena; Gómez de Liaño, Rosario; García Feijoo, JuliánObjective: To evaluate the effect of glaucoma on visual function, as well as quality of life in children and quality of life perceived by caregivers in children up to 16 years of age. Material and methods: An observational and prospective study was designed using the questionnaire GQL-15 (Glaucoma Quality of Life) and conducted on children and caregivers. The questionnaire VFQ-25 (Visual Functioning Questionnaire) was conducted on children. Different variables of the clinical history that could influence the quality of life and visual function were recorded. Results: The study included 24 patients with a mean age of 9.13 ± 3.08 years, and included 3 with unilateral involvement, and 20 diagnosed with primary congenital glaucoma. Parents reported a worse quality of life than children. The result of the GQL-15 survey was 32.3 ± 11.56 points in children and 37.52 ± 14.59 points in caregivers (P = .001). The parameter most related to quality of life and visual function was the mean deviation (MD) of the visual field in the best eye. A statistically significant correlation was found between the result of GQL-15 and the mean deviation of the visual field (children: R = 0.63, P < .01, caregivers: R = 0.81, P< .001). Conclusions: Functional loss has an impact on the quality of life and visual function in children with glaucoma, although the quality of life perceived by the caregivers is worse than that perceived by the child.Item Dendritic cells in energy balance regulation(Immunology Letters, 2022) Redondo Urzainqui, Ana; Hernández García, Elena; Cook, Emma Clare Laura; Iborra, SalvadorBesides their well-known role in initiating adaptive immune responses, several groups have studied the role of dendritic cells (DCs) in the context of chronic metabolic inflammation, such as in diet-induced obesity (DIO) or metabolic-associated fatty liver disease. DCs also have an important function in maintaining metabolic tissue homeostasis in steady-state conditions. In this review, we will briefly describe the different DC subsets, the murine models available to assess their function, and discuss the role of DCs in regulating energy balance and maintaining tissue homeostasis.