Person:
Romero Martínez, Manuel Alejandro

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First Name
Manuel Alejandro
Last Name
Romero Martínez
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Veterinaria
Department
Farmacología y Toxicología
Area
Toxicología
Identifiers
UCM identifierORCIDScopus Author IDWeb of Science ResearcherIDDialnet IDGoogle Scholar ID

Search Results

Now showing 1 - 10 of 17
  • Publication
    Guía de prácticas y seminarios de Fundamentos de Toxicología
    (2021) Ramos Alonso, Eva; Del Pino Sans, Javier; Romero Martínez, Manuel Alejandro; Díaz Plaza, María Jesús; Frejo Moya, María Teresa; Moyano-Cires Ivanoff, Paula Viviana
  • Publication
    Página web orientada a la evaluación “in silico” de nuevas sustancias con interés biológico. Parte II
    (2019-05-22) Romero Martínez, Manuel Alejandro; Ramos Alonso, Eva; García Cantón, Carolina; Pita Pita, Rene; Díaz Peralta, Pedro; Marco Contelles, Jose Luis; Rodriguez Martín, Abigail
  • Publication
    Página web orientada a la evaluación in silico de nuevas sustancias con interés biológico (parte V)
    (2022) Ramos Alonso, Eva; Romero Martínez, Manuel Alejandro; García Cantón, Carolina; Pita Pita, Rene; Rodríguez Martín, Abigail; Rodríguez Talavera, María; Marco Contelles, José Luis
  • Publication
    Página web orientada a la evaluación “in silico” de nuevas sustancias con interés biológico. Parte III
    (2020-06-19) Ramos Alonso, Eva; Romero Martínez, Manuel Alejandro; Rodríguez Martín, Abigail; Rodríguez Talavera, María; Marco Contelles, José Luis; García Cantón, Carolina; Pita Pita, Rene
  • Publication
    Página web orientada a la evaluación in silico de nuevas sustancias con interés biológico (parte VI)
    (2023-05) Ramos Alonso, Eva; Marco Contelles, José Luis; Pita Pita, Rene; Rodríguez Martín, Abigail; Rodriguez Talavera, María; Egea, Javier; Paramo Muñoz, Ana; Ríos, Cristóbal de los; Romero Martínez, Manuel Alejandro; García Cantón, Carolina
    En la línea de las ediciones anteriores, los resultados obtenidos con el proyecto "INSILITOX" han sido muy positivos. Por esta razón, el equipo se ha propuesto continuar optimizando la página web añadiendo nuevos recursos que apoyen la formación de los estudiantes, tanto de Grado como de Posgrado, en este entorno multilingüe de aprendizaje virtual adaptativo.
  • Publication
    Página web orientada a la evaluación “in silico” de nuevas sustancias con interés biológico IV
    (2021-05) Ramos Alonso, Eva; Romero Martínez, Manuel Alejandro; García Cantón, Carolina; Marco Contelles, José Luis; Pita Pita, Rene; Rodríguez Martín, Abigail; Rodríguez Talavera, María
  • Publication
    Guía de Prácticas de Laboratorio y seminarios de Toxicología Veterinaria
    (2021) Ramos Alonso, Eva; Del Pino Sans, Javier; Romero Martínez, Manuel Alejandro; Díaz Plaza, María Jesús; Frejo Moya, María Teresa; Moyano-Cires Ivanoff, Paula Viviana
  • Publication
    A History of the Pharmacological Treatment of Bipolar Disorder
    (MDPI, 2018-07-23) López-Muñoz, Francisco; Shen, Winston; D’Ocon, Pilar; Romero Martínez, Manuel Alejandro; Álamo, Cecilio
    In this paper, the authors review the history of the pharmacological treatment of bipolar disorder, from the first nonspecific sedative agents introduced in the 19th and early 20th century, such as solanaceae alkaloids, bromides and barbiturates, to John Cade’s experiments with lithium and the beginning of the so-called “Psychopharmacological Revolution” in the 1950s. We also describe the clinical studies and development processes, enabling the therapeutic introduction of pharmacological agents currently available for the treatment of bipolar disorder in its different phases and manifestations. Those drugs include lithium salts, valproic acid, carbamazepine, new antiepileptic drugs, basically lamotrigine and atypical antipsychotic agents (olanzapine, risperidone, quetiapine, ziprasidone, aripiprazole, asenapine, cariprazine and lurasidone). Finally, the socio-sanitary implications derived from the clinical introduction of these drugs are also discussed.
  • Publication
    Guía de Prácticas de Laboratorio y seminarios de Toxicología de los Alimentos
    (2021) Moyano-Cires Ivanoff, Paula Viviana; Del Pino Sans, Javier; Romero Martínez, Manuel Alejandro; Díaz Plaza, María Jesús; Frejo Moya, María Teresa; Ramos Alonso, Eva
  • Publication
    Toxicology of Blister Agents: Is Melatonin a Potential Therapeutic Option?
    (MDPI, 2021-04-10) Romero Martínez, Manuel Alejandro; Ramos Alonso, Eva; López Muñoz, Francisco; Ríos, Cristóbal de los; Egea, Javier; Gil Martín, Emilio; Pita Pita, Rene; Torrado Durán, Juan José; Serrano López, Dolores Remedios; Juberias, Antonio
    Blister or vesicant chemical warfare agents (CWAs) have been widely used in different military conflicts, including World War I and the Iran-Iraq War. However, their mechanism of action is not fully understood. Sulfur and nitrogen mustard exert toxic effects not only through the alkylation of thiol-bearing macromolecules, such as DNA and proteins, but also produce free radicals that can develop direct toxic effects in target organs such as the eyes, skin, and respiratory system. The lack of effective treatments against vesicant CWAs-induced injury makes us consider, in this complex scenario, the use and development of melatonin-based therapeutic strategies. This multifunctional indoleamine could facilitate neutralization of the oxidative stress, modulate the inflammatory response, and prevent the DNA damage, as well as the long-term health consequences mediated by vesicant CWAs-induced epigenetic mechanisms. In this context, it would be essential to develop new galenic formulations for the use of orally and/or topically applied melatonin for the prophylaxis against vesicant CWAs, as well as the development of post-exposure treatments in the near future.