Person:
López Parra, Ana María

First Name

Ana María

Last Name

López Parra

Affiliation

Universidad Complutense de Madrid

Faculty / Institute

Medicina

Department

Medicina Legal, Psiquiatría y Patología

Area

Medicina Legal y Forense

Identifiers

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Now showing 1 - 9 of 9

Influence of Diet, Menstruation and Genetic Factors on Iron Status: A Cross-Sectional Study in Spanish Women of Childbearing Age
(MDPI, 2014-03-06) Blanco-Rojo, Ruth; Toxqui, Laura; López Parra, Ana María; Baeza Richer, Carlos Ignacio; Pérez-Granados, Ana; Arroyo Pardo, Eduardo; Vaquero, M.
The aim of this study was to investigate the combined influence of diet, menstruation and genetic factors on iron status in Spanish menstruating women (n = 142). Dietary intake was assessed by a 72-h detailed dietary report and menstrual blood loss by a questionnaire, to determine a Menstrual Blood Loss Coefficient (MBLC). Five selected SNPs were genotyped: rs3811647, rs1799852 (Tf gene); rs1375515 (CACNA2D3 gene); and rs1800562 and rs1799945 (HFE gene, mutations C282Y and H63D, respectively). Iron biomarkers were determined and cluster analysis was performed. Differences among clusters in dietary intake, menstrual blood loss parameters and genotype frequencies distribution were studied. A categorical regression was performed to identify factors associated with cluster belonging. Three clusters were identified: women with poor iron status close to developing iron deficiency anemia (Cluster 1, n = 26); women with mild iron deficiency (Cluster 2, n = 59) and women with normal iron status (Cluster 3, n = 57). Three independent factors, red meat consumption, MBLC and mutation C282Y, were included in the model that better explained cluster belonging (R2 = 0.142, p < 0.001). In conclusion, the combination of high red meat consumption, low menstrual blood loss and the HFE C282Y mutation may protect from iron deficiency in women of childbearing age. These findings could be useful to implement adequate strategies to prevent iron deficiency anemia.
Formación de los tutores de las prácticas externas como herramienta eficaz en la mejora del aprendizaje del estudiante y su inserción laboral
(2020-08-31) Delgado Losada, María Luisa; Finker Morgenstern, Lucila; Dorado Pérez, María Dolores; García Redondo, María Lourdes; Montenegro Peña, María Mercedes; López Parra, Ana María; Arroyo Pardo, Eduardo; Ramos Sánchez, Mabel; Schweiger Gallo, Inge; García Blanco, Noelia; De Gregorio Domínguez, Beatriz; Linuesa Ureña, Sara; González Sánchez, Noelia; Luzuriaga González, Izar; Valencia Garrote, José Luis; Méndez Luque, María Dolores; García Domínguez, María Encarnación; Martín Antón, Noelia; Megías Martín, Noelia; Monteagudo Tomico, Luna; Fernández Montealegre, Alicia; Senosiain Carasusan, Ainara; Tabasco González, Estela; Ramírez Sánchez, Marta Inmaculada; García Bernuz, Jessica; Pérez Bret, Encarnación; Gómez de la Peña, Juan Carlos; Güerberof Arenas, Mercedes; Súarez Castro, Miriam; Moreno-Cid Sánchez, Antonio Justo; De la Higuera García, Laura; Dacosta Felpeto, María; Iglesias Castañeda, Leyre; Amarillo Martín, Jeniffer; Rodríguez Rodríguez, Kruz; García González, Alba
El objetivo del proyecto es mejorar la calidad de la tutorización de las prácticas externas y fomentar las buenas prácticas que garanticen el proceso de enseñanza-aprendizaje. Están implicados tutores académicos, externos, instituciones y estudiantes
Association between Neutrophil-to-Lymphocyte Ratio with Abdominal Obesity and Healthy Eating Index in a Representative Older Spanish Population
(MDPI, 2020-03-23) Rodríguez Rodríguez, Elena; López Sobaler, Ana María; Ortega Anta, Rosa María; Delgado Losada, Mª Luisa; López Parra, Ana María; Aparicio Vizuete, Aránzazu
Poor diet quality and obesity, especially abdominal obesity, have been associated with systemic inflammation. The neutrophil-to-lymphocyte Ratio (NLR) is an available and inexpensive inflammation biomarker. The aim of the present study was to determine the association of dietary patterns and obesity with an inflammatory state. A group of 1747 Spanish noninstitutionalized older adults individuals were included, and a food-frequency questionnaire was applied. The Global Food Score (GFS) and Healthy Eating Index for Spanish population (SHEI) were calculated. Weight, height and waist (WC) and hip circumferences were measured, and BMI, waist-to-height ratio (WHtR), and waist-to-hip ratio (WHR) determined. In addition, body-fat percentage was measured by bioimpedance. NLR was calculated (NLR ≥ p80: 2.6; 2.8 and 2.4 as inflammatory status in the entire population, men and women, respectively). The men with inflammatory status presented significative higher values of WC, WHtR, WHR, and body-fat percentage (101.82 ± 10.34 cm, 0.61 ± 0.06, 0.98 ± 0.06, and 31.68 ± 5.94%, respectively) than those with better inflammatory status (100.18 ± 10.22 cm, 0.59 ± 0.06, 0.97 ± 0.07, and 30.31 ± 6.16%, respectively). Those males with worse inflammatory state had lower scores for protein foods (OR = 0.898 (0.812–0.993); p = 0.037). The women with NLR ≥ 2.4 had higher WHtR and WHR (0.62 ± 0.09 and 0.91 ± 0.09) than those with NLR < 2.4 (0.60 ± 0.08 and 0.90 ± 0.08). In multiple linear regression analysis, NLR was positively related with WHtR and negatively related with SHEI score (β = 0.224 ± 0.094; R 2 = 0.060; p < 0.05 and β = −0.218 ± 0.101; R 2 = 0.061; p < 0.05), adjusting by sex, age, marital status, education level, smoking, hours of sleeping and inflammatory diseases. In women, the higher the SHEI and GFS scores were and the better meeting the aims of cereal and vegetable servings, the less the odds of inflammatory status (OR = 0.970 (0.948–0.992); p = 0.008; OR = 0.963 (0.932–0.995); p = 0.024; OR = 0.818 (0.688–0.974); p = 0.024 and OR = 0.829 (0.730–0.942); p = 0.004, respectively). WHtR and quality of diet is related to the inflammation status in older adults regardless to the sex.
Acenocoumarol Pharmacogenetic Dosing Algorithm versus Usual Care in Patients with Venous Thromboembolism: A Randomised Clinical Trial
(MDPI, 2021-06-30) Tong, Hoi Yan; Borobia, Alberto; Quintana Díaz, Manuel; Fabra, Sara; González Viñolis, Manuel; Fernández Capitán, Carmen; Rodriguez Dávila, María; Lorenzo, Alicia; López Parra, Ana María; Ruiz Giménez, Nuria; Abad Santos, Francisco; Suarez, Carmen; Madridano, Olga; Gómez Cerezo, Jorge; Llamas, Pilar; Baeza Richer, Carlos Ignacio; Arroyo Pardo, Eduardo; Carcas, Antonio J.
Patients with venous thromboembolism (VTE) require immediate treatment with anticoagulants such as acenocoumarol. This multicentre randomised clinical trial evaluated the effectiveness of a dosing pharmacogenetic algorithm versus a standard-of-care dose adjustment at the beginning of acenocoumarol treatment. We included 144 patients with VTE. On the day of recruitment, a blood sample was obtained for genotyping (CYP2C9*2, CYP2C9*3, VKORC1, CYP4F2, APOE). Dose adjustment was performed on day 3 or 4 after the start of treatment according to the assigned group and the follow-up was at 12 weeks. The principal variable was the percentage of patients with an international normalised ratio (INR) within the therapeutic range on day 7. Thirty-four (47.2%) patients had an INR within the therapeutic range at day 7 after the start of treatment in the genotype-guided group compared with 14 (21.9%) in the control group (p = 0.0023). There were no significant differences in the time to achieve a stable INR, the number of INRs within the range in the first 6 weeks and at the end of study. Our results suggest the use of a pharmacogenetic algorithm for patients with VTE could be useful in achieving target INR control in the first days of treatment.
Toxinología clínica, alimentaria y ambiental
(Editorial Complutense, 2007) Capó Martí, Miguel Andrés; Anadón Baselga, María José; Uroz Martínez, María Victoria; Nogal Ruiz, María del Mar; López Parra, Ana María
La toxinología es la ciencia que estudia las toxinas. Si tóxico, es toda sustancia venenosa, toxina es aquella sustancia elaborada por un ser vivo, que, además, tiene acción fuera de él, sin que sea necesaria la muerte o descomposición del ser productor, para su liberación ni para su acción"". Según esta definición, y con la novedosa nomenclatura de los cinco reinos de seres vivos (Mónera, Protista, Fungi, Vegetal y Animal), en la que se sustenta este trabajo, se establecen cinco grupos de toxinas: bacterianas, protozoarias, fúngicas, vegetales y animales. En este libro, de gran ayuda tanto al estudiante como al profesional que necesite ampliar conocimientos, se profundiza en los cinco reinos de organismos, así como, y de manera más amplia, en los diferentes grupos de toxinas.
Transparencia en la calidad docente: reflexión solidaria intradepartamental de las evaluaciones obtenidas en las encuestas del estudiantado del programa docentia. Análisis de los factores de mejora
(2023-07-13) Arroyo Pardo, Eduardo; Álvarez Melcón, Ángela; Calero García, María Luz; Belando Montoro, María Remedios; Delgado Losada, María Luisa; González Matilla, Juan Francisco; Hernández Martín, Marta María; López Parra, Ana María; Aguilera Morales, Encarnación; Díaz Ramiro, Eva María; Fuentes Gómez-Calcerrada, Juan Luis; García Molto, Amelia Isabel Martina; González Martín, María Rosario; Hernández Ibáñez, María Del Carmen; Lopes Gomes, Claudia Filipa; López Matayoshi, César Yoshi; López Sánchez, Ramón; Moreno Pimentel, Antonio Gabriel; Palomo Díez, Sara; Prados Atienza, José María; Rebollada Merino, Agustín Miguel; Redondo Corcobado, Paloma; Rodríguez Bertos, Antonio Manuel; Royo Moreno, Fernando María; Rubio Valdehita, Susana; Tabanera De Lucio, Enrique; Martín Freire, Vanesa; Chinchilla Rodríguez, Blanca; Delgado Ramos Lima, Alice Helena; Porras González, Néstor
El objeto del proyecto es realizar una reflexión conjunta de profesores en diferentes departamentos, con el fin de identificar aquellos ítems, planteados por Docentia-UCM, que han arrojado resultados mejorables. Posteriormente serán contrastados con un panel de docentes calificados como “excelentes” (de los que algunos ya forman parte del presente proyecto), en base al programa, con excelencia en una jornada de reflexión, abierta a todos los profesores de cada departamento implicado, y a los delegados de las asignaturas impartidas por dicho departamento. Se busca la mejora de las evaluaciones de los profesores.
De la granja a la comercialización: Una estrategia de integración en Ciencia y Tecnología de los Alimentos (CYTA)
(2022-06-30) Cambero Rodríguez, María Isabel; Isabel Redondo, Beatriz; Pérez Sen, Raquel; Pérez Cabal, María de lo Angeles; Fuente Vázquez, Jesús de la; Olivares Moreno, Álvaro; Fernández Álvarez, Leónides; Arroyo Pardo, Eduardo; Aguado Ramo, Juan Antonio; Aguilar Jaime, María Victoria; Alonso Monge, Rebeca María del Mar; Arias López, Patricia; Blanco Flores, María Dolores; Cabeza Briales, María Concepción; Cabezas Albéniz, Almudena; Calahorra Fernández, Felipe; Cervantes Navarro, Isabel; Orozco Arias, David de; Díaz Díaz Chiron, María Teresa; Díez Romera, Mariano; Fernández Álvarez, Manuela; Ferreira García-Osorio, Andrea; Gamonal Martos, Miriam; García Álvarez, Andrés; García de Fernando Minguillón, Gonzalo Doroteo; González Aguilera, Guillermo; González de Chávarri Echániz, Elisabet; Herranz Hernández, Beatriz; Justo Ruiz, Carolina; López Bote, Clemente; López Parra, Ana María; Martín Amores, Ruth; Mateos Aparicio, Inmaculada; Monteoliva Díaz, Lucía; Orgaz Martín, Belén; Ortiz Vera, Luis Tomás; Radu Selea, Alexandra Andrea; Ramos Cervantes, Ana María; Rebolé Garrigós, Almudena; Rodríguez Fernández, Carmina; Rodríguez Peña, José Manuel; Salazar Hijosa, Raúl; Santos Arnaiz, Carlos; Santos López, Sergio; Sanz Gonzalez, Javier; Torrecilla Velasco, José Santiago; Velasco de Diego, Raquel; Velasco Villar, Susana
Integración de la Granja Docente de Veterinaria en las actividades prácticas del Grado en Ciencia y Tecnología de los Alimentos; creación de una plataforma virtual como herramienta de coordinación de la producción-elaboración y comercialización de productos.
Genealogy: The Tree Where History Meets Genetics
(MDPI, 2021-11-12) Gomes, Cláudia; Palomo Díez, Sara; López Parra, Ana María; Arroyo Pardo, Eduardo
Although biological relationships are a universal reality for all human beings, the concepts of “family” and “family bond” depend on both the geographic region and the historical moment to which they refer. However, the concept of “family” can be determinant in a large variety of societies, since it can influence the lines of succession, inheritances and social relationships, as well as where and with whom an individual is buried. The relation between a deceased person and other members of a community, other individuals of the same necropolis, or even with those who are buried in the same tomb can be analysed from the genetic point of view, considering different perspectives: archaeological, historical, and forensic. In the present work, the concepts of “family” and “kinship” are discussed, explaining the relevance of genetic analysis, such as nuclear and lineage markers, and their contribution to genealogical research, for example in the heritage of surnames and Y-chromosome, as well as those cases where some discrepancies with historical record are detected, such as cases of adoption. Finally, we explain how genetic genealogical analyses can help to solve some cold cases, through the analysis of biologically related relatives.
Genética y geografía estudio de cinco poblaciones de los Pirineos en el contexto de la Península Ibérica para marcadores del cromosoma Y
(Universidad Complutense de Madrid, 2015) López Parra, Ana María; Mesa Santurino, María Soledad; Arroyo Pardo, Eduardo