Person: Andreu Rodríguez, José Manuel
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First Name
José Manuel
Last Name
Andreu Rodríguez
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Psicología
Department
Personalidad, Evaluación y Psicología Clínica
Area
Personalidad, Evaluación y Tratamiento Psicológico
Identifiers
10 results
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Item The structural assembly switch of cell division protein FtsZ probed with fluorescent allosteric inhibitors(Chemical Science, 2017) Artola Pérez de Azanza, Marta Elena; Ruiz Ávila, Laura, Laura B.; Ramírez Aportela, Erney; Fernando Martínez, R.; Araujo Bazán, Lidia; Vázquez Villa, Henar; Martín Fontecha, María del Mar; Oliva Blanco, María Ángela; Martín Galiano, Antonio Javier; Chacón Montes, Pablo; López Rodríguez, María Luz; Andreu Rodríguez, José Manuel; Huecas Gayo, SoniaFtsZ is a widely conserved tubulin-like GTPase that directs bacterial cell division and a new target for antibiotic discovery. This protein assembly machine cooperatively polymerizes forming single-stranded filaments, by means of self-switching between inactive and actively associating monomer conformations. The structural switch mechanism was proposed to involve a movement of the C-terminal and N-terminal FtsZ domains, opening a cleft between them, allosterically coupled to the formation of a tight association interface between consecutive subunits along the filament. The effective antibacterial benzamide PC190723 binds into the open interdomain cleft and stabilizes FtsZ filaments, thus impairing correct formation of the FtsZ ring for cell division. We have designed fluorescent analogs of PC190723 to probe the FtsZ structural assembly switch. Among them, nitrobenzoxadiazole probes specifically bind to assembled FtsZ rather than to monomers. Probes with several spacer lengths between the fluorophore and benzamide moieties suggest a binding site extension along the interdomain cleft. These probes label FtsZ rings of live Bacillus subtilis and Staphylococcus aureus, without apparently modifying normal cell morphology and growth, but at high concentrations they induce impaired bacterial division phenotypes typical of benzamide antibacterials. During the FtsZ assembly-disassembly process, the fluorescence anisotropy of the probes changes upon binding and dissociating from FtsZ, thus reporting open and closed FtsZ interdomain clefts. Our results demonstrate the structural mechanism of the FtsZ assembly switch, and suggest that the probes bind into the open clefts in cellular FtsZ polymers preferably to unassembled FtsZ in the bacterial cytosol.Item Moderate and severe aggression justification in instrumental and reactive contexts(Social Behavior & Personality, 2008) Peña Fernández, María Elena de la; Andreu Rodríguez, José Manuel; Graña Gómez, José Luis; Pahlavan, F.; Ramirez, J. MartinThe main goal of this study was to analyze the justification of interpersonal aggression in various situations or contexts. For this purpose, a self-report instrument was employed that measures different kinds of aggressive behaviors in situations in which it may be considered justified: the Cuestionario de Actitudes Morales sobre Agresión (CAMA; Ramirez, 1991), a reliable and valid test to measure the different degrees to which youth and adolescents may justify interpersonal aggression (Ramirez & Andreu, 2006). A large sample (N = 735) of participants from various educational centers of Madrid was utilized. Results revealed that normative beliefs vary as a function of age, sex, and the instrumental-reactive context. Reactive situations elicited higher levels of justification than instrumental situations and higher levels in the justifying beliefs about severe aggression were found among men than among women and in adolescents than in young adults. There were no significant differences in the justifying beliefs about moderate aggression.Item Un modelo dicotómico de agresión y su evaluación mediante dos autoinformes: el CAMA y el RPQ(Psicopatología Clínica, Legal y Forense, 2006) Andreu Rodríguez, José Manuel; Ramirez, J. Martin; Raine, AdrianEl presente trabajo muestra la complejidad inherente a la clasificación de la agresión, no sólo porque este constructo ya en sí mismo es ambiguo y presenta múltiples facetas y matices, sino porque los investigadores y especialistas en la materia utilizan sus propios conceptos y tipología de la agresión que podrían estar haciendo referencia a la misma realidad epistemológica aunque denominándola de distinta forma. Con esta intención, se describen los principales tipos de agresión que los especialistas en esta disciplina han ido ofreciendo a la comunidad científica a lo largo de las últimas décadas. A partir del reconocimiento de esta complejidad, se ofrece un modelo dicotómico de la agresión basado fundamentalmente en el análisis de la motivación básica del agresor (Raine et al., 2006). Según este enfoque, las diferentes conductas agresivas que se manifiestan en los diferentes focos de expresión, podrían polarizarse en dos estructuras básicas: reactiva y proactiva. Al respecto, se añaden los correlatos psicopato(bio)lógicos que apoyan estas dos dimensiones, así como también la utilidad de su valoración mediante dos auto-informes (CAMA y RPQ) de cara al estudio de la motivación “oculta” del agresor. Finalmente, planteamos la utilidad de este modelo teórico para analizar la motivación del comportamiento agresivo a través de diferentes instrumentos de auto-informe.[ABSTRACT]The present paper shows the inherent complexity of classifying aggression not only because this construct is already ambiguous in itself and presents various dimensions and shades, but also because researchers and specialists in this field use their own concepts and typology of aggression which could make reference to the some epistemological reality but naming it in a different way. With this intention in mind, we describe the different types of aggression that specialists in this field have been offering to the scientific community during the last decades. Starting with the awareness of this complexity, we offer a dichotomic model of aggression fundamentally based on the analysis of the basic motivation of the aggressor. According to this perspective, the aggressive behaviours manifested in the different community settings, could polarize in two basic structures: reactive and proactive. To this, we sum the psychopatho(bio)logical correlates which support these two dimensions, as well as the utility of the self-reports in order to analyse the hidden motivation of the aggressor using two different inventories: (CAMA y RPQ). Finally, we question the usefulness of this theoretical model to shed light on the motivation of aggressive behavior through different self-report instruments.Item Aggression's typologies(International Review of Social Psychology, 2003) Ramirez, J. Martin; Andreu Rodríguez, José ManuelFar from being a term associated with a single type of behavior, aggression is a multifaceted concept, encompassing a multitude of behaviors with different functions and antecedents. Although not all forms of aggression are contemplated in this paper, our purpose is to provide a short summary of much of the research that attempts to distinguish among different kinds of animal and human aggression. We conclude suggesting the need for a new empirical model to be used as a typology of human aggression.[RÉSUMÉ]Loin d’être associée à un type unique de comportement, l’agression correspond davantage à une multitude de comportements avec différentes fonctions et différents antécédents et doit donc être appréhendée comme un concept à facettes multiples. Bien que toutes les formes d’agression ne soient pas envisagées dans cet article , notre propos est d’offrir une brève synthèse permettant de distinguer différents types d’agression animale et humaine. Nous concluons sur l’utilité d’un nouveau modèle empirique permettant une typologie de l’agression humaine.Item The main symptoms of the AHA-syndrome: relationships between anger, hostility, and aggression in a normal population(The AHA-Syndrome and Cardiovascular Diseases, 2009) Ramirez, J. Martin; Andreu Rodríguez, José ManuelThe purpose of the present study is to analyse the relationship between the main symptoms of the AHA-Syndrome – anger, hostility, and aggression – summarising the main empirical results of our research in normal people. The different definitions of aggression may be grouped according to whether the primary goal is distress or harm, focussing primarily on the objective infliction of harm, or on the subjective intention of harming. Most classifications in the literature show two kinds of aggression, even if different names are used: (i) hostile aggression – also known as reactive, impulsive, or affective – is an act, primarily oriented to hurt another individual; and (ii) instrumental aggression – also known as proactive, premeditated, or predative – is a means or tool for solving problems, or for obtaining a variety of objectives. As predicted, there was a positive correlation between the experience and expression of anger. Anger involved physiological arousal and prepared for aggression. Finally, hostility positively correlated with anger and different kinds of aggression, but not its degree of justification.- Project number: 429
Item Elaboración de un sistema de evaluación digital de la calidad docente e inserción laboral del Master Habilitante en Psicología General Sanitaria(2021) Peña Fernández, María Elena; Andreu Rodríguez, José Manuel; Peces-Barba Recio, Vanesa; Gómez Gutierrez, María del MarDiseño y desarrollo de un sistema de evaluación digital que permita la valoración y análisis de la calidad docente del profesorado que imparte docencia en el mismo, así mismo como la evaluación de la calidad de la supervisión y tutorización de los TFM realizada por los profesores y por último evaluar y analizar no sólo la calidad docente de los tutores de prácticas externos, sino también la calidad de los centros de prácticas de los que dispone actualmente el Master. De forma complementaria, se diseñará y desarrollará un sistema de evaluación digital que permita la valoración y análisis de la inserción laboral de nuestros egresados. - Project number: 14
Item Mindfulness aplicado al aula universitaria(2017) Andreu Rodríguez, José Manuel; Peña Fernández, María Elena; Graña Gómez, José Luis; Redondo Rodríguez, Natalia; Cuenca Montesino, María Luisa; Sáez Cutando, CristinaEl Mindfulness, literalmente traducido como atención o conciencia plena, es una de las múltiples formas de meditación que se basa en centrar la mente en el momento presente. En otras palabras, es un estado de conciencia que se desarrolla prestando una atención concreta, sostenida y deliberada sin juzgar las experiencias del aquí y del ahora. La mayoría de los estudios sobre los efectos de la práctica continuada del Mindfulness se han realizado en contextos clínicos y laborales. Se disponen de suficientes resultados que muestran que los beneficios del Mindfulness están relacionados con la salud, el bienestar psicológico, las competencias sociales o el rendimiento académico de niños y adolescentes. Sin embargo, son pocos los estudios que se han llevado a cabo en el contexto educativo universitario y, más específicamente, en relación con estudiantes universitarios. Item The Search for Antibacterial Inhibitors Targeting Cell Division Protein FtsZ at Its Nucleotide and Allosteric Binding Sites.(Biomedicines, 2022) Andreu Rodríguez, José Manuel; Huecas Gayo, Sonia; Araujo Bazán, Lidia; Vázquez Villa, Henar; Martín-Fontecha Corrales, María Del MarThe global spread of bacterial antimicrobial resistance is associated to millions of deaths from bacterial infections per year, many of which were previously treatable. This, combined with slow antibiotic deployment, has created an urgent need for developing new antibiotics. A still clinically unexploited mode of action consists in suppressing bacterial cell division. FtsZ, an assembling GTPase, is the key protein organizing division in most bacteria and an attractive target for antibiotic discovery. Nevertheless, developing effective antibacterial inhibitors targeting FtsZ has proven challenging. Here we review our decade-long multidisciplinary research on small molecule inhibitors of bacterial division, in the context of global efforts to discover FtsZ-targeting antibiotics. We focus on methods to characterize synthetic inhibitors that either replace bound GTP from the FtsZ nucleotide binding pocket conserved across diverse bacteria or selectively bind into the allosteric site at the interdomain cleft of FtsZ from Bacillus subtilis and the pathogen Staphylococcus aureus. These approaches include phenotype screening combined with fluorescence polarization screens for ligands binding into each site, followed by detailed cytological profiling, and biochemical and structural studies. The results are analyzed to design an optimized workflow to identify effective FtsZ inhibitors, and new approaches for the discovery of FtsZ-targeting antibiotics are discussed.Item Recharge estimation of a small karstic aquifer in a semiarid Mediterranean region (southeastern Spain) using a hydrological mode.(Hydrological processes, 2013) Touhami, Issam; Andreu Rodríguez, José Manuel; Chirino, E.; Sánchez Sutil, J. R.; Moutahir, H.; Pulido Bosch, A.; Martínez Santos, Pedro; Bellot, J.Mediterranean aquifers are frequently subject to the joint effect of intensive exploitation and low recharge values. Besides, groundwater is the only available water resource in many Mediterranean regions. Groundwater recharge studies are therefore necessary to underpin water management practices. This manuscript presents a methodology to estimate groundwater recharge in a small limestone aquifer of southeastern Spain. The HYDROBAL model is used to calculate daily soil water balances on the basis of hydrological and soil data as well as on vegetation cover. Deep drainage model outputs are converted into water table variations using a lumped model add‐on. The adjustment between observed and calculated water table levels is in the order of r2 = 0.87. This correlation coefficient suggests that HYDROBAL is a useful tool to estimate groundwater recharge in the region. In addition, differences in groundwater recharge rates are observed for dry, average and wet years. Estimated recharge rates range between 0% and 18% of the mean annual rainfall, which corresponds to a net recharge of 0 to 59 mm year−1. Recharge rates increase proportionally with precipitation (r 2 = 0.90).Item Aggression, and some related psychological constructs (Anger, Hostility, and Impulsivity): comments from a research project(Neuroscience and Biobehavioural Reviews, 2006) Ramirez, J. Martin; Andreu Rodríguez, José ManuelThe purpose of the present study was: first, to offer a few theoretical considerations on the concept of human aggression and its main types; and second, to analyse the relationship between those types of aggression and other related psychological constructs, such as anger, hostility, and impulsivity, summarizing the main empirical results of our research in progress. In order to assess their eventual correlations, several self-report techniques were compared: a) AQ, used to measure several kinds of aggression, anger, and hostility; b) CAMA, a questionnaire already used in a variety of cultures, for measuring attitudes toward interpersonal aggression in different instrumental and hostile situations; c) ASQ, an instrument for measuring experienced anger and its expression in assertive or aggressive ways; and d) BIS, used to prove three impulsiveness sub-traits: motor, attentional, and non-planning impulsiveness. The different definitions of aggression may be grouped according to whether the primary goal is distress or harm, focusing primarily on the objective infliction of harm, or on the subjective intention of harming. Most classifications in the literature show two kinds of aggression, even if different names are used: Hostile Aggression (among other names it is also known as 'reactive, impulsive, or affective') is an act primarily oriented to hurt another individual; and Instrumental Aggression (also known as 'proactive, premeditated, or predative') is a means or tool for solving problems or for obtaining a variety of objectives. As predicted, there was a positive correlation between experience and expression of anger. Anger involved physiological arousal and prepared for aggression. Anger and impulsiveness were also positively correlated with hostile aggression, but not with instrumental aggression. In the case of impulsiveness, non-planning impulsiveness was positively correlated with some situations related to hostile aggression, such as emotional agitation or lack of communication, but not with instrumental one.