Person: Rosales Conrado, Noelia
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First Name
Noelia
Last Name
Rosales Conrado
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Ciencias Químicas
Department
Química Analítica
Area
Química Analítica
Identifiers
37 results
Search Results
Now showing 1 - 10 of 37
Item Determination of phenolic compounds in residual brewing yeast using matrix solid-phase dispersion extraction assisted by titanium dioxide nanoparticles(Journal of Chromatography A, 2019) Gómez Mejía, Esther; Rosales Conrado, Noelia; León González, María Eugenia De; Madrid Albarrán, María Yolanda; ELSEVIERA simple and efficient low-cost matrix solid-phase dispersion (MSPD) extraction based on TiO2nanopar-ticles (NPs) and diatomaceous earth has been developed for the recovery of phenolic compounds fromresidual brewing yeast. Experimental conditions for MSPD extraction were optimized by an experimen-tal design approach. A screening factorial design plus replicates at the center point, followed by surfaceresponse analysis were used. The simultaneous identification and quantification of eleven main nat-ural polyphenols: caffeic, chlorogenic, p-coumaric, 3,4-dihydroxibenzoic, trans-ferulic and gallic acids,kaempferol, myricetin, naringin, quercetin and rutin, was possible by combining MSPD and capillaryliquid chromatography couple to a diode array detection system (cLC-DAD) and liquid chromatogra-phy couple to a triple quadrupole analyzer (LC–MS/MS). Moreover, residual brewing yeast extracts wereevaluated in terms of DPPH (1,1-diphenyl–2 picrylhydrazyl) free radical scavenging activity. Polyphenol-nanoparticle interaction was studied by UV–vis spectroscopy and electron transmission microscopy(TEM), pointing out a stable interplay that assists phenolic isolation. The extracted polyphenol quan-tities were within the 3.2-1,500 g g−1range, and the high antioxidant activity estimated suggested thatdeveloped MSPD is a successful, simple, efficient and rapid method for the extraction and recovery of bioactive phenolic compounds, which promotes the reuse and re-evaluation of brewing yeast agri-foodby-products.Item Extraction of polyphenols and synthesis of new activated carbon from spent coffee grounds(Scientific Reports, 2019) Ramón-Gonçalves, Marina; Alcaraz, Lorena; Pérez-Ferreras, Susana; León González, María Eugenia De; Rosales Conrado, Noelia; López, Félix A.; Nature ResearchA valorization process of spent coffee grounds (SCG) was studied. Thus, a two-stage process, the first stage of polyphenols extraction and synthesis of a carbonaceous precursor and a subsequent stage of obtaining activated carbon (AC) by means of a carbonization process from the precursor of the previous stage, was performed. The extraction was carried out with a hydro-alcoholic solution in a pressure reactor, modifying time, temperature and different mixtures EtOH:H2O. To optimize the polyphenols extraction, a two-level factorial experimental design with three replicates at the central point was used. The best results were obtained by using a temperature of 80 °C during 30 min with a mixture of EtOH:H2O 50:50 (v/v). Caffeine and chlorogenic acid were the most abundant compounds in the analysed extracts, ranging from 0.09 to 4.8 mg∙g−1 and 0.06 to 9.7 mg∙g−1, respectively. Similarly, an experimental design was realized in order to analyze the influence of different variables in the AC obtained process (reaction time, temperature and KOH:precursor ratio). The best results were 1 h, 850 °C, and a mixture of 2.5:1. The obtained activated carbons exhibit a great specific surface (between 1600 m2∙g−1 and 2330 m2∙g−1) with a microporous surface. Finally, the adsorption capacity of the activated carbons was evaluated by methylene blue adsorption.Item Learning Principal Component Analysis by Using Data from Air Quality Networks(Journal of Chemical Education, 2017) Pérez Arribas, Luis Vicente; León González, María Eugenia; Rosales Conrado, NoeliaWith the final objective of using computational and chemometrics tools in the chemistry studies, this paper shows the methodology and interpretation of the Principal Component Analysis (PCA) using pollution data from different cities. This paper describes how students can obtain data on air quality and process such data for additional information related to the pollution sources, climate effects, and social aspects over pollution levels by using a powerful chemometrics tool such as principal component analysis (PCA). The paper could also be useful for students interested in environmental chemistry and pollution interpretation; this statistical method is a simple way to display visually as much as possible of the total variation of the data in a few dimensions, and it is an excellent tool for looking into the normal pollution patterns.- Project number: 81
Item Página web del grupo bilingüe de la Facultad de Educación para la enseñanza de las ciencias: elaboración, explotación y juicio crítico de los estudiantes de cara a la internacionalización de la docencia(2017) Peña Martínez, Juan; Sánchez Gómez, Pedro; Rosales Conrado, Noelia; Fresno Galán, María; Acebrón Hernández, Ainhoa; Merino Catalina, Beatriz; Cabezas Martínez, Sara; Meléndez Pérez, Celia; Martínez Arevalo, Victoria; Lazaro Sánchez, PaulaElaboración de una página web con material didáctico de Ciencias para el grupo bilingüe de Educación, que además sirve para ofrecer información para estudiantes que pudieran estar interesados en formar parte del grupo, incluyendo estudiantes extranjeros. Item Unravelling the in vitro and in vivo potential of selenium nanoparticles in Alzheimer’s disease: A bioanalytical review(Talanta, 2023) Vicente Zurdo, David; Rosales Conrado, Noelia; León González, María Eugenia DeAlzheimer’s disease (AD) is a devastating neurodegenerative disorder characterized by progressive cognitive decline and the accumulation of beta-amyloid plaques and tau tangles in the brain. Current therapies have limited efficacy, prompting the search for novel treatments. Selenium nanoparticles (SeNPs) have emerged as promising candidates for AD therapy due to their unique physicochemical properties and potential therapeutic effects. This review provides an overview of SeNPs and their potential application in AD treatment, as well as the main bioanalytical techniques applied in this field. SeNPs possess antioxidant and anti-inflammatory properties, making them potential candidates to combat the oxidative stress and neuroinflammation associated with AD. Moreover, SeNPs have shown the ability to cross the blood-brain barrier (BBB), allowing them to target brain regions affected by AD pathology. Various methods for synthesizing SeNPs are explored, including chemical,physical and biological synthesis approaches. Based on the employment of algae, yeast, fungi, and plants, green methods offer a promising and biocompatible alternative for SeNPs production. In vitro studies have demonstrated the potential of SeNPs in reducing beta-amyloid aggregation and inhibiting tau hyperphosphorylation, providing evidence of their neuroprotective effects on neuronal cells. In vivo studies using transgenic mousem models and AD-induced symptoms have shown promising results, with SeNPs treatment leading to cognitive improvements and reduced amyloid plaque burden in the hippocampus. Looking ahead, future trends in SeNPs research involve developing innovative brain delivery strategies to enhance their therapeutic potential, exploring alternative animal models to complement traditional mouse studies, and investigating multi-targeted SeNPs formulations to address multiple aspects of AD pathology. Overall, SeNPs represent a promising avenue for AD treatment, and further research in this field may pave the way for effective and much-needed therapeutic interventions for individuals affected by this debilitating disease.Item Valorization of prunus seed oils: fatty acids composition and oxidative stability(Molecules, 2023) Rodríguez-Blázquez, Sandra; Gómez Mejía, Esther; Rosales Conrado, Noelia; León González, María Eugenia De; García-Sánchez, Beatriz; Miranda Carreño, RubénPrunus fruit seeds are one of the main types of agri-food waste generated worldwide during the processing of fruits to produce jams, juices and preserves. To valorize this by-product, the aim of this work was the nutritional analysis of peach, apricot, plum and cherry seeds using the official AOAC methods, together with the extraction and characterization of the lipid profile of seed oils using GC-FID, as well as the measurement of the antioxidant activity and oxidative stability using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) free-radical scavenging method. Chemometric tools were required for data evaluation and the obtained results indicated that the main component of seeds were oils (30–38%, w). All seed oils were rich in oleic (C18:1n9c) and linoleic (C18:2n6c) acids and presented heart-healthy lipid indexes. Oil antioxidant activity was estimated in the range IC50 = 20–35 mg·mL−1, and high oxidative stability was observed for all evaluated oils during 1–22 storage days, with the plum seed oil being the most antioxidant and stable over time. Oxidative stability was also positively correlated with oleic acid content and negatively correlated with linoleic acid content. Therefore, this research showed that the four Prunus seed oils present interesting healthy characteristics for their use and potential application in the cosmetic and nutraceutical industries.Item Neuroprotective Action of Multitarget 7-Aminophenanthridin-6(5H)-one Derivatives against Metal-Induced Cell Death and Oxidative Stress in SN56 Cells(ACS Chemical Neuroscience, 2021) Moyano-Cires Ivanoff, Paula Viviana; Vicente Zurdo, David; Blázquez-Barbadillo, Cristina; Menéndez Ramos, José Carlos; González Matilla, Juan Francisco; Rosales Conrado, Noelia; Pino Sans, Javier DelNeurodegenerative diseases have been associated with brain metal accumulation, which produces oxidative stress (OS), matrix metalloproteinases (MMPs) induction, and neuronal cell death. Several metals have been reported to downregulate both the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway and the antioxidant enzymes regulated by it, mediating OS induction and neurodegeneration. Among a recently discovered family of multitarget 7-amino-phenanthridin-6-one derivatives (APH) the most promising compounds were tested against metal-induced cell death and OS in SN56 cells. These compounds, designed to have chelating activity, are known to inhibit some MMPs and to present antioxidant and neuroprotective effects against hydrogen peroxide treatment to SN56 neuronal cells. However, the mechanisms that mediate this protective effect are not fully understood. The obtained results show that compounds APH1, APH2, APH3, APH4, and APH5 were only able to chelate iron and copper ions among all metals studied and that APH3, APH4, and APH5 were also able to chelate mercury ion. However, none of them was able to chelate zinc, cadmium, and aluminum, thus exhibiting selective chelating activity that can be partly responsible for their neuroprotective action. Otherwise, our results indicate that their antioxidant effect is mediated through induction of the Nrf2 pathway that leads to overexpression of antioxidant enzymes. Finally, these compounds exhibited neuroprotective effects, reversing partially or completely the cytotoxic effects induced by the metals studied depending on the compound used. APH4 was the most effective and safe compound.- Project number: 47
Item Integración de los enfoques AICLE y CTIM en las actividades experimentales del grupo bilingüe de la Facultad de Educación(2019) Peña Martínez, Juan; Rosales Conrado, Noelia; Sánchez Gómez, Pedro; García Núñez, Iván; Herrero Ojalvo, Ignacio GilbertoEn el presente proyecto se han rediseñado las prácticas de Física del grupo bilingüe para que los estudiantes apliquen el doble enfoque Ciencia-Tecnología-Ingeniería-Matemáticas (CTIM) y Aprendizaje Integrado de Ciencias en Lengua Extranjera (AICLE). Asimismo, se ha recabado su valoración para futuros trabajos. - Project number: 186
Item Las ciencias están en las noticias() Peña Martínez, Juan; Hebrero Domínguez, Gema; Rosales Conrado, Noelia; Gonzalo Llera, Carolina; Li, Minghui; Ortiz Iniesta, María Jesús; Moraleda Ruano, Álvaro; Ester Mariñoso, Pilar; Zuluaga Arévalo, J. Alexandra; Vázquez Parra, Jorge AntonioEste proyecto describe una propuesta didáctica orientada a la enseñanza de la ciencia a través del uso de noticias de los medios de comunicación. El objetivo principal es mejorar la comprensión de los estudiantes sobre conceptos científicos al mismo tiempo que fomenta un enfoque crítico y responsable hacia los temas que se tratan en dichas noticias. Al incorporar ejemplos del mundo real y eventos actuales, el proyecto busca involucrar a los estudiantes y promover una comprensión más profunda de los temas científicos. Item Adding sustainability in analytical chemistry education through monitoring aquarium water quality(Sustainable Chemistry, 2023) Rosales Conrado, Noelia; Peña Martínez, JuanThis paper introduces a captivating topic for upper-level analytical chemistry capstone projects, focusing on aquarium water analysis. This provides a more comprehensive understanding of the role of analytical chemistry towards sustainability and its environmental, economic, societal and education dimensions. Regarding the crucial role of maintaining optimal aquarium water quality for the welfare of aquatic life, students are tasked with envisioning and executing the measurement of key parameters, including pH, ammonium, nitrite, and nitrate contents. This hands-on experience not only engages students in real-world applications, but also allows them to delve into essential analytical chemistry principles. They carefully select measurement methods, considering factors such as instrument availability, ease of use, precision and sensitivity requirements, sample size, and matrix effects. Besides fostering the acquisition of technical and soft skills, one notable aspect of this type of project is the exceptionally high student satisfaction. Furthermore, the project’s outcomes have proven to be significant predictors of learning achievements. Additionally, it lays the foundation for exploring potential designs of aquaponics systems and fosters interdisciplinary projects, expanding the practical applications in the field of chemistry education. Overall, these projects exemplify enriching and engaging educational experiences that empower students with valuable skills and knowledge while encouraging them to explore novel avenues in analytical chemistry.