Person:
Fragio Arnold, Cristina

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First Name
Cristina
Last Name
Fragio Arnold
URI
https://hdl.handle.net/20.500.14352/80406
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Veterinaria
Department
Medicina y Cirugía Animal
Area
Medicina y Cirugía Animal
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    Urinary Tamm-Horsfall protein excretion is a potential early biomarker of renal distal tubular damage in canine leishmaniosis
    (Veterinary Parasitology, 2024) Daza, María A.; Miró Corrales, Guadalupe; Fragio Arnold, Cristina; Pérez Montero, Blanca; Belinchón Esteban, Sheila; Fermín Rodríguez, María Luisa
    This study evaluates distal tubular damage in early stages of renal disease in dogs with naturally acquired leishmaniosis. Pherograms of urinary proteins separated in vertical electrophoresis system (SDS-PAGE) were evaluated. Peptide fingerprint and fragmentation (MALDI-TOF TOF) identified bands located at 100 and 60 kDa as Tamm-Horsfall protein (THP) and albumin, respectively. The variables examined were: urine protein to creatinine ratio (UPC), total number of bands, quantification of THP urinary excretion through the optical density (OD %) of bands located at 100 kDa, blood creatinine, and urine specific gravity (USG). Positive correlation was found between UPC and the number of bands (ρ = 0.75849, P = <0.0001). Negative correlation was identified between UPC and OD % of 100 kDa bands (ρ = −0.85332, P = <0.0001), and the number of bands and OD % of 100 kDa bands (ρ = −0.74479, P = <0.0001). The area under the ROC curve was 0.991 (95 % CI, 0.976–1). The optimal cut-off UPC that better discriminated between urines with high or low OD% of THP was 0.46 with 92.6 % sensitivity and 96.2 % specificity. Our findings indicate that non azotemic dogs with borderline proteinuria might excrete low amount of THP, which could suggest tubular damage in early stages of chronic kidney disease.
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    Síndrome Nefrótico secundario a Leptospirosis
    (2007) Fragio Arnold, Cristina; Daza González, María Ángeles; Rupérez Noguer, María Cristina; Martin, M.; Toni Delgado, Paloma; García Pérez, Enrique
    Un caso clínico de Leptospirosis canina con sintomatología neurológica aguda de tipo convulsivo
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    Bases moleculares de la activacion plaquetaria en el perro
    (2002) Fragio Arnold, Cristina; Moreno Martínez, Francisco; Toni Delgado, Paloma
    Se ha estudiado la participacion del metabolismo de polifosfoinositidos y de los segundos mensajeros derivados de este ultimo en la secrecion de serotonina inducida por agonistas fisiologicos y afisiologicos en plaquetas caninas. Asimismo, se ha abordado el estudio de las vias de liberacion de acido araquidonico, asi como la implicacion de este acido graso y de sus metabolitos en la secrecion plaquetaria. Tambie se ha investigado la existencia de proteinas-G-reguladoras en plaquetas caninas y su posible participacion en la secrecion. Los resultados de este trabajo demuestran la participacion de la hidrolisis de polifosfoinositidos en la secrecion inducida por trombina, evidenciando no obstante, la existencia de vias de activacion alternativas independientes del metabolismo de fosfoinositidos y estimulantes por calcio y/o proteinas-G. Los ..