Person:
Giné Domínguez, Elena

First Name

Elena

Last Name

Giné Domínguez

Affiliation

Universidad Complutense de Madrid

Faculty / Institute

Medicina

Department

Biología Celular

Area

Biología Celular

Identifiers

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Now showing 1 - 10 of 13

Desarrollo e implementación de una herramienta de evaluación en los tribunales de los Trabajos de Fin de Grado y Fin de Máster en las ciencias de la salud
(2016) Sanz Miguel, María del Carmen; Giné Domínguez, Elena; Navas Hernández, Ángeles; Hurtado Carneiro, Verónica; Benito Miguel, Marta; Gutiérrez Nogués, Ángel; Dongil Sánchez, Pilar; Pérez García, Ana
Classic psychedelics and alcohol use disorders: A systematic review of human and animal studies
(Wiley, 2022-08-31) Calleja Conde, Javier; Morales García, Jose Angel; Echeverry Alzate, Víctor; Bühler, Kora Mareen; Giné Domínguez, Elena; López Moreno, José Antonio
Classic psychedelics refer to substances such as lysergic acid diethylamide (LSD), psilocybin, ayahuasca, and mescaline, which induce altered states of consciousness by acting mainly on 5-HT2A receptors. Recently, the interest of psychedelics as pharmacological treatment for psychiatric disorders has increased significantly, including their use on problematic use of alcohol. This systematic review is aimed to analyse the last two decades of studies examining the relationship between classic psychedelics and alcohol consumption. We searched PubMed and PsycInfo for human and preclinical studies published between January 2000 to December 2021. The search identified 639 publications. After selection, 27 studies were included. Human studies (n = 20) generally show promising data and seem to indicate that classic psychedelics could help reduce alcohol consumption. Nevertheless, some of these studies present methodological concerns such as low number of participants, lack of control group or difficulty in determining the effect of classic psychedelics in isolation. On the other hand, preclinical studies (n = 7) investigating the effect of these compounds on voluntary alcohol consumption are scarce and show some conflicting data. Among these compounds, psilocybin seems to show the most consistent data indicating that this compound could be a potential candidate to treat alcohol use disorders. In the absence of understanding the biological and/or psychological mechanisms, more studies including methodological quality parameters are needed to finally determine the effects of classic psychedelics on alcohol consumption.
I Olimpiadas de Histología UCM. Aplicación del aprendizaje basado en juegos en el conocimiento de la Histología en el grado en Medicina
(2023-07-27) Martínez Mora, Mª del Carmen; Cuesta Rubio, Natalia; Sanz Miguel, Mª del Carmen; Morales García, José Ángel; Giné Domínguez, Elena; Gómez del Moral Martín Consuegra, Manuel; Cortegano Jimeno, María Isabel; López Moreno, José Antonio; Buhler, Kora Mareen Katharina; López Gómez, Ana; Jiménez Canales, Francisco Javier; Calleja Conde, Javier; Echeverry Alzate, Víctor Alfonso; Grijota Martínez, Mª Carmen
El presente proyecto ha desarrollado una actividad de aprendizaje basado en juegos (Olimpiada de Histología) para asentar los contenidos de Histología Humana en el grado en Medicina, mediante una experiencia de aprendizaje activo divertida y motivadora.
Competencias en comunicación médica: un arma para desmontar bulos en neurociencia
(2021-06) Morales García, Jose Angel; Blázquez Díez, Cristina; Crespo Rivas, Gonzalo; González García, David; Puente Sainz, Marta; Jiménez Canales, Francisco Javier; Cortegano Jimeno, Maria Isabel; Giné Domínguez, Elena; Gómez del Moral Martín-Consuegra, Manuel María; Hurtado Carneiro, Verónica; López Moreno, José Antonio; Martínez Mora, María del Carmen; Pérez Martínez, David Andrés; Sanz Miguel, María del Carmen
Este proyecto se diseñó con el objetivo general de favorecer la mejora en las capacidades comunicativas de los alumnos del grado en Medicina. De esta manera fomentamos que, en su futura actividad profesional, sean capaces de transmitir conocimientos y expresar argumentos de una manera clara y sencilla, pero con rigor, sabiéndose adaptar a las características concretas de cada situación y sobre todo del tipo de audiencia. Conseguimos así, una mejora en la comunicación científico-médica con compañeros de profesión, pero también en la comunicación con pacientes y sus familiares, usando un lenguaje más coloquial. En este contexto de comunicación, quisimos además proporcionar la información y herramientas necesarias para que nuestros alumnos puedan ir desarrollando habilidades que les permitan luchar contra los bulos en cuestiones de salud y más específicamente dentro del campo de la neurociencia. De esta manera, además de fomentar sus competencias transversales en comunicación, luchamos contra la neurofobia, puesto que incentivamos la pérdida del miedo a la terminología específica de las disciplinas relacionadas con el sistema nervioso, fomentando su dotes y habilidades comunicativas para expresarse también en términos divulgativos.
Histone Deacetylase Gene Expression Following Binge Alcohol Consumption in Rats and Humans
(Wiley, 2015-10) López Moreno, José Antonio; Marcos, Miguel; Calleja Conde, Javier; Echeverry-Alzate, Victor; Buhler, Kora M.; Costa-Alba, Pilar; Bernardo, Edgar; Laso, Francisco Javier; Rodríguez de Fonseca, Fernando; Nadal, Rose; Viveros, María Paz; Maldonado, Rafael; Giné Domínguez, Elena
Background: Alcohol binge drinking is one of the most common patterns of excessive alcohol use and recent data would suggest that histone deacetylases (HDACs) gene expression profiling could be useful as a biomarker for psychiatric disorders. Methods: This study aimed to characterize the gene expression patterns of Hdac 1–11 in samples of rat peripheral blood, liver, heart, prefrontal cortex, and amygdala following repeated binge alcohol consumption and to determine the parallelism of Hdac gene expression between rats and humans in peripheral blood. To accomplish this goal, we examined Hdac gene expression following 1, 4, or 8 alcohol binges (3 g/kg, orally) in the rat, in patients who were admitted to the hospital emergency department for acute alcohol intoxication, and in rats trained in daily operant alcohol self-administration. Results: We primarily found that acute alcohol binging reduced gene expression (Hdac1–10) in the peripheral blood of alcohol-na€ıve rats and that this effect was attenuated following repeated alcohol binges. There was also a reduction of Hdac gene expression in the liver (Hdac2,4,5), whereas there was increased expression in the heart (Hdac1,7,8) and amygdala (Hdac1,2,5). Additionally, increased blood alcohol concentrations were measured in rat blood at 1 to 4 hours following repeated alcohol binging, and the only group that developed hepatic steotosis (fatty liver) were those animals exposed to 8 alcohol binge events. Finally, both binge consumption of alcohol in humans and daily operant alcohol self-administration in rats increased Hdac gene expression in peripheral blood. Conclusions: Our results suggest that increases in HDAC gene expression within the peripheral blood are associated with chronic alcohol consumption, whereas HDAC gene expression is reduced following initial exposure to alcohol.
C/EBP regulates TFAM expression, mitochondrial function and autophagy in cellular models of Parkinson’s Disease
(MDPI, 2023-01-11) Sierra Magro, Ana; Giné Domínguez, Elena; Morales García, José Ángel; Bartolome, Fernando; Lozano Muñoz, David; Alarcón Gil, Jesús; Sanz Sancristobal, Marina; Alonso Gil, Sandra; Cortes Canteli, Marta; Carro, Eva; Perez Castillo, Ana
La enfermedad de Parkinson (EP) es un trastorno neurodegenerativo que resulta de la degeneración de las neuronas dopaminérgicas de la sustancia negra pars compacta (SNpc). Dado que sólo se dispone de tratamientos sintomáticos, se necesitan nuevas dianas celulares y moleculares implicadas en el inicio y la progresión de esta enfermedad para desarrollar tratamientos eficaces. Los niveles del factor de transcripción CCAAT/Enhancer Binding Protein β (C/EBPβ) están alterados en pacientes con diversas enfermedades neurodegenerativas, lo que sugiere que puede ser una buena diana terapéutica para el tratamiento de la EP. Mediante la combinación de datos genéticos in silico se generó una lista de genes implicados en la EP que pueden ser regulados por C/EBPβ, entre los que se encuentra el factor de transcripción mitocondrial A (TFAM). En este trabajo, observamos que la sobreexpresión de C/EBPβ aumentaba la actividad promotora de TFAM. Sin embargo, la regulación a la baja de C/EBPβ en diferentes modelos celulares de EP/neuroinflamación produjo un aumento de los niveles de TFAM, junto con otros marcadores mitocondriales. Esto nos llevó a proponer una acumulación de mitocondrias no funcionales posiblemente debido a la alteración de su degradación autofágica en ausencia de C/EBPβ. Entonces, concluimos que C/EBPβ no sólo está involucrado en procesos dañinos que ocurren en la EP, como la inflamación, sino que también está implicado en la función mitocondrial y la autofagia en condiciones similares a la EP.
The genetics of self-reported trait impulsivity: Contribution of catecholaminergic gene variants in European ancestry individuals
(Elsevier, 2022-09-18) Bühler, Kora Mareen; Rincón Pérez, Irene; Calleja Conde, Javier; Albert, Jacobo; Hinojosa Poveda, José Antonio; Giné Domínguez, Elena; Echeverry lzate, Víctor; López Moreno, José Antonio; Huertas Rodríguez, Evelio
Increased trait impulsivity is a core element in several mental disorders. Given the durable and consistent nature of trait impulsivity, studies have explored its relation to stable biological measures. Variation in catecholaminergic neurotransmission by genetic variants could be one of these biological substrates. Here, 905 participants of European-ancestry completed the Barratt Impulsiveness Scale–11 and were genotyped in three single nucleotide polymorphisms related to catecholaminergic neurotransmission: the DRD2/ ANKK Taq1A, the C957T DRD2 and the Val158Met of the COMT gene. We found significant main effects of Val158Met and C957T on BIS-11 score. Also, interactions with gender were significant in both SNPs with a tendency to slightly different genotype and allele associations with the BIStotal score between male and female participants. Whereas in females, higher impulsivity scores were obtained by participants with the Val158Met heterozygous genotype (Met/Val), data indicate a trend towards a higher impulsivity score in male Val-allele carriers. In the case of C957T, only a tentative association between male Tallele carriers and higher impulsivity scores in comparison to CC genotype carriers could be established. No significant associations were found between BIS-11 and Taq1A. We provide further evidence for a gender-specific implication of Val158Met and C957T in trait impulsivity.
The Women Neuroscientists in the Cajal School
(Frontiers, 2019-07) Sanz, Carmen; Nombela; Cristina; Castro San Miguel, Fernando De; Giné Domínguez, Elena; Martínez Mora, María Del Carmen
At the beginning of the 20th century, in view of the growing international recognition of Santiago Ramón y Cajal, the Spanish authorities took some important steps to support Cajal’s scientific work. This recognition peaked in 1906, when Camillo Golgi and Santiago Ramón y Cajal shared the Nobel Prize in Physiology or Medicine. The Spanish government provided Cajal a state-of-the-art laboratory in Madrid to allow him to continue with his research and they funded salaries to pay his first tenured collaborators, the number of which increased further after the creation of the Junta para Ampliación de Estudios (JAE). The JAE was an organism set up to help promising researchers develop their careers in different ways, thereby contributing to the development of science in Spain. Although largely forgotten or relatively unknown, there has been a recent revival in the recognition of the school that developed around Cajal, collectively referred to as the Spanish Neurological School (or colloquially, as the Cajal School or School of Madrid). Almost all Cajal’s collaborators were men, although a limited number of female scientists spent part of their careers at the heart of the Cajal School. Here we discuss these women and their work in the laboratory in Madrid. We have tracked the careers of Laura Forster (from Australia/United Kingdom), Manuela Serra, María Soledad Ruiz-Capillas and María Luisa Herreros (all Spanish), through their scientific publications, both in the journal founded by Cajal and elsewhere, and from other documentary sources. To complete the picture, we also outline the careers of other secondary figures that contributed to the production and running of Cajal’s laboratory in Madrid. We show here that the dawn of Spanish neuroscience included a number of contributions from female researchers who to date, have received little recognition.
Differential effects of environmental enrichment and isolation housing on the hormonal and neurochemical responses to stress in the prefrontal cortex of the adult rat: relationship to working and emotional memories.
(Springer Verlag, 2013) Garrido, Pedro; Blas, Marta de; Ronzoni Blázquez, Giacomo; Cordero, Isabel; Antón, María; Giné Domínguez, Elena; Santos Montes, Ángel; Arco González, Alberto del; Segovia Camargo, Gregorio; Mora Teruel, Francisco
The present study was designed to investigate the modulation of the stress responses by the environmental conditions and its putative neurobiological mechanisms. For that an integrative study on the effects of environmental enrichment and isolation housing on (1) the corticosterone, dopamine and acetylcholine responses to acute restraint stress in the prefrontal cortex (PFC) of the awake rat; (2) the mRNA levels of glucocorticoid receptors (GRs) in the PFC, and (3) the behavioral responses to stress, related to the PFC (habituation to a novel environment, spatial-working memory and inhibitory avoidance response) was performed. Male Wistar rats were maintained from 3 to 6 months of age in two different conditions: enriched (EC) or impoverished (IC). Animals were stereotaxically implanted with bilateral guide cannulae in the PFC to perform microdialysis experiments to evaluate the concentrations of corticosterone, dopamine and acetylcholine. EC animals showed lower increases of corticosterone and dopamine but not of acetylcholine than IC animals in the PFC in response to acute restraint stress (20 min). In the PFC, GR mRNA levels showed a trend towards an enhancement in EC animals. EC reduced the days to learn the spatial working memory task (radial-water maze). Spatial working memory, however, was not different between groups in either basal or stress conditions. Inhibitory avoidance response was reduced in EC rats. The changes produced by EC in the neurochemical, neuroendocrine and behavioral parameters evaluated suggest that EC rats could show a better coping during an acute stress challenge.
Santiago Ramón y Cajal: un modelo de excelencia para desarrollar competencias en el Grado en Medicina
(2018-06-30) Martínez Mora, María del Carmen; Giné Domínguez, Elena; Sanz Miguel, María del Carmen; Varas Fajardo, Alberto; Pérez Martínez, David Andrés; Valiño Seoane, Iria; Martínez Murillo, Ricardo; De Castro Soubriet, Fernando
El presente proyecto ha acercado la figura de Santiago Ramón y Cajal a los estudiantes de Medicina como estrategia para el desarrollo de competencias generales, específicas y transversales necesarias para la formación de profesionales competentes. Se han realizado una serie de actividades en torno a nuestro Premio Nobel que han involucrado a docentes, investigadores y clínicos.