Metastatic outgrowth via the two-way interplay of autophagy and metabolism
| dc.contributor.author | Barzegar Behrooz, Amir | |
| dc.contributor.author | Cordani, Marco | |
| dc.contributor.author | Donadelli, Massimo | |
| dc.contributor.author | Ghavami, Saeid | |
| dc.date.accessioned | 2024-02-01T13:41:40Z | |
| dc.date.available | 2024-02-01T13:41:40Z | |
| dc.date.issued | 2023 | |
| dc.description.abstract | Metastasis represents one of the most dangerous issue of cancer progression, characterized by intricate interactions between invading tumor cells, various proteins, and other cells on the way towards target sites. Tumor cells, while undergoing metastasis, engage in dynamic dialogues with stromal cells and undertake epithelial-mesenchymal transition (EMT) phenoconversion. To ensure survival, tumor cells employ several strategies such as restructuring their metabolic needs to adapt to the alterations of the microenvironmental resources via different mechanisms including macroautophagy (autophagy) and to circumvent anoikis—a form of cell death induced upon detachment from the extracellular matrix (ECM). This review focuses on the puzzling connections of autophagy and energetic metabolism within the context of cancer metastasis. | |
| dc.description.department | Depto. de Bioquímica y Biología Molecular | |
| dc.description.faculty | Fac. de Ciencias Biológicas | |
| dc.description.refereed | TRUE | |
| dc.description.sponsorship | Ministerio de Ciencia e Innovación (España) | |
| dc.description.sponsorship | University of Manitoba | |
| dc.description.sponsorship | European Commission | |
| dc.description.sponsorship | Ministry of Health (Italy) | |
| dc.description.sponsorship | CancerCare Manitoba Foundation | |
| dc.description.status | inpress | |
| dc.identifier.citation | Amir Barzegar Behrooz, Marco Cordani, Massimo Donadelli, Saeid Ghavami, Metastatic outgrowth via the two-way interplay of autophagy and metabolism, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2023, 166824, ISSN 0925-4439, https://doi.org/10.1016/j.bbadis.2023.166824. | |
| dc.identifier.doi | 10.1016/j.bbadis.2023.166824 | |
| dc.identifier.essn | 1879-260X | |
| dc.identifier.issn | 0925-4439 | |
| dc.identifier.officialurl | https://doi.org/10.1016/j.bbadis.2023.166824 | |
| dc.identifier.relatedurl | https://www.sciencedirect.com/science/article/abs/pii/S0925443923001904?via%3Dihub | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14352/97772 | |
| dc.journal.title | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | |
| dc.language.iso | eng | |
| dc.publisher | Elsevier | |
| dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | en |
| dc.rights.accessRights | restricted access | |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
| dc.subject.keyword | Cancer | |
| dc.subject.keyword | Autophagy | |
| dc.subject.keyword | Metastasis | |
| dc.subject.ucm | Bioquímica (Biología) | |
| dc.subject.ucm | Biología celular (Biología) | |
| dc.subject.unesco | 2407 Biología Celular | |
| dc.subject.unesco | 2415 Biología Molecular | |
| dc.title | Metastatic outgrowth via the two-way interplay of autophagy and metabolism | |
| dc.type | journal article | |
| dc.type.hasVersion | VoR | |
| dspace.entity.type | Publication | |
| relation.isAuthorOfPublication | f61da389-972a-4336-8e1f-f3fe854c9c9f | |
| relation.isAuthorOfPublication.latestForDiscovery | f61da389-972a-4336-8e1f-f3fe854c9c9f |
Download
Original bundle
1 - 1 of 1