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The Lymphatic Headmaster of the Mast Cell-Related Splanchnic Inflammation in Portal Hypertension

dc.contributor.authorAller Reyero, María De Los-Ángeles
dc.contributor.authorBlanco-Rivero, Javier
dc.contributor.authorArias, Natalia
dc.contributor.authorSantamaria, Luis
dc.contributor.authorArias Pérez, Jaime
dc.date.accessioned2023-06-17T12:35:21Z
dc.date.available2023-06-17T12:35:21Z
dc.date.issued2019-06-29
dc.description.abstractPortal hypertension is a common complication of liver disease, either acute or chronic. Consequently, in chronic liver disease, such as the hypertensive mesenteric venous pathology, the coexisting inflammatory response is classically characterized by the splanchnic blood circulation. However, a vascular lymphatic pathology is produced simultaneously with the splanchnic arterio-venous impairments. The pathological increase of the mesenteric venous pressure, by mechanotransduction of the venous endothelium hyperpressure, causes an inflammatory response involving the subendothelial mast cells and the lymphatic endothelium of the intestinal villi lacteal. In portal hypertension, the intestinal lymphatic inflammatory response through the development of mesenteric-systemic lymphatic collateral vessels favors the systemic diffusion of substances with a molecular pattern associated with damage and pathogens of intestinal origin. When the chronic hepatic insufficiency worsens the portal hypertensive inflammatory response, the splanchnic lymphatic system transports the hyperplasied intestinal mast cells to the mesenteric lymphatic complex. Then, an acquired immune response regulating a new hepato-intestinal metabolic scenario is activated. Therefore, reduction of the hepatic metabolism would reduce its key centralized functions, such as the metabolic, detoxifying and antioxidant functions which would try to be substituted by their peroxisome activity, among other functions of the mast cells.
dc.description.departmentDepto. de Cirugía
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Ciencia e Innovación (MICINN)
dc.description.sponsorshipMinisterio de Economía y Competitividad (MINECO)
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/65744
dc.identifier.doi10.3390/cells8070658
dc.identifier.issn2073-4409
dc.identifier.officialurlhttps://doi.org/10.3390/cells8070658
dc.identifier.relatedurlhttps://www.mdpi.com/2073-4409/8/7/658
dc.identifier.urihttps://hdl.handle.net/20.500.14352/12564
dc.issue.number7
dc.journal.titleCells
dc.language.isoeng
dc.page.initial658
dc.publisherMDPI
dc.relation.projectIDPSI2017-83893-R
dc.relation.projectIDPSI2015-73111-EXP y PSI2017-90806-REDT
dc.rightsAtribución 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/es/
dc.subject.keywordlymphatics
dc.subject.keywordmast cells
dc.subject.keywordperoxisomes
dc.subject.keywordportal hypertension
dc.subject.ucmGastroenterología y hepatología
dc.subject.unesco3205.03 Gastroenterología
dc.titleThe Lymphatic Headmaster of the Mast Cell-Related Splanchnic Inflammation in Portal Hypertension
dc.typejournal article
dc.volume.number8
dspace.entity.typePublication
relation.isAuthorOfPublication85e5e561-884d-4dd9-836b-a96635f4e4ae
relation.isAuthorOfPublication6ff8c6f1-c697-4b5f-bc62-61ea606d4969
relation.isAuthorOfPublication.latestForDiscovery6ff8c6f1-c697-4b5f-bc62-61ea606d4969

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