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Detection of telomerase activity in human carcinomas using a trap-ELISA method: correlation with hTR and hTERT expression.

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dc.contributor.authorGonzález-Quevedo, Rosa
dc.contributor.authorMassa, Maria Jose
dc.contributor.authorP Iniesta
dc.contributor.authorJuan Chocano, María Del Carmen De
dc.contributor.authorSánchez Pernaute, Andrés
dc.contributor.authorTorres García, Antonio José
dc.contributor.authorBalibrea Cantero, José Luis
dc.contributor.authorBenito De Las Heras, Manuel R.
dc.contributor.authorIniesta Serrano, María Pilar
dc.date.accessioned2025-01-27T11:50:33Z
dc.date.available2025-01-27T11:50:33Z
dc.date.issued2000-03-01
dc.description.abstractWe have evaluated telomerase activity in a tumour population of 65 human cancers by using a TRAP-based method, in which detection is performed by an enzyme immunoassay (ELISA). We have corroborated that sensitivity and specificity of this new procedure can be considered similar to that of classical TRAP method, having the advantage of a rapid and reproducible analysis of large pools of samples. Thus, telomerase activity was detected in 83% of the rumours included in our population. Moreover, we found a significant association between enzyme activity and both hTR and hTERT expression (P=0.004 and P=0.04, respectively).
dc.description.departmentDepto. de Cirugía
dc.description.departmentDepto. de Bioquímica y Biología Molecular
dc.description.facultyFac. de Medicina
dc.description.facultyFac. de Farmacia
dc.description.refereedTRUE
dc.description.statuspub
dc.identifier.citationGonzález-Quevedo R, de Juan C, Massa MJ, Sánchez-Pernaute A, Torres A, Balibrea JL, Benito M, Iniesta P. Detection of telomerase activity in human carcinomas using a trap-ELISA method: correlation with hTR and hTERT expression. Int J Oncol. 2000 Mar;16(3):623-8. doi: 10.3892/ijo.16.3.623. PMID: 10675498.
dc.identifier.doi10.3892/ijo.16.3.623
dc.identifier.essn1791-2423
dc.identifier.issn1019-6439
dc.identifier.officialurlhttps://doi.org/10.3892/ijo.16.3.623
dc.identifier.relatedurlhttps://www.spandidos-publications.com/ijo
dc.identifier.relatedurlhttps://pubmed.ncbi.nlm.nih.gov/10675498/
dc.identifier.urihttps://hdl.handle.net/20.500.14352/116259
dc.issue.number3
dc.journal.titleINTERNATIONAL JOURNAL OF ONCOLOGY
dc.language.isoeng
dc.page.final628
dc.page.initial623
dc.publisherSPANDIDOS PUBL LTD
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsrestricted access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.cdu615.277.3
dc.subject.ucmCiencias Biomédicas
dc.subject.unesco32 Ciencias Médicas
dc.titleDetection of telomerase activity in human carcinomas using a trap-ELISA method: correlation with hTR and hTERT expression.
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number16
dspace.entity.typePublication
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