Publication:
Estradiol synthesis within the human brain

dc.contributor.authorAzcoitia Elías, Iñigo
dc.contributor.authorYagüe, J. G.
dc.contributor.authorGarcía Segura, Luis Miguel
dc.date.accessioned2023-06-20T03:33:01Z
dc.date.available2023-06-20T03:33:01Z
dc.date.issued2011-09
dc.description.abstractEstradiol biosynthesis is catalyzed by the enzyme aromatase, the product of the CYP19A1 gene. Aromatase is expressed in the brain, where it is involved not only in the control of neuroendocrine events and reproduction, but also in the regulation of neural development, synaptic plasticity and cell survival. In this review we summarize the existing data related with the detection of aromatase in human brain, with particular emphasis in the so-called “non-primary reproductive” areas. Besides hypothalamus, amygdala and preoptic/septal areas, aromatase is expressed in certain regions of basal forebrain, cerebral cortex, hippocampus, thalamus, cerebellum and brainstem of the human brain. Aromatase in human brain is produced by neurons, but there is also an astrocyte subpopulation that constitutively expresses the enzyme. The use of different methodological approaches, including the in vivo analysis by positron emission tomography of human subjects, has permitted to draw a general map of human brain aromatase, but the detailed distribution map is still far to be completed. On the other hand, despite the fact that there is only one aromatase protein, there are multiple mRNA transcripts that differ in the 5'-untranslated region, where regulatory elements reside. To date, some of the aromatase transcripts characteristic of cerebral cortex, as well as of human cell lines of neural origin, have been identified. This characteristic may confer tissue or even region-specific regulation of the expression and therefore it is conceivable to develop selective aromatase modulators to regulate the expression of the enzyme in the human brain
dc.description.departmentDepto. de Biología Celular
dc.description.facultyFac. de Ciencias Biológicas
dc.description.refereedTRUE
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/21571
dc.identifier.doi10.1016/j.neuroscience.2011.02.012
dc.identifier.issn0306-4522
dc.identifier.officialurlhttp://www.sciencedirect.com/science/article/pii/S0306452211001539
dc.identifier.relatedurlhttp://www.journals.elsevier.com/neuroscience
dc.identifier.urihttps://hdl.handle.net/20.500.14352/43835
dc.issue.numberSpecia
dc.journal.titleNeuroscience
dc.language.isoeng
dc.page.final147
dc.page.initial139
dc.publisherElsevier
dc.rights.accessRightsopen access
dc.subject.cdu577.17
dc.subject.cdu612.8
dc.subject.keywordAromatase
dc.subject.keywordEstrogen receptors
dc.subject.keywordEstrogens
dc.subject.keywordHuman brain
dc.subject.keywordLocal estradiol synthesis
dc.subject.ucmNeurociencias (Biológicas)
dc.subject.ucmBioquímica (Biología)
dc.subject.unesco2490 Neurociencias
dc.subject.unesco2302 Bioquímica
dc.titleEstradiol synthesis within the human brain
dc.typejournal article
dc.volume.number191
dspace.entity.typePublication
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