Diruthenium complexes as pH-responsive delivery systems: a quantitative assessment

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dc.contributor.authorColoma Manjón-Cabeza, Isabel
dc.contributor.authorCortijo Montes, Miguel
dc.contributor.authorMancheño Real, María José
dc.contributor.authorLeón González, María Eugenia De
dc.contributor.authorGutierrez, Crisanto
dc.contributor.authorDesvoyes, Bénédicte
dc.contributor.authorHerrero Domínguez, Santiago
dc.contributor.editorROYAL SOCIETY OF CHEMISTRY
dc.date.accessioned2024-01-12T11:22:20Z
dc.date.available2024-01-12T11:22:20Z
dc.date.issued2023
dc.description.abstractThe controlled release of biologically active species from diruthenium compounds is crucial for the development of selective drug delivery systems based on such complexes, which in addition display antineoplastic properties by themselves. In the present work, we analyse in detail the kinetics of the pH-triggered release of the auxin-related hormones 2,4-D (2,4-dichlorophenoxyacetate) and NAA (1-naphthaleneacetate) from the metal–metal bonded tris(formamidinato) Ru25+ complexes [Ru2Cl(μ-DPhF)3(μ-2,4-D)](Ru2,4-D), [Ru2Cl(μ-DPhF)3(μ-NAA)] (RuNAA), [Ru2Cl(μ-DAniF)3(μ-2,4-D)] (Ru’2,4-D) and [Ru2Cl(μ-DAniF)3(μ-NAA)] (Ru’NAA) (DPhF = N,N’-diphenylformamidinate, DAniF = N,N’-bis(p-methoxy)phenylformamidinate). Moreover, the synthesis and complete characterisation of [Ru2Cl(μ-DAniF)3(μ-IAA)] (Ru’IAA, IAA = indole-3-acetate), Ru’2,4-D and Ru’NAA, including the crystal structure of the two latter ones, is reported. The release of auxins is studied through a fluorimetric quantitative assay, which allows determining the influence of different formamidinate ancillary ligands and the nature of the outgoing auxin ligand in the release process. Chemometrics is employed to evaluate the statistical significance of the variables. The release of auxins is slower at physiological pH and occurs faster at slightly acidic pH values. Compounds containing DPhF ancillary ligands and NAA outgoing ligand present a slower dissociation of the auxin, which is not complete in the first 24 h. The release rate is also correlated with the bond distance O1(auxin)–Ru1(hexacoordinated). A mechanism of the substitution reaction is tentatively proposed based on these findings. Overall, these results pave the way towards new systems for the controlled delivery of antineoplastic drugs under mild-acidic conditions like those surrounding solid tumours.
dc.description.departmentDepto. de Química Analítica
dc.description.facultyFac. de Ciencias Químicas
dc.description.refereedTRUE
dc.description.sponsorshipComunidad de Madrid
dc.description.sponsorshipMinisterio de Ciencia e Innovación (España)
dc.description.sponsorshipUniversidad Complutense de Madrid
dc.description.statuspub
dc.identifier.citationColoma, I; Cortijo, M; Mancheño, MJ; León-González, ME; Gutierrez, C; Desvoyes, B; Herrero, S, Diruthenium complexes as pH-responsive delivery systems: a quantitative assessment. 2023, 10(15):4402
dc.identifier.doi10.1039/d3qi00399j
dc.identifier.issn2052-1553
dc.identifier.officialurlhttps://doi.org/10.1039/d3qi00399j
dc.identifier.urihttps://hdl.handle.net/20.500.14352/92750
dc.issue.number15
dc.journal.titleInorganic Chemistry Frontiers
dc.language.isoeng
dc.page.initial4402
dc.publisherRoyal Society of Chemistry
dc.relation.projectIDB2017/ BMD-3770-CM
dc.relation.projectIDRTI2018-094793-B-I00
dc.relation.projectIDCT82/20-CT83/20
dc.rights.accessRightsopen access
dc.subject.cdu543
dc.subject.ucmQuímica analítica (Química)
dc.subject.unesco2301 Química Analítica
dc.titleDiruthenium complexes as pH-responsive delivery systems: a quantitative assessment
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number10
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscoverya10f3452-00da-4212-922b-76f48b7b8dbf
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