Neuroplasticity and inflammatory alterations in the nucleus accumbens are corrected after risperidone treatment in a schizophrenia-related developmental model in rats

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dc.contributor.authorTendilla Beltrán, Hiram
dc.contributor.authorCoatl Cuaya, Heriberto
dc.contributor.authorMeneses Prado, Silvia
dc.contributor.authorVázquez Roque, Ruben Antonio
dc.contributor.authorBrambila, Eduardo
dc.contributor.authorTapia Rodríguez, Miguel
dc.contributor.authorMartín Hernández, David
dc.contributor.authorGarcés Ramírez, Linda
dc.contributor.authorMuñoz Madrigal, José Luis
dc.contributor.authorLeza Cerro, Juan Carlos
dc.contributor.authorFlores, Gonzalo
dc.date.accessioned2023-06-16T14:18:22Z
dc.date.available2023-06-16T14:18:22Z
dc.date.issued2021-07-20
dc.descriptionCRUE-CSIC (Acuerdos Transformativos 2021)
dc.description.abstractIncreased dopaminergic activity in the striatum underlies the neurobiology of psychotic symptoms in schizophrenia (SZ). Beyond the impaired connectivity among the limbic system, the excess of dopamine could lead to inflammation and oxidative/nitrosative stress. It has been suggested that atypical antipsychotic drugs attenuate psychosis not only due to their modulatory activity on the dopaminergic/serotonergic neurotransmission but also due to their anti-inflammatory/antioxidant effects. In such a manner, we assessed the effects of the atypical antipsychotic risperidone (RISP) on the structural neuroplasticity and biochemistry of the striatum in adult rats with neonatal ventral hippocampus lesion (NVHL), which is a developmental SZ-related model. RISP administration (0.25 mg/kg, i.p.) ameliorated the neuronal atrophy and the impairments in the morphology of the dendritic spines in the spiny projection neurons (SPNs) of the ventral striatum (nucleus accumbens: NAcc) in the NVHL rats. Also, RISP treatment normalized the pro-inflammatory pathways and induced the antioxidant activity of the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) in this model. Our results point to the neurotrophic, antiinflammatory, and antioxidant effects of RISP, together with its canonical antipsychotic mechanism, to enhance striatum function in animals with NVHL.
dc.description.departmentDepto. de Farmacología y Toxicología
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Economía y Competitividad (MINECO)/FEDER
dc.description.sponsorshipCONACYT
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/69361
dc.identifier.doi10.1016/j.schres.2021.07.014
dc.identifier.issn0920-9964, ESSN: 1573-2509
dc.identifier.officialurlhttps://doi.org/10.1016/j.schres.2021.07.014
dc.identifier.urihttps://hdl.handle.net/20.500.14352/4605
dc.journal.titleSchizophrenia Research
dc.language.isoeng
dc.page.final28
dc.page.initial17
dc.publisherElsevier
dc.relation.projectIDSAF2016-75500-R
dc.relation.projectIDCONACYT (252808)
dc.rightsAtribución 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/es/
dc.subject.keywordAtypical antipsychotics
dc.subject.keywordSpiny projection neurons
dc.subject.keywordStereology
dc.subject.keywordMAP kinases
dc.subject.keywordNrf2
dc.subject.keywordSmad
dc.subject.ucmFarmacología (Medicina)
dc.subject.ucmNeurociencias (Medicina)
dc.subject.unesco2490 Neurociencias
dc.titleNeuroplasticity and inflammatory alterations in the nucleus accumbens are corrected after risperidone treatment in a schizophrenia-related developmental model in rats
dc.typejournal article
dc.volume.number235
dspace.entity.typePublication
relation.isAuthorOfPublication6af34e23-e137-4fbd-9119-e470b9b2b600
relation.isAuthorOfPublication60ff0835-366b-4a2b-9c1e-4533824ea881
relation.isAuthorOfPublication.latestForDiscovery6af34e23-e137-4fbd-9119-e470b9b2b600
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