The role of dinucleoside polyphosphates on the ocular surface and other eye structures

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dc.contributor.authorCarracedo Rodríguez, Juan Gonzalo
dc.contributor.authorCrooke Álvarez, Almudena
dc.contributor.authorGuzmán Aránguez, Ana Isabel
dc.contributor.authorPintor Just, Jesús Jerónimo
dc.dateReceived 28 February 2016; Accepted 5 July 2016; Corrected proof available online (31/08/2016)
dc.date.accessioned2023-06-18T06:55:24Z
dc.date.available2023-06-18T06:55:24Z
dc.date.issued2016-07-14
dc.description.abstractDinucleoside polyphosphates comprises a group of dinucleotides formed by two nucleosides linked by a variable number of phosphates, abbreviated NpnN (where n represents the number of phosphates). These compounds are naturally occurring substances present in tears, aqueous humour and in the retina. As the consequence of their presence, these dinucleotides contribute to many ocular physiological processes. On the ocular surface, dinucleoside polyphosphates can stimulate tear secretion, mucin release from goblet cells and they help epithelial wound healing by accelerating cell migration rate. These dinucleotides can also stimulate the presence of proteins known to protect the ocular surface against microorganisms, such as lysozyme and lactoferrin. One of the latest discoveries is the ability of some dinucleotides to facilitate the paracellular way on the cornea, therefore allowing the delivery of compounds, such as antiglaucomatous ones, more easily within the eye. The compound Ap4A has been described being abnormally elevated in patient's tears suffering of dry eye, Sjogren syndrome, congenital aniridia, or after refractive surgery, suggesting this molecule as biomarker for dry eye condition. At the intraocular level, some diadenosine polyphosphates are abnormally elevated in glaucoma patients, and this can be related to the stimulation of a P2Y2 receptor that increases the chloride efflux and water movement in the ciliary epithelium. In the retina, the dinucleotide dCp4U, has been proven to be useful to help in the recovery of retinal detachments. Altogether, dinucleoside polyphosphates are a group of compounds which present relevant physiological actions but which also can perform promising therapeutic benefits.en
dc.description.departmentDepto. de Optometría y Visión
dc.description.departmentUnidad Docente de Bioquímica y Biología Molecular
dc.description.facultyFac. de Óptica y Optometría
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Ciencia, Innovación y Universidades (España)
dc.description.sponsorshipRedes Temáticas de Investigación Cooperativa en Salud
dc.description.statusinpress
dc.eprint.idhttps://eprints.ucm.es/id/eprint/38960
dc.identifier.citationCarracedo Rodríguez, G., Crooke Álvarez, A., Guzmán Aranguez, A. M. et al. «The Role of Dinucleoside Polyphosphates on the Ocular Surface and Other Eye Structures». Progress in Retinal and Eye Research, vol. 55, noviembre de 2016, pp. 182-205. DOI.org (Crossref), https://doi.org/10.1016/j.preteyeres.2016.07.001.
dc.identifier.doi10.1016/j.preteyeres.2016.07.001
dc.identifier.issn1350-9462
dc.identifier.officialurlhttp://doi.org/10.1016/j.preteyeres.2016.07.001
dc.identifier.relatedurlhttp://www.sciencedirect.com/science/article/pii/S1350946216300453
dc.identifier.urihttps://hdl.handle.net/20.500.14352/24591
dc.journal.titleProgress in Retinal and Eye Research
dc.language.isoeng
dc.publisherElsevier
dc.relation.projectIDSAF2010-16024
dc.relation.projectIDSAF2013-44416-R
dc.relation.projectIDRD12/0034/0003
dc.rightsAtribución-NoComercial 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by-nc/3.0/es/
dc.subject.cdu577.15
dc.subject.keywordDinucleotides
dc.subject.keywordPurinergic receptors
dc.subject.keywordDiadenosine tetraphosphate
dc.subject.keywordDiquafosol
dc.subject.ucmBioquímica (Química)
dc.subject.ucmOftalmología
dc.subject.ucmGenética
dc.subject.unesco3201.09 Oftalmología
dc.subject.unesco2409 Genética
dc.titleThe role of dinucleoside polyphosphates on the ocular surface and other eye structuresen
dc.typejournal article
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscovery97433353-d31b-4cf5-b2c0-47d2e6703fe5
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