Analysis of the presence of cell proliferation-related molecules in the Tgf-β3 null mutant mouse palate reveals misexpression of EGF and Msx-1

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dc.contributor.authorDel Río, A
dc.contributor.authorLópez-Gordillo, Y
dc.contributor.authorMartínez, M L
dc.contributor.authorBarrio Asensio, María Del Carmen
dc.contributor.authorMurillo Arroyo, Francisco Javier
dc.contributor.authorMaldonado Bautista, Estela
dc.contributor.authorMartínez Sanz, Elena
dc.contributor.authorMartínez Álvarez, María Concepción
dc.date.accessioned2024-02-14T17:17:59Z
dc.date.available2024-02-14T17:17:59Z
dc.date.issued2011
dc.description.abstractThe Tgf-β3 null mutant mouse palate presents several cellular anomalies that lead to the appearance of cleft palate. One of them concerns the cell proliferation of both the palatal medial edge epithelium and mesenchyme. In this work, our aim was to determine whether there was any variation in the presence/distribution of several cell proliferation-related molecules that could be responsible for the cell proliferation defects observed in these palates. Our results showed no difference in the presence of EGF-R, PDGF-A, TGF-β2, Bmp-2, and Bmp-4, and differences were minimal for FGF-10 and Shh. However, the expression of EGF and Msx-1 changed substantially. The shift of the EGF protein expression was the one that most correlated with that of cell proliferation. This molecule is regulated by TGF-β3, and experiments blocking its activity in culture suggest that EGF misexpression in the Tgf-β3 null mutant mouse palate plays a role in the cell proliferation defect observed.
dc.description.departmentDepto. de Anatomía y Embriología
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Sanidad de España
dc.description.sponsorshipComunidad Autónoma de Madrid
dc.description.sponsorshipUniversidad Complutense con Banco Santander
dc.description.statuspub
dc.identifier.citationDel Rio, A., Barrio, M. C., Murillo, J., Maldonado, E., Lopez-Gordillo, Y., Martínez-Sanz, E., ... & Martinez-Alvarez, C. (2011). Analysis of the presence of cell proliferation-related molecules in the Tgf-β3 null mutant mouse palate reveals misexpression of EGF and Msx-1. Cells Tissues Organs, 193(3), 135-150.
dc.identifier.doi10.1159/000319970
dc.identifier.issn1422-6405
dc.identifier.officialurlhttps://karger.com/cto/article/193/3/135/91146/Analysis-of-the-Presence-of-Cell-Proliferation
dc.identifier.urihttps://hdl.handle.net/20.500.14352/101443
dc.issue.number3
dc.journal.titleCells Tissues Organs
dc.language.isoeng
dc.page.final150
dc.page.initial135
dc.publisherKARGER
dc.relation.projectIDinfo:eu-repo/grantAgreement/MICINN//PS09%2F01762/ES/LA FISURA PALATINA: AVANCES EN EL CONOCIMIENTO DE SU PATOGENIA Y ESTUDIO DE LA APLICACION DE UN TRATAMIENTO ALTERNATIVO A LA PALATOPLASTIA EN PERROS FISURADOS/
dc.relation.projectIDPI06/0184
dc.relation.projectIDCCG07-ECM/BIO-2592
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.cdu611.013
dc.subject.cdu611
dc.subject.keywordTgf beta3 Knockout
dc.subject.keywordPalate
dc.subject.keywordEpidermal growth factor
dc.subject.keywordMsx-1
dc.subject.ucmCiencias Biomédicas
dc.subject.unesco32 Ciencias Médicas
dc.subject.unesco24 Ciencias de la Vida
dc.titleAnalysis of the presence of cell proliferation-related molecules in the Tgf-β3 null mutant mouse palate reveals misexpression of EGF and Msx-1
dc.typejournal article
dc.type.hasVersionAM
dc.volume.number193
dspace.entity.typePublication
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