Mast cell-mediated splanchnic cholestatic inflammation

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dc.contributor.authorAller, María Ángeles
dc.contributor.authorMartínez, Vicente
dc.contributor.authorArias, Ana
dc.contributor.authorNava, María Paz
dc.contributor.authorCuervas-Mons, Valentín
dc.contributor.authorVergara, Patri
dc.contributor.authorArias, Jaime
dc.date.accessioned2023-06-17T13:29:23Z
dc.date.available2023-06-17T13:29:23Z
dc.date.issued2019-03-08
dc.description.abstractIntroduction Splanchnic mast cells increase in chronic liver and in acute-on-chronic liver diseases. We administered Ketotifen, a mast cell stabilizer, and measured the mast cells in the splanchnic organs of cholestatic rats. Material and Methods These groups were studied: sham-operated rats (S; n = 15), untreated microsurgical cholestasic rats (C; n = 20) and rats treated with Ketotifen: early (SK-e; n = 20 and CKe; n = 18), and late (SK-l; n = 15 and CK-l; n = 14). Results The cholestatic rats showed systemic and splanchnic impairments, such as ascites, portal hypertension, and biliary proliferation and fibrosis. The rats also showed a splanchnic increase of TNF-α, IL-1β and MCP-1, and a reduction of IL-4, IL-10 and antioxidants. An increase of VEGF in the ileum and mesenteric lymphatic complex was associated with a liver reduction of TGF-β1. Ketotifen reduces the degree of hepatic insufficiency and the splanchnic inflammatory mediators, as well as VEGF and TGF-ß1 levels. Ketotifen also reduces the connective tissue mast cells in the mesenteric lymphatic complex of cholestatic rats, while increases the hepatic mucosal mast cells. Conclusions In cholestatic rats, Ketotifen improves liver function and ascites, and also reduces pro-inflammatory mediators in the splanchnic area. The decrease in connective tissue mast cells in the mesenteric lymphatic complex due to the administration of Ketotifen would lead to the improvement of the inflammatory splanchnic response, and consequently the abovementioned complications.
dc.description.departmentDepto. de Genética, Fisiología y Microbiología
dc.description.facultyFac. de Ciencias Biológicas
dc.description.refereedTRUE
dc.description.sponsorshipMutua Madrileña Automovilista
dc.description.statusinpress
dc.eprint.idhttps://eprints.ucm.es/id/eprint/57125
dc.identifier.doi10.1016/j.clinre.2019.02.001
dc.identifier.issn2210-741X
dc.identifier.officialurlhttps://www.sciencedirect.com/science/article/pii/S2210740119300385?via%3Dihub#!
dc.identifier.urihttps://hdl.handle.net/20.500.14352/13608
dc.journal.titleClinics and Research in Hepatology and Gastroenterology
dc.language.isoeng
dc.page.final14
dc.page.initial1
dc.publisherElsevier
dc.relation.projectID(AP6977/2009)
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subject.cdu576:611.36
dc.subject.keywordCholestasis
dc.subject.keywordMast cells
dc.subject.keywordPortal hypertension
dc.subject.keywordAscites
dc.subject.ucmGastroenterología y hepatología
dc.subject.ucmBiología celular (Biología)
dc.subject.unesco3205.03 Gastroenterología
dc.subject.unesco2407 Biología Celular
dc.titleMast cell-mediated splanchnic cholestatic inflammation
dc.typejournal article
dspace.entity.typePublication
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