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BMP Signalling at the Crossroad of Liver Fibrosis and Regeneration

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dc.contributor.authorHerrera González, Blanca
dc.contributor.authorAddante, Annalisa
dc.contributor.authorSánchez Muñoz, Aránzazu
dc.date.accessioned2023-06-18T00:04:12Z
dc.date.available2023-06-18T00:04:12Z
dc.date.issued2017-12-23
dc.description.abstractBone Morphogenetic Proteins (BMPs) belong to the Transforming Growth Factor-β (TGF-β) family. Initially identified due to their ability to induce bone formation, they are now known to have multiple functions in a variety of tissues, being critical not only during development for tissue morphogenesis and organogenesis but also during adult tissue homeostasis. This review focus on the liver as a target tissue for BMPs actions, devoting most efforts to summarize our knowledge on their recently recognized and/or emerging roles on regulation of the liver regenerative response to various insults, either acute or chronic and their effects on development and progression of liver fibrosis in different pathological conditions. In an attempt to provide the basis for guiding research efforts in this field both the more solid and more controversial areas of research were highlighted.
dc.description.departmentSección Deptal. de Bioquímica y Biología Molecular (Farmacia)
dc.description.facultyFac. de Farmacia
dc.description.refereedTRUE
dc.description.sponsorshipUnión Europea. FP7
dc.description.sponsorshipMinisterio de Economía y Competitividad (MINECO)
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/67119
dc.identifier.doi10.3390/ijms19010039
dc.identifier.issn1422-0067
dc.identifier.officialurlhttps://doi.org/10.3390/ijms19010039
dc.identifier.relatedurlhttps://www.mdpi.com/1422-0067/19/1/39
dc.identifier.urihttps://hdl.handle.net/20.500.14352/19210
dc.issue.number1
dc.journal.titleInternational Journal of Molecular Sciences
dc.language.isoeng
dc.page.initial39
dc.publisherMDPI
dc.relation.projectIDIT-LIVER (316549)
dc.relation.projectIDSAF2015-69145-R
dc.rightsAtribución 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/es/
dc.subject.keywordBMP
dc.subject.keywordliver
dc.subject.keywordfibrosis
dc.subject.keywordregeneration
dc.subject.keywordTGF-β
dc.subject.keywordchronic liver disease
dc.subject.ucmBiología molecular (Farmacia)
dc.subject.ucmBioquímica (Farmacia)
dc.titleBMP Signalling at the Crossroad of Liver Fibrosis and Regeneration
dc.typejournal article
dc.volume.number19
dspace.entity.typePublication
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