Thermoresponsive Polymeric Nanolenses Magnify the Thermal Sensitivity of Single Upconverting Nanoparticles

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dc.contributor.authorLu, Dasheng
dc.contributor.authorRubio Retama, Jorge
dc.contributor.authorMarin, Riccardo
dc.contributor.authorMarqués Ponce, Manuel Ignacio
dc.contributor.authorGómez Calderón, Óscar
dc.contributor.authorMelle Hernández, Sonia
dc.contributor.authorHaro González, Patricia
dc.contributor.authorJaque García, Daniel
dc.date.accessioned2023-06-22T12:54:46Z
dc.date.available2023-06-22T12:54:46Z
dc.date.issued2022-07-30
dc.description© 2022 The Authors. Small published by Wiley-VCH GmbH
dc.description.abstractLanthanide-based upconverting nanoparticles (UCNPs) are trustworthy workhorses in luminescent nanothermometry. The use of UCNPs-based nanothermometers has enabled the determination of the thermal properties of cell membranes and monitoring of in vivo thermal therapies in real time. However, UCNPs boast low thermal sensitivity and brightness, which, along with the difficulty in controlling individual UCNP remotely, make them less than ideal nanothermometers at the single-particle level. In this work, it is shown how these problems can be elegantly solved using a thermoresponsive polymeric coating. Upon decorating the surface of NaYF4 :Er3+ ,Yb3+ UCNPs with poly(N-isopropylacrylamide) (PNIPAM), a >10-fold enhancement in optical forces is observed, allowing stable trapping and manipulation of a single UCNP in the physiological temperature range (20-45 °C). This optical force improvement is accompanied by a significant enhancement of the thermal sensitivity- a maximum value of 8% °C+1 at 32 °C induced by the collapse of PNIPAM. Numerical simulations reveal that the enhancement in thermal sensitivity mainly stems from the high-refractive-index polymeric coating that behaves as a nanolens of high numerical aperture. The results in this work demonstrate how UCNP nanothermometers can be further improved by an adequate surface decoration and open a new avenue toward highly sensitive single-particle nanothermometry.
dc.description.departmentSección Deptal. de Óptica (Óptica)
dc.description.facultyFac. de Óptica y Optometría
dc.description.refereedTRUE
dc.description.sponsorshipMinisterio de Ciencia e Innovación de España
dc.description.sponsorshipComunidad de Madrid (España)
dc.description.sponsorshipCarl Tiggers Foundation (Estocolmo)
dc.description.sponsorshipUniversidad Autónoma de Madrid (España)
dc.description.sponsorshipChina Scholarship Council
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/77749
dc.identifier.doi10.1002/smll.202202452
dc.identifier.issn1613-6810
dc.identifier.officialurlhttps://doi.org/10.1002/smll.202202452
dc.identifier.relatedurlhttps://onlinelibrary.wiley.com/doi/full/10.1002/smll.202202452
dc.identifier.urihttps://hdl.handle.net/20.500.14352/73319
dc.issue.number34
dc.journal.titleSmall
dc.language.isoeng
dc.page.final11 p.
dc.page.initialart.2202452
dc.publisherWiley
dc.relation.projectIDPID2019-106211RB-I00
dc.relation.projectIDS2017/BMD-3867 RENIM-CM
dc.relation.projectIDCTS18:229
dc.relation.projectIDCEX2018-000805-M
dc.relation.projectIDPGC2018-095777-B-C22
dc.relation.projectIDSI1/PJI/2019-00052
dc.relation.projectIDPID2019-105195RA-I00
dc.relation.projectIDMAT2017- 83111R
dc.relation.projectIDPR38/21-36 ANTICIPA-CM
dc.relation.projectID201808350097
dc.rightsAtribución 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/es/
dc.subject.cdu539.2:620.1
dc.subject.cdu535.37
dc.subject.keywordluminescent nanothermometry
dc.subject.keywordoptical force
dc.subject.keywordoptical trapping
dc.subject.keywordpoly(N-isopropylacrylamide)
dc.subject.keywordsurface modification
dc.subject.keywordthermal sensitivity
dc.subject.keywordupconverting nanoparticles.
dc.subject.ucmFísica de materiales
dc.subject.ucmÓptica (Física)
dc.subject.ucmÓptica física, óptica cuántica
dc.subject.unesco2209.19 Óptica Física
dc.subject.unesco2209.19 Óptica física
dc.titleThermoresponsive Polymeric Nanolenses Magnify the Thermal Sensitivity of Single Upconverting Nanoparticles
dc.typejournal article
dc.volume.number18
dspace.entity.typePublication
relation.isAuthorOfPublicatione3951eb6-c03f-4cc1-b643-8450fedd1f67
relation.isAuthorOfPublication6080119e-4199-4330-a163-3f58a24a1160
relation.isAuthorOfPublication.latestForDiscoverye3951eb6-c03f-4cc1-b643-8450fedd1f67
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