Efficacy of antimalarials in oral lichen planus: a systematic review

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dc.contributor.authorTillero, Rosana
dc.contributor.authorGonzález Serrano, José
dc.contributor.authorAlberto Caponio, Vito Carlo
dc.contributor.authorSerrano Valle, Julia
dc.contributor.authorHernández Vallejo, Gonzalo
dc.contributor.authorLópez-Pintor Muñoz, Rosa María
dc.date.accessioned2024-06-11T07:51:40Z
dc.date.available2024-06-11T07:51:40Z
dc.date.issued2024-04-16
dc.description2023 Otros acuerdos transformativos UCM
dc.description.abstractObjective: To evaluate whether hydroxychloroquine (HCQ) or chloroquine (CQ) are effective for the treatment of oral lichen planus (OLP). Materials and methods: A literature search was conducted in four databases. Clinical studies investigating the effect of HCQ/CQ in patients with OLP were included. Results: Eleven studies were included. Four were RCTs and seven quasi-experimental studies. The studies included 390 patients diagnosed with OLP, of which 326 and 7 received HCQ and CQ, respectively. 46 patients received topical dexamethasone, 5 placebo and 6 griseofulvin as controls. Five studies assessed pain, and all of them obtained pain reduction with the use of HCQ. Six studies reported objective clinical improvement of OLP with the use of HCQ. Five studies that used a subjective scale obtained that 24%-100% of the patients achieved a complete/almost complete improvement of OLP lesions and its symptomatology. The most frequent side effects were vision problems, gastric discomfort, rash, nauseas, headaches, skin pigmentation, and elevated kidney function. 17 patients had to withdraw from the studies. Conclusions: Current evidence is scarce to confirm HCQ as a therapeutic option for OLP. More RCTs are needed to compare its efficacy with topical corticosteroids and to evaluate whether HCQ reduces relapses of OLP.
dc.description.departmentDepto. de Especialidades Clínicas Odontológicas
dc.description.facultyFac. de Odontología
dc.description.fundingtypeAPC financiada por la UCM
dc.description.refereedTRUE
dc.description.statuspub
dc.identifier.citationTillero, R., González-Serrano, J., Caponio, V. C. A., Serrano, J., Hernández, G., & López-Pintor, R. M. (2024). Efficacy of antimalarials in oral lichen planus: A systematic review. Oral Diseases, 00, 1–15
dc.identifier.doi10.1111/odi.14975
dc.identifier.essn1601-0825
dc.identifier.issn1354-523X
dc.identifier.officialurlhttps://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/odi.14975
dc.identifier.pmid38720635
dc.identifier.urihttps://hdl.handle.net/20.500.14352/104829
dc.issue.number00
dc.journal.titleOral diseases
dc.language.isoeng
dc.page.final15
dc.page.initial1
dc.publisherWiley
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.cdu616.31
dc.subject.keywordAntimalarials
dc.subject.keywordHydroxychloroquine
dc.subject.keywordChloroquine
dc.subject.keywordOral lichen planus
dc.subject.keywordTreatment
dc.subject.ucmCiencias Biomédicas
dc.subject.ucmOdontología (Odontología)
dc.subject.unesco32 Ciencias Médicas
dc.subject.unesco3213.13 Ortodoncia-Estomatología
dc.titleEfficacy of antimalarials in oral lichen planus: a systematic review
dc.typejournal article
dc.type.hasVersionVoR
dspace.entity.typePublication
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