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MicroRNAs in T Cell-Immunotherapy

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dc.contributor.authorDosil, Sara
dc.contributor.authorRodríguez-Galán, Ana
dc.contributor.authorSánchez-Madrid, Francisco
dc.contributor.authorFernández Messina, Lola María
dc.date.accessioned2024-01-31T14:03:26Z
dc.date.available2024-01-31T14:03:26Z
dc.date.issued2022
dc.descriptionFunding This manuscript was funded by grants AEI/10.13039/501100011033, PID-2020-120412RB-I100 and PDC2021-121797-I00 (F.S.-M.) from the Spanish Ministry of Economy and Competitiveness; CAM (S2017/BMD-3671-INFLAMUNE-CM) from the Comunidad de Madrid (F.S.-M.), CIBERCV (CB16/11/00272) and BIOIMID PIE13/041 from the Instituto de Salud Carlos “la Caixa” Foundation under the project code HR17-00016. The current research is supported by AECC-Coordinated Grant 2022 (PRYCO223002PEIN). The CNIC is supported by the Ministerio de Ciencia, Innovacion y Universidades and the Pro-CNIC Foundation, and is a Severo Ochoa Center of Excellence (SEV-2015-0505). IMDEA Nanociencia acknowledges support from the ‘Severo Ochoa’ Programme for Centres of Excellence in R&D (MINECO, CEX2020-001039-S). S.G.D. is supported by a grant from the Spanish Ministry of Universities.
dc.description.abstractMicroRNAs (miRNAs) act as master regulators of gene expression in homeostasis and disease. Despite the rapidly growing body of evidence on the theranostic potential of restoring miRNA levels in pre-clinical models, the translation into clinics remains limited. Here, we review the current knowledge of miRNAs as T-cell targeting immunotherapeutic tools, and we offer an overview of the recent advances in miRNA delivery strategies, clinical trials and future perspectives in RNA interference technologies.
dc.description.departmentDepto. de Biología Celular
dc.description.facultyFac. de Ciencias Biológicas
dc.description.refereedTRUE
dc.description.sponsorshipComunidad de Madrid
dc.description.sponsorshipMinisterio de Economía y Competitividad (España)
dc.description.sponsorshipMinisterio de Ciencia, Innovación y Universidades (España)
dc.description.statuspub
dc.identifier.citationDosil, S.G.; Rodríguez-Galán, A.; Sánchez-Madrid, F.; Fernández-Messina, L. MicroRNAs in T Cell-Immunotherapy. Int. J. Mol. Sci. 2023, 24, 250. https://doi.org/10.3390/ijms24010250
dc.identifier.doi10.3390/ijms24010250
dc.identifier.essn1422-0067
dc.identifier.officialurlhttps://doi.org/10.3390/ijms24010250
dc.identifier.relatedurlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820302/
dc.identifier.urihttps://hdl.handle.net/20.500.14352/97239
dc.issue.number1
dc.journal.titleInternational Journal of Molecular Sciences
dc.language.isoeng
dc.publisherMDPI
dc.relation.projectIDAEI/10.13039/501100011033
dc.relation.projectIDPID-2020-120412RB-I100
dc.relation.projectIDPDC2021-121797-I00
dc.relation.projectIDS2017/BMD-3671
dc.relation.projectIDCB16/11/00272
dc.relation.projectIDPIE13/041
dc.relation.projectIDHR17-00016
dc.relation.projectIDPRYCO223002PEIN
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.cdu576
dc.subject.cdu577.2
dc.subject.cdu612.017
dc.subject.keywordmicroRNAs (miRNAs)
dc.subject.keywordAntagomiRNAs (antagomiRs)
dc.subject.keywordImmunotherapy
dc.subject.keywordT cell immunotherapy
dc.subject.keywordNanoparticles (NPs)
dc.subject.keywordNanomedicine
dc.subject.keywordmiRNA delivery
dc.subject.ucmBiología celular (Biología)
dc.subject.ucmBiología molecular (Biología)
dc.subject.ucmInmunología
dc.subject.ucmMateriales
dc.subject.unesco2407 Biología Celular
dc.subject.unesco2415 Biología Molecular
dc.subject.unesco2412 Inmunología
dc.titleMicroRNAs in T Cell-Immunotherapy
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number24
dspace.entity.typePublication
relation.isAuthorOfPublication126242c8-e6a6-4bae-a933-30606641554d
relation.isAuthorOfPublication.latestForDiscovery126242c8-e6a6-4bae-a933-30606641554d

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