Predictive Model of Anxiety and Depression Perception in Multiple Sclerosis Patients: Possible Implications for Clinical Treatment

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dc.contributor.authorCuerda Ballester, María
dc.contributor.authorBustos, Antonio
dc.contributor.authorSancho Cantus, David
dc.contributor.authorMartínez Rubio, David
dc.contributor.authorPrivado Zamorano, Jesús
dc.contributor.authorAlarcón Jiménez, Jorge
dc.contributor.authorVillarón Casales, Carlos
dc.contributor.authorBernardo Tejedor, Nieves De
dc.contributor.authorNavarro Illana, Esther
dc.contributor.authorRubia Ortí, José Enrique De La
dc.date.accessioned2024-06-14T15:35:10Z
dc.date.available2024-06-14T15:35:10Z
dc.date.issued2024-01-22
dc.description2024 Descuento MDPI
dc.description.abstractMultiple Sclerosis (MS) is a neurodegenerative disease characterized by motor and non-motor symptoms, including emotional distress, anxiety, and depression. These emotional symptoms currently have a pharmacological treatment with limited effectiveness; therefore, it is necessary to delve into their relationship with other psychological, functional, or prefrontal alterations. Additionally, exploring non-pharmacological therapeutic alternatives that have shown benefits in addressing emotional distress in MS patients is essential. Aim: To establish a predictive model for the presence of anxiety and depression in MS patients, based on variables such as psychological well-being, functional activity, and prefrontal symptoms. Additionally, this study aimed to propose non-pharmacological therapeutic alternatives based on this model. Materials and Methods: A descriptive, observational, and cross-sectional study was conducted with a sample of 64 diagnosed MS patients who underwent functional and cognitive assessments using the following questionnaires and scales: Functional Activities Questionnaire (FAQ), Acceptance and Action Questionnaire (AAQ-II), Experiences Questionnaire (EQ), Self-Compassion Scale Short Form (SCS-SF), Beck Depression Inventory II (BDI-II), State-Trait Anxiety Inventory (STAI), and Prefrontal Symptoms Inventory (PSI). Results: The model showed an excellent fit to the data and indicated that psychological well-being was the most significant predictor of the criteria (β = −0.83), followed by functional activity (β = −0.18) and prefrontal symptoms (β = 0.15). The latter two are negatively related to psychological well-being (β = −0.16 and β = −0.75, respectively). Conclusions: Low psychological well-being is the variable that most significantly predicts the presence of anxiety and depression in MS patients, followed by functional activity and prefrontal alterations. Interventions based on mindfulness and acceptance are recommended, along with nutritional interventions such as antioxidant-enriched ketogenic diets and moderate group physical exercise.eng
dc.description.departmentDepto. de Psicobiología y Metodología en Ciencias del Comportamiento
dc.description.facultyFac. de Psicología
dc.description.fundingtypeDescuento UCM
dc.description.refereedTRUE
dc.description.sponsorshipCatholic University Foundation San Vicente Mártir
dc.description.statuspub
dc.identifier.citationCuerda-Ballester, M., Bustos, A., Sancho-Cantus, D., Martínez-Rubio, D., Privado, J., Alarcón-Jiménez, J., Villarón-Casales, C., De Bernardo, N., Navarro Illana, E., & De La Rubia Ortí, J. E. (2024). Predictive model of anxiety and depression perception in multiple sclerosis patients: Possible implications for clinical treatment. Bioengineering, 11(1), 100. https://doi.org/10.3390/bioengineering11010100
dc.identifier.doi10.3390/bioengineering11010100
dc.identifier.officialurlhttps://doi.org/10.3390/bioengineering11010100
dc.identifier.relatedurlhttps://www.mdpi.com/2306-5354/11/1/100
dc.identifier.urihttps://hdl.handle.net/20.500.14352/104966
dc.issue.number1
dc.journal.titleBioengineering
dc.language.isoeng
dc.page.final114
dc.page.initial100
dc.publisherMDPI
dc.rightsATTRIBUTION 4.0 INTERNATIONAL
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject.cdu159.9.075:616-056.24
dc.subject.keywordMultiple sclerosis
dc.subject.keywordanxiety
dc.subject.keyworddepression
dc.subject.keywordpsychological well-being
dc.subject.keywordfunctional activity
dc.subject.keywordprefrontal activity
dc.subject.ucmPsicología (Psicología)
dc.subject.unesco3211 Psiquiatría
dc.titlePredictive Model of Anxiety and Depression Perception in Multiple Sclerosis Patients: Possible Implications for Clinical Treatment
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number11
dspace.entity.typePublication
relation.isAuthorOfPublicationf7ed11e6-f3b9-42e4-a11c-dbf3e0270aca
relation.isAuthorOfPublication.latestForDiscoveryf7ed11e6-f3b9-42e4-a11c-dbf3e0270aca
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