Combined Effect of Genetic Variants on Long-Term Weight Response after Bariatric Surgery

Simple item page
dc.contributor.authorTorrego-Ellacuría, Macarena
dc.contributor.authorBarabash Bustelo, Ana
dc.contributor.authorMatía Martín, María Del Pilar
dc.contributor.authorSánchez Pernaute, Andrés
dc.contributor.authorTorres García, Antonio José
dc.contributor.authorCalle Pascual, Alfonso Luis
dc.contributor.authorRubio Herrera, Miguel Ángel
dc.date.accessioned2024-04-25T15:53:46Z
dc.date.available2024-04-25T15:53:46Z
dc.date.issued2023-06-26
dc.description.abstractThe pathophysiology of body weight control involves complex interactions between hormonal, environmental, behavioral and genetic factors. The purpose of this study was to analyze the association between single nucleotide polymorphisms (SNPs) of 13 genes encoding gastrointestinal peptides, their receptors or the proteins involved in their expression, with long-term weight response in a cohort of 375 patients undergoing bariatric surgery (BS). To evaluate weight response, we combined several variables to define specific response phenotypes six years after surgery. The study protocol was registered in ISRCTN (ID80961259). The analysis of the selected SNPs was performed via allelic discrimination using Taqman® probes (Applied Biosystems, Foster City, CA, USA). The genotype association study was performed using the SNPstat program, with comparisons adjusted for sex, age, initial body mass index, type 2 diabetes, hypertension diagnosis and the type of surgery. We identified eight genetic variants associated with the weight response to BS, independently of the presurgery patient profile and the type of surgical technique, from which we calculated the unweighted risk score (RS) for each phenotype. The highest scoring category in each RS was significantly associated with lower weight loss (p = 0.0001) and greater weight regain (p = 0.0012) at the end of the follow-up.
dc.description.departmentDepto. de Medicina
dc.description.facultyFac. de Medicina
dc.description.fundingtypeDescuento UCM
dc.description.refereedTRUE
dc.description.sponsorshipFundación Mutua Madrileña
dc.description.sponsorshipFundación Estudios Metabólicos
dc.description.statuspub
dc.identifier.citationTorrego-Ellacuría, M.; Barabash, A.; Matía-Martín, P.; Sánchez-Pernaute, A.; Torres, A.J.; Calle-Pascual, A.L.; Rubio-Herrera, M.A. Combined Effect of Genetic Variants on Long-Term Weight Response after Bariatric Surgery. J. Clin. Med. 2023, 12, 4288. https://doi.org/10.3390/jcm12134288
dc.identifier.doi10.3390/jcm12134288
dc.identifier.officialurl10.3390/jcm12134288
dc.identifier.relatedurlhttps://www.mdpi.com/2077-0383/12/13/4288
dc.identifier.urihttps://hdl.handle.net/20.500.14352/103522
dc.issue.number13
dc.journal.titleJournal of Clinical Medicine
dc.language.isoeng
dc.page.initial4288
dc.publisherMPDI
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.cdu616.1/.9
dc.subject.keywordRisk score
dc.subject.keywordSNP
dc.subject.keywordBariatric surgery
dc.subject.keywordWeight regain
dc.subject.keywordWeight loss
dc.subject.ucmMedicina interna
dc.subject.unesco3205 Medicina Interna
dc.titleCombined Effect of Genetic Variants on Long-Term Weight Response after Bariatric Surgery
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number12
dspace.entity.typePublication
relation.isAuthorOfPublicationfb69167e-fa1d-4afa-8b0b-aa750a25845e
relation.isAuthorOfPublication7879ca03-671d-4844-b217-477e7f26e6d1
relation.isAuthorOfPublication64ea548c-394b-4f2a-aeaa-2341b7416dc1
relation.isAuthorOfPublication790390e8-2a0b-4dca-9996-3e85d11acad7
relation.isAuthorOfPublication669efe68-8a95-4bc4-8fdd-32f26bbe31d2
relation.isAuthorOfPublication54bfb565-4a99-41ce-a708-42a43080f9a3
relation.isAuthorOfPublication.latestForDiscoveryfb69167e-fa1d-4afa-8b0b-aa750a25845e
Download
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
jcm-12-04288-v3.pdf
Size:
866.87 KB
Format:
Adobe Portable Document Format
downoload Download
Collections
Artículos