Real-time fMRI neurofeedback reduces auditory hallucinations and modulates resting state connectivity of involved brain regions: Part 2: Default mode network -preliminary evidence

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dc.contributor.authorClemens C.C. Bauer
dc.contributor.authorKana Okano
dc.contributor.authorSatrajit S. Ghosh
dc.contributor.authorYoon Ji Lee
dc.contributor.authorCarlo de los Angeles
dc.contributor.authorPaul G. Nestor
dc.contributor.authorElisabetta C. del Re
dc.contributor.authorGeorg Northoff
dc.contributor.authorMargaret A. Niznikiewicz
dc.contributor.authorSusan Whitfield-Gabrieli
dc.contributor.authorMelero Carrasco, Helena
dc.date.accessioned2024-02-08T10:52:55Z
dc.date.available2024-02-08T10:52:55Z
dc.date.issued2020-02
dc.description.abstractAuditory hallucinations (AHs) are one of the most distressing symptoms of schizophrenia (SZ) and are often resistant to medication. Imaging studies of individuals with SZ show hyperactivation of the default mode network (DMN) and the superior temporal gyrus (STG). Studies in SZ show DMN hyperconnectivity and reduced anticorrelation between DMN and the central executive network (CEN). DMN hyperconnectivity has been associated with positive symptoms such as AHs while reduced DMN anticorrelations with cognitive impairment. Using real-time fMRI neurofeedback (rt-fMRI-NFB) we trained SZ patients to modulate DMN and CEN networks. Meditation is effective in reducing AHs in SZ and to modulate brain network integration and increase DMN anticorrelations. Consequently, patients were provided with meditation strategies to enhance their abilities to modulate DMN/CEN. Results show a reduction of DMN hyperconnectivity and increase in DMNsingle bondCEN anticorrelation. Furthermore, the change in individual DMN connectivity significantly correlated with reductions in AHs. This is the first time that meditation enhanced through rt-fMRI-NFB is used to reduce AHs in SZ. Moreover, it provides the first empirical evidence for a direct causal relation between meditation enhanced rt-fMRI-NFB modulation of DMNsingle bondCEN activity and post-intervention modulation of resting state networks ensuing in reductions in frequency and severity of AHs.
dc.description.departmentDepto. de Psicobiología y Metodología en Ciencias del Comportamiento
dc.description.facultyFac. de Psicología
dc.description.refereedTRUE
dc.description.statuspub
dc.identifier.citationBauer CCC, Okano K, Ghosh SS, Lee YJ, Melero H, Angeles C de L, et al. Real-time fMRI neurofeedback reduces auditory hallucinations and modulates resting state connectivity of involved brain regions: Part 2: Default mode network -preliminary evidence. Psychiatry Res [Internet]. 2020;284(112770):112770.
dc.identifier.doi10.1016/j.psychres.2020.112770
dc.identifier.essn0165-1781
dc.identifier.issn0165-1781
dc.identifier.officialurlhttps://www.sciencedirect.com/science/article/abs/pii/S0165178119321201?via%3Dihub
dc.identifier.urihttps://hdl.handle.net/20.500.14352/100314
dc.issue.numberFebruary 2020
dc.journal.titlePsychiatry Research
dc.language.isoeng
dc.page.initial112770
dc.publisherScience Direct (Elsevier)
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.accessRightsrestricted access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.cdu616.89
dc.subject.cdu616.895.8
dc.subject.cdu616.89-008.42
dc.subject.cdu615.851.8
dc.subject.keywordMindfulness meditation
dc.subject.keywordSchizophrenia
dc.subject.keywordAuditory hallucinations
dc.subject.keywordReal-time neurofeedbac
dc.subject.keywordDefault mode network
dc.subject.ucmPsiquiatría
dc.subject.unesco2490 Neurociencias
dc.titleReal-time fMRI neurofeedback reduces auditory hallucinations and modulates resting state connectivity of involved brain regions: Part 2: Default mode network -preliminary evidence
dc.typejournal article
dc.type.hasVersionAM
dc.volume.number284
dspace.entity.typePublication
relation.isAuthorOfPublication17bc1fff-dc5d-4ac3-914e-dd631e6a9ac1
relation.isAuthorOfPublication.latestForDiscovery17bc1fff-dc5d-4ac3-914e-dd631e6a9ac1
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