First evidence on the role of palmitoylethanolamide in energy homeostasis in fish

Simple item page
dc.contributor.authorGómez-Boronat, Miguel
dc.contributor.authorIsorna Alonso, Esther
dc.contributor.authorConde-Sieira, Marta
dc.contributor.authorDelgado Saavedra, María Jesús
dc.contributor.authorSoengas, José L.
dc.contributor.authorPedro Ormeño, Nuria de
dc.date.accessioned2023-06-16T15:15:36Z
dc.date.available2023-06-16T15:15:36Z
dc.date.issued2020-01
dc.description.abstractThe objective of this study was to investigate the role of palmitoylethanolamide (PEA) in the regulation of energy homeostasis in goldfish (Carassius auratus). We examined the effects of acute or chronic intraperitoneal treatment with PEA (20 μg·g−1 body weight) on parameters related to food intake and its regulatory mechanisms, locomotor activity, glucose and lipid metabolism, and the possible involvement of transcription factors and clock genes on metabolic changes in the liver. Acute PEA treatment induced a decrease in food intake at 6 and 8 h postinjection, comparable to that observed in mammals. This PEA anorectic effect in goldfish could be mediated through interactions with leptin and NPY, as PEA increased hepatic expression of leptin aI and reduced hypothalamic expression of npy. The PEA chronic treatment reduced weight gain, growth rate, and locomotor activity. The rise in glycolytic potential together with the increased potential of glucose to be transported into liver suggests an enhanced use of glucose in the liver after PEA treatment. In addition, part of glucose may be exported to be used in other tissues. The activity of fatty acid synthase (FAS) increased after chronic PEA treatment, suggesting an increase in the hepatic lipogenic capacity, in contrast with the mammalian model. Such lipogenic increment could be linked with the PEA-induction of REV-ERBα and BMAL1 found after the chronic treatment. As a whole, the present study shows the actions of PEA in several compartments related to energy homeostasis and feeding behavior, supporting a regulatory role for this N-acylethanolamine in fish.
dc.description.departmentDepto. de Genética, Fisiología y Microbiología
dc.description.facultyFac. de Ciencias Biológicas
dc.description.refereedTRUE
dc.description.sponsorshipAgencia Estatal de Investigación (AEI)-Fondo Europeo de Desarollo Regional
dc.description.sponsorshipAgencia Estatal de Investigación (AEI)
dc.description.sponsorshipXunta de Galicia
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/58587
dc.identifier.doi10.1016/j.yhbeh.2019.104609
dc.identifier.issn0018-506X, ESSN: 1095-6867
dc.identifier.officialurlhttps://www.sciencedirect.com/science/article/pii/S0018506X19302326
dc.identifier.urihttps://hdl.handle.net/20.500.14352/6004
dc.issue.number104609
dc.journal.titleHormones and Behavior
dc.language.isoeng
dc.page.final12
dc.page.initial1
dc.publisherElsevier
dc.relation.projectID(AGL2016-74857-C3-1-R)
dc.relation.projectID(AGL2016-74857-C3-2-R)(BES-2014-068103)(AGL2016-81808-REDT)
dc.relation.projectID(ED481B2018/018)
dc.rights.accessRightsrestricted access
dc.subject.cdu597.5
dc.subject.cdu591.1
dc.subject.keywordPEA
dc.subject.keywordFood intake
dc.subject.keywordBody weight
dc.subject.keywordLocomotor activity
dc.subject.keywordLipid metabolism
dc.subject.keywordGlucose metabolism
dc.subject.keywordLiver
dc.subject.keywordPPAR
dc.subject.keywordREV-ERB
dc.subject.keywordClock genes
dc.subject.ucmFisiología animal (Biología)
dc.subject.ucmPeces
dc.subject.unesco2401.13 Fisiología Animal
dc.titleFirst evidence on the role of palmitoylethanolamide in energy homeostasis in fish
dc.typejournal article
dc.volume.number117
dspace.entity.typePublication
relation.isAuthorOfPublication882d1fb3-a920-418a-9f3f-1b8f6b967032
relation.isAuthorOfPublication48071251-a236-4607-ab33-5332c1472628
relation.isAuthorOfPublication.latestForDiscovery882d1fb3-a920-418a-9f3f-1b8f6b967032
Download
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Gómez-Boronat, M. et al. 2019. First evidence on the role of palmitoylethanolamide.....pdf
Size:
1.98 MB
Format:
Adobe Portable Document Format
Download
Collections
Artículos