Beneficial Effects of Olive Oil Enriched with Lycopene on the Plasma Antioxidant and Anti-Inflammatory Profile of Hypercholesterolemic Patients

Simple item page
dc.contributor.authorMartínez Álvarez, Jesús Román
dc.contributor.authorLopez Jaen, Ana Belen
dc.contributor.authorCavia Saiz, Monica
dc.contributor.authorMuñiz, Pilar
dc.contributor.authorValls Belles, Victoria
dc.date.accessioned2024-05-30T17:39:24Z
dc.date.available2024-05-30T17:39:24Z
dc.date.issued2023-07-20
dc.description2023 Descuentos MDPI
dc.description.abstractOlive oil and lycopene are foods that have potent antioxidant activity. The objective was to determine the effects of consumption of olive oil enriched with lycopene on oxidative stress biomarkers in hypercholesterolemic subjects. We examined the effects of oil enriched with lycopene extract daily intake during 1 month on plasma antioxidant capacity, lipids profile (triacylgycerols, total cholesterol, cHDL; cLDL, ox-LDL), biomarkers of oxidative stress, and inflammatory markers related with atherosclerosis risk (C-reactive protein (CRP), IL-6; sDC4L) in subjects hypercholesteremics (cholesterol > 220 mg/dL). In the group consuming olive oil-lycopene, significant increases (p < 0.05) in the levels of plasma lycopene concentration (0.146 ± 0.03 versus 0.202 ± 0.04 (µmol/L)), α-carotene (0.166 ± 0.064 versus 0.238 ± 0.07) and in β-carotene (0.493 ± 0.187 versus 0.713 ± 0.221) were observed. These results are linked with the increases of plasma antioxidants and decreases biomarkers of oxidative stress (carbonyl groups, malondialdehyde and 8-hydroxy-deoxiguanosine) observed in hypercholesterolemic group. In relation to lipid profile, a significant decrease was observed in the levels of ox-LDL (781 ± 302 versus 494 ± 200), remaining unchanged the levels of TG, cholesterol, HDL and LDL-c. Regarding inflammatory biomarkers, the levels of CRP and IL-6 decreased significantly. The positive results obtained in this study support the use of olive oil enriched with lycopene to reduce the risk of coronary disease.
dc.description.departmentDepto. de Enfermería
dc.description.facultyFac. de Enfermería, Fisioterapia y Podología
dc.description.fundingtypeDescuento UCM
dc.description.refereedTRUE
dc.description.statuspub
dc.identifier.citationMartínez Álvarez, J.R.; Lopez Jaen, A.B.; Cavia-Saiz, M.; Muñiz, P.; Valls-Belles, V. Beneficial Effects of Olive Oil Enriched with Lycopene on the Plasma Antioxidant and Anti-Inflammatory Profile of Hypercholesterolemic Patients. Antioxidants 2023, 12, 1458. https://doi.org/10.3390/antiox12071458
dc.identifier.doi10.3390/antiox12071458
dc.identifier.issn2076-3921
dc.identifier.officialurlhttps://doi.org/10.3390/antiox12071458
dc.identifier.relatedurlhttps://www.mdpi.com/2076-3921/12/7/1458
dc.identifier.urihttps://hdl.handle.net/20.500.14352/104618
dc.issue.number7
dc.journal.titleAntioxidants
dc.language.isoeng
dc.page.initial1458
dc.publisherMDPI
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.cdu614.253.5
dc.subject.keywordlycopene
dc.subject.keywordolive oil
dc.subject.keywordCRP
dc.subject.keywordcholesterol
dc.subject.keywordcytokines
dc.subject.keywordantioxidant capacity
dc.subject.keywordoxidative stress biomarkers
dc.subject.ucmCiencias Biomédicas
dc.subject.unesco32 Ciencias Médicas
dc.titleBeneficial Effects of Olive Oil Enriched with Lycopene on the Plasma Antioxidant and Anti-Inflammatory Profile of Hypercholesterolemic Patients
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number12
dspace.entity.typePublication
relation.isAuthorOfPublication86b8b1de-33c5-4554-90a5-bdd8f642b2e5
relation.isAuthorOfPublication.latestForDiscovery86b8b1de-33c5-4554-90a5-bdd8f642b2e5
Download
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Beneficial_Effects_of_Olive.pdf
Size:
1.15 MB
Format:
Adobe Portable Document Format
downoload Download
Collections
Artículos