Multivalent Choline Dendrimers as Potent Inhibitors of Pneumococcal Cell-Wall Hydrolysis

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dc.contributor.authorHernandez-Rocamora, V.M.
dc.contributor.authorMaestro García-Donas, María Beatriz
dc.contributor.authorde Waal, B.
dc.contributor.authorMorales, M.
dc.contributor.authorGarcia, P.
dc.contributor.authorMeijer, E. W.
dc.contributor.authorSanz, J.M.
dc.date.accessioned2024-01-16T15:39:57Z
dc.date.available2024-01-16T15:39:57Z
dc.date.issued2009-01-13
dc.description.abstractDendritic cell-wall mimics: Choline-binding proteins from Streptococcus pneumoniae recognize distinctive multivalent choline architectures on the bacterial cell wall. Choline-functionalized dendrimers are potent inhibitors of these essential enzymes, with a 103–104-fold higher affinity than free choline, resulting in inhibition of autolysis and cell separation in bacterial cultures at low micromolar concentrations
dc.description.departmentDepto. de Bioquímica y Biología Molecular
dc.description.facultyFac. de Ciencias Biológicas
dc.description.refereedTRUE
dc.description.sponsorshipEscuela Valenciana de Estudios para la Salud
dc.description.sponsorshipFundación Salvat Inquifarma
dc.description.sponsorshipMinisterio de Educación y Ciencia (MEC)
dc.description.sponsorshipInstituto de Salud Carlos III
dc.description.sponsorshipComunidad de Madrid
dc.description.sponsorshipNetherlands Organisation for Scientific Research
dc.description.statuspub
dc.identifier.doi10.1002/anie.200803664
dc.identifier.essn1521-3773
dc.identifier.issn1433-7851
dc.identifier.officialurlhttps://onlinelibrary.wiley.com/doi/10.1002/anie.200803664
dc.identifier.urihttps://hdl.handle.net/20.500.14352/93420
dc.issue.number5
dc.journal.titleAngewandte Chemie International Edition
dc.language.isoeng
dc.page.final951
dc.page.initial948
dc.publisherWiley
dc.relation.projectID(S-BIO-0260/2006)
dc.relation.projectID(95/2005)
dc.relation.projectID(700.56.428)
dc.rights.accessRightsrestricted access
dc.subject.cdu577.1
dc.subject.ucmBioquímica (Química)
dc.subject.unesco2403 Bioquímica
dc.titleMultivalent Choline Dendrimers as Potent Inhibitors of Pneumococcal Cell-Wall Hydrolysis
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number48
dspace.entity.typePublication
relation.isAuthorOfPublication1995e084-52c0-4061-bc50-a5aaeca4ec7a

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