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Human supplementation with AM3, spermidine, and hesperidin enhances immune function, decreases biological age, and improves oxidative–inflammatory state: A randomized controlled trial

dc.contributor.authorFélix Escalera, Judith
dc.contributor.authorDíaz Del Cerro, Estefanía
dc.contributor.authorBaca Muñoz, Adriana
dc.contributor.authorLópez Ballesteros, Ana
dc.contributor.authorGómez Sánchez, María José
dc.contributor.authorFuente Del Rey, María Mónica De La
dc.date.accessioned2025-01-29T18:43:41Z
dc.date.available2025-01-29T18:43:41Z
dc.date.issued2024-11
dc.description.abstractThe positive effect of AM3, spermidine, and hesperidin, which have antioxidant and anti-inflammatory properties, on immunity is known, but their effect on the rate of aging, known as biological age (BA), is unclear. This work aims to test if the intake of a blend of AM3 (150 mg), spermidine (0.6 mg), and hesperidin (50 mg) for 2 months could decrease BA and improve immunity, redox, and inflammatory states. For this, 41 participants (30–63 years) were randomly divided into placebo and supplement groups. The supplement group took two capsules daily with AM3, spermidine, and hesperidin for two months, while the placebo group took capsules containing only calcium phosphate and talcum powder. Before and after the treatment, peripheral blood was collected. Immune function was assessed in leukocytes, redox state in whole-blood cells, erythrocytes, and plasma, and cytokine concentration in both mononuclear cell cultures and plasma. Finally, the Immunity Clock model was applied to determine BA. The results show that the intake of this blend improves the immune functions that constitute the Immunity Clock, decreasing BA by 11 years and reducing the oxidative–inflammatory state of the participants. Therefore, this supplement can be proposed as a strategy to rejuvenate BA and achieve healthy aging.
dc.description.departmentDepto. de Genética, Fisiología y Microbiología
dc.description.facultyFac. de Ciencias Biológicas
dc.description.refereedTRUE
dc.description.sponsorshipIndustrial Farmacéutica Cantabria
dc.description.statuspub
dc.identifier.citationFélix J, Díaz-Del Cerro E, Baca A, López-Ballesteros A, Gómez-Sánchez MJ, De La Fuente M. Human Supplementation with AM3, Spermidine, and Hesperidin Enhances Immune Function, Decreases Biological Age, and Improves Oxidative–Inflammatory State: A Randomized Controlled Trial. Antioxidants 2024;13:1391. https://doi.org/10.3390/antiox13111391.
dc.identifier.doi10.3390/antiox13111391
dc.identifier.essn2076-3921
dc.identifier.officialurlhttps://doi.org/10.3390/antiox13111391
dc.identifier.relatedurlhttps://www.mdpi.com/2076-3921/13/11/1391
dc.identifier.urihttps://hdl.handle.net/20.500.14352/117048
dc.issue.number11
dc.journal.titleAntioxidants
dc.language.isoeng
dc.page.final16
dc.page.initial1
dc.publisherMDPI
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.cdu612.017
dc.subject.cdu577.21
dc.subject.cdu615.03
dc.subject.keywordAM3
dc.subject.keywordSpermidine
dc.subject.keywordHesperidin
dc.subject.keywordImmunity
dc.subject.keywordBiological age
dc.subject.keywordRedox state
dc.subject.keywordInflammatory state
dc.subject.ucmBioquímica (Biología)
dc.subject.ucmInmunología
dc.subject.ucmFisiología
dc.subject.ucmFarmacología (Medicina)
dc.subject.unesco2410.10 Fisiología Humana
dc.subject.unesco2302.04 Genética Bioquímica
dc.subject.unesco2412 Inmunología
dc.subject.unesco3209 Farmacología
dc.titleHuman supplementation with AM3, spermidine, and hesperidin enhances immune function, decreases biological age, and improves oxidative–inflammatory state: A randomized controlled trial
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number13
dspace.entity.typePublication
relation.isAuthorOfPublication41edd86f-bb6c-471c-ad9a-81b7c9ebf374
relation.isAuthorOfPublication93b65450-f7e4-4ffa-826d-aa98e14f95a5
relation.isAuthorOfPublication46f6aefd-3a5c-40ed-aa92-f0198ce45fd3
relation.isAuthorOfPublication.latestForDiscovery41edd86f-bb6c-471c-ad9a-81b7c9ebf374

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