Strontium-Modified Scaffolds Based on Mesoporous Bioactive Glasses/Polyvinyl Alcohol Composites for Bone Regeneration

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dc.contributor.authorJiménez Holguín, Javier
dc.contributor.authorLópez Hidalgo, Álvaro
dc.contributor.authorSánchez Salcedo, Sandra
dc.contributor.authorPeña Martínez, Juan
dc.contributor.authorVallet Regí, María Dulce Nombre
dc.contributor.authorSalinas Sánchez, Antonio J.
dc.date.accessioned2023-06-17T08:56:10Z
dc.date.available2023-06-17T08:56:10Z
dc.date.issued2020-12-03
dc.descriptionRESEARCH ID N-4501-2014  (Sandra Sánchez Salcedo) ORCID 0000-0002-1889-2057 (Sandra Sánchez Salcedo) RESEARCHER ID M-3378-2014 (María Vallet Regí) ORCID 0000-0002-6104-4889 (María Vallet Regí) RESEARCH ID M-3316-2014 (Antonio Salinas Sánchez) ORCID 0000-0002-8408-3389 (Antonio Salinas Sánchez)
dc.description.abstractIn the search of a new biomaterial for the treatment of bone defects resulting from traumatic events, an osteoporosis scenario with bone fractures, tumor removal, congenital pathologies or implant revisions for infection, we developed 3D scaffolds based on mesoporous bioactive glasses (MBGs) (85−x)SiO2–5P2O5–10CaO–xSrO (x = 0, 2.5 and 5 mol.%). The scaffolds with meso-macroporosity were fabricated by pouring a suspension of MBG powders in polyvinyl alcohol (PVA) into a negative template of polylactic acid (PLA), followed by removal of the template by extraction at low temperature. SrO-containing MBGs exhibited excellent properties for bone substitution including ordered mesoporous structure, high textural properties, quick in vitro bioactive response in simulated body fluid (SBF) and the ability of releasing concentrations of strontium ions able to stimulate expression of early markers of osteoblastic differentiation. Moreover, the direct contact of MC3T3-E1 pre-osteoblastic cells with the scaffolds confirmed the cytocompatibility of the three compositions investigated. Nevertheless, the scaffold containing 2.5% of SrO induced the best cellular proliferation showing the potential of this scaffold as a candidate to be further investigated in vitro and in vivo, aiming to be clinically used for bone regeneration applications in non-load bearing sites.
dc.description.departmentDepto. de Química en Ciencias Farmacéuticas
dc.description.facultyFac. de Farmacia
dc.description.refereedTRUE
dc.description.sponsorshipUnión Europea. Horizonte 2020
dc.description.sponsorshipInstituto de Salud Carlos III/FEDER (European Regional Development Fund)
dc.description.sponsorshipComunidad de Madrid
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/63281
dc.identifier.doi10.3390/ma13235526
dc.identifier.issn1996-1944
dc.identifier.officialurlhttps://www.mdpi.com/journal/materials
dc.identifier.relatedurlhttps://www.ucm.es/valletregigroup
dc.identifier.urihttps://hdl.handle.net/20.500.14352/7577
dc.journal.titleMaterials
dc.language.isoeng
dc.page.initial5526
dc.publisherMDPI
dc.relation.projectIDVERDI (694160)
dc.relation.projectIDPI15/00978
dc.relation.projectIDPEJ-2017-2017-AI/SALl-5825
dc.rightsAtribución 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/es/
dc.subject.keywordmesoporous glass scaffolds
dc.subject.keywordSrO
dc.subject.keywordcytocompatibility
dc.subject.keywordpre-osteoblastic cells
dc.subject.ucmMateriales
dc.subject.unesco3312 Tecnología de Materiales
dc.titleStrontium-Modified Scaffolds Based on Mesoporous Bioactive Glasses/Polyvinyl Alcohol Composites for Bone Regeneration
dc.typejournal article
dc.volume.number13
dspace.entity.typePublication
relation.isAuthorOfPublication82cf0840-5331-47de-a3ab-797fab8b9132
relation.isAuthorOfPublication14ed7f4d-b114-4a3c-9d8c-83f05fbfc703
relation.isAuthorOfPublication7a1a0bea-5336-46a9-abdb-7b043459b994
relation.isAuthorOfPublication791023b8-2531-44eb-ba01-56e3b7caa0cb
relation.isAuthorOfPublication.latestForDiscovery82cf0840-5331-47de-a3ab-797fab8b9132
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