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Bone marrow trephine biopsy involvement by lymphoma: pattern of involvement and concordance with flow cytometry, in 10 years from a single institution

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dc.contributor.authorCabezas Quintario, María Antonia
dc.contributor.authorGomez Iglesias, Patricia
dc.contributor.authorYuste Del Pozo, Verónica
dc.contributor.authorValencia Mesa, Ana
dc.contributor.authorSosa, Grevelyn
dc.contributor.authorRicard, Patricia
dc.contributor.authorHijas Gómez, Ana
dc.contributor.authorPinedo, Fernando
dc.contributor.authorArguelles, Miguel
dc.date.accessioned2025-01-28T07:54:10Z
dc.date.available2025-01-28T07:54:10Z
dc.date.issued2015-08-27
dc.description.abstractPurpose: To evaluate the features of bone marrow (BM) biopsy involvement by lymphoma, pattern of infiltration, morphological analysis and flow cytometry were reviewed at all lymphoma patients over a period of 10 years. Methods/patients: 413 cases were included in the study if BM biopsy slides were available. Only 356 patients had both BM trephine biopsy and flow cytometry. Results: The most frequent subtype was diffuse large B cell (31.2%), followed by follicular lymphoma (18.9%). The predominant pattern was mixed (nodular-interstitial) (9.2%). Morphological marrow infiltration was found in 138 cases, and flow cytometry identified 117 cases with BM involvement. A concordance between the two methods was detected in 305 cases (85.7%). There was discordance in 51 cases (14.3%): morphology positive/FC negative in 33 cases and morphology negative/FC positive in 18. Conclusions: Flow cytometry is slightly more useful in detecting involvement when the BM is affected, but this finding is not conclusive.
dc.description.departmentDepto. de Medicina Legal, Psiquiatría y Patología
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.statuspub
dc.identifier.citationCabezas-Quintario MA, Gomez P, Yuste-Del Pozo V, Valencia-Mesa AL, Sosa G, Ricard P, et al. Bone marrow trephine biopsy involvement by lymphoma: pattern of involvement and concordance with flow cytometry, in 10 years from a single institution. Clinical and Translational Oncology [Internet]. 2015 Aug 27;18(5):537–40. Available from: http://dx.doi.org/10.1007/s12094-015-1393-9
dc.identifier.doi10.1007/s12094-015-1393-9
dc.identifier.essn1699-3055
dc.identifier.issn1699-048X
dc.identifier.officialurlhttps://doi.org/10.1007/s12094-015-1393-9
dc.identifier.pmid26311078
dc.identifier.relatedurlhttps://link.springer.com/article/10.1007/s12094-015-1393-9
dc.identifier.relatedurlhttps://pubmed.ncbi.nlm.nih.gov/26311078/
dc.identifier.urihttps://hdl.handle.net/20.500.14352/116469
dc.issue.number5
dc.journal.titleClinical and Translational Oncology
dc.language.isoeng
dc.page.final540
dc.page.initial537
dc.publisherSpringer
dc.rights.accessRightsrestricted access
dc.subject.cdu616.1/.9
dc.subject.keywordBone marrow
dc.subject.keywordDiscordance
dc.subject.keywordFlow cytometry
dc.subject.keywordPattern involvement.
dc.subject.ucmCiencias Biomédicas
dc.subject.ucmOncología
dc.subject.unesco32 Ciencias Médicas
dc.subject.unesco3207 Patología
dc.titleBone marrow trephine biopsy involvement by lymphoma: pattern of involvement and concordance with flow cytometry, in 10 years from a single institution
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number18
dspace.entity.typePublication

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