Obesity and periodontitis: An experimental study to evaluate periodontal and systemic effects of comorbidity

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dc.contributor.authorCano, Pilar
dc.contributor.authorGonzález, Jerián
dc.contributor.authorVirto Ruiz, Leire
dc.contributor.authorCano Barquilla, María Pilar
dc.contributor.authorJiménez Ortega, Vanesa
dc.contributor.authorFernández Mateos, María Del Pilar
dc.contributor.authorEsquifino Parras, Ana Isabel
dc.contributor.authorSanz Alonso, Mariano
dc.date.accessioned2024-01-19T18:53:25Z
dc.date.available2024-01-19T18:53:25Z
dc.date.issued2018-02-16
dc.descriptionIssue Online: 01 March 2018 Version of Record online: 16 February 2018 Manuscript accepted: 03 August 2017 Manuscript received: 09 June 2017
dc.description.abstractBackground: Obesity and overweight have been associated with periodontitis. This study aims to evaluate periodontal and systemic effects of this association in a validated experimental model. Methods: Twenty-eight male Wistar rats were randomly divided into four groups: 1) control group (Con) (fed with standard diet); 2) high-fat diet group (HFD) (fed with a diet containing 35.2% fat); 3) control group with induced periodontitis (Con-Perio); and 4) HFD group with induced periodontitis (HFD-Perio). To induce periodontitis, oral gavages with Porphyromonas gingivalis ATCC W83K1 and Fusobacterium nucleatum DMSZ 20482 were used. Periodontal outcomes were evaluated by inflammatory parameters, periodontal probing depth (PD), and modified gingival index (MGI). Systemic effects were evaluated by measuring levels of inflammatory cytokines, insulin, adiponectin, and leptin using multiplex immunoassays and levels of visfatin, resistin, lipid profiles, transaminases, and plasma endotoxin using colorimetric tests and the glucose tolerance test. Results: Clinical parameters (PD and MGI) were significantly increased (P < 0.05) in the induced periodontitis groups compared with controls. The HFD-Perio group demonstrated significantly higher PD compared with Con-Perio group. Lipid profiles, cytokines, and adipocytokines showed significantly elevated levels in the HFD-Perio group compared with the other groups. Similarly, glucose levels in the HFD-Perio group were significantly higher (P < 0.05) than in the HFD group, and hepatic damage parameters demonstrated a tendency toward higher levels in the HFD-Perio group. Conclusion: Obesity and periodontitis demonstrated a comorbidity effect on both systemic inflammatory and metabolic dysregulation biomarkers, with increased glucose, dyslipidemia and hepatic damage.
dc.description.departmentDepto. de Especialidades Clínicas Odontológicas
dc.description.departmentDepto. de Bioquímica y Biología Molecular
dc.description.departmentDepto. de Biología Celular
dc.description.facultyFac. de Odontología
dc.description.facultyFac. de Medicina
dc.description.refereedTRUE
dc.description.statuspub
dc.identifier.citationVirto L, Cano P, Jiménez-Ortega V, Fernández-Mateos P, González J, Esquifino AI, Sanz M. Obesity and periodontitis: An experimental study to evaluate periodontal and systemic effects of comorbidity. J Periodontol. 2018 Feb;89(2):176-185. doi: 10.1902/jop.2017.170355. Epub 2018 Feb 16.
dc.identifier.doi10.1902/jop.2017.170355
dc.identifier.essn1943-3670
dc.identifier.issn0022-3492
dc.identifier.officialurlhttps://doi.org/10.1902/jop.2017.170355
dc.identifier.relatedurlhttps://aap.onlinelibrary.wiley.com/doi/full/10.1902/jop.2017.170355
dc.identifier.urihttps://hdl.handle.net/20.500.14352/94163
dc.issue.number2
dc.journal.titleJournal of Periodontology
dc.language.isoeng
dc.page.final185
dc.page.initial176
dc.publisherThe American Academy of Periodontology
dc.rights.accessRightsrestricted access
dc.subject.cdu616.314.17-008.1
dc.subject.cdu616-056.25
dc.subject.cdu616.311.2-002
dc.subject.keywordImmunity
dc.subject.keywordCo-morbidity
dc.subject.keywordInflammation
dc.subject.keywordObesity
dc.subject.keywordPeriodontitis
dc.subject.keywordPorphyromonas gingivalis
dc.subject.ucmCiencias Biomédicas
dc.subject.ucmBioquímica (Química)
dc.subject.ucmBiología molecular (Biología)
dc.subject.unesco24 Ciencias de la Vida
dc.subject.unesco2403 Bioquímica
dc.subject.unesco2302.21 Biología Molecular
dc.titleObesity and periodontitis: An experimental study to evaluate periodontal and systemic effects of comorbidity
dc.typejournal article
dc.type.hasVersionVoR
dc.volume.number89
dspace.entity.typePublication
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