Evolución perinatal y a corto-medio plazo de los recién nacidos con crecimiento intrauterino restringido
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2024
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03/10/2023
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Universidad Complutense de Madrid
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Objetivo: Describir la evolución del cociente entre la tirosina quinasa 1 similar alfms soluble y el factor de crecimiento placentario (sFlt-1/PlGF) en las últimas 5 semanas antes del parto en gestaciones únicas complicadas con una restricción del crecimiento fetal (CIR) de inicio precoz, con o sin preeclampsia (PE).Métodos: Estudio prospectivo observacional de cohortes de casos de CIR precoz en los que se evaluó de forma seriada el cociente sFlt-1/PlGF en suero materno desde el diagnóstico hasta el parto. Las mediciones se realizaron a intervalos semanales y dentro de las últimas 48 h antes del nacimiento. Se calcularon los valores absolutos y el aumento porcentual entre los intervalos de tiempo, y se usaron los puntos de corte descritos anteriormente de 38 (sospecha de PE), 85 (ayuda al diagnóstico de PE) y 655(alto riesgo de parto inminente) para el análisis del cociente sFlt-1/PlGF. Comparamos los hallazgos entre los casos con CIR precoz aislado (n = 37) y aquellos que además desarrollaron PE (n = 36)...
Objective: To describe the evolution of soluble fms-like tyrosine kinase-1 to placental growth factor (sFlt-1/PlGF) ratio in the last 5 weeks prior to delivery in singleton pregnancy complicated by early-onset fetal growth restriction (FGR), with or without pre-eclampsia (PE).Methods: This was a prospective observational cohort study of early-onset FGR cases that underwent serial assessment of maternal serum sFlt-1/PlGF ratio from diagnosis to delivery. Measurements were made at weekly intervals and within the last 48 h before birth. Absolute values and percentage increase between time intervals were computed, and previously described cut-off values of 38 (suspicion of PE), 85 (aids diagnosis of PE) and 655 (high risk for imminent delivery) were used for analysis of the sFlt-1/PlGF ratio. We compared findings between cases with early-onset FGR only (n =37) and those that additionally developed PE (n = 36)...
Objective: To describe the evolution of soluble fms-like tyrosine kinase-1 to placental growth factor (sFlt-1/PlGF) ratio in the last 5 weeks prior to delivery in singleton pregnancy complicated by early-onset fetal growth restriction (FGR), with or without pre-eclampsia (PE).Methods: This was a prospective observational cohort study of early-onset FGR cases that underwent serial assessment of maternal serum sFlt-1/PlGF ratio from diagnosis to delivery. Measurements were made at weekly intervals and within the last 48 h before birth. Absolute values and percentage increase between time intervals were computed, and previously described cut-off values of 38 (suspicion of PE), 85 (aids diagnosis of PE) and 655 (high risk for imminent delivery) were used for analysis of the sFlt-1/PlGF ratio. We compared findings between cases with early-onset FGR only (n =37) and those that additionally developed PE (n = 36)...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Medicina, leída el 03-10-2023. Tesis formato europeo (compendio de artículos)