Nuevas técnicas de detección de Acanthamoeba : estudio de la eficacia de desinfección de las lentes de contacto
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2024
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14/04/2023
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Universidad Complutense de Madrid
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Abstract
Acanthamoeba spp. son protozoos de vida libre que se encuentran ampliamente distribuidos en el ambiente. En contacto con la superficie ocular puede comportarse como parásito provocando la queratitis por Acanthamoeba, considerada una de las patologías más graves a nivel ocular. La queratitis por Acanthamoeba cursa con dolor, fotofobia, daño epitelial, edema y si no se trata de manera adecuada, puede provocarla pérdida irreversible de la visión. Aproximadamente el 85% de los casos de queratitis amebiana está relacionado con el uso de lentes de contacto. El uso de las lentes durante el baño, las malas prácticas de higiene, así como su limpieza con agua de grifo incrementan el riesgo de infección. La limpieza y la desinfección de las lentes de contacto es esencial para evitar posibles infecciones corneales, por ello, existen numerosos estudios que tratan de valorar su eficacia frente a Acanthamoeba. Dada la ausencia de un enfoque estándar en los estudios existentes para valorar la eficacia de los productos de limpieza en la eliminación de Acanthamoeba, se dificulta la obtención de las mismas conclusiones...
Acanthamoeba spp. are free living protozoa widely distributed in the environment. Under favourable ocular conditions, it can behave as a parasite causing Acanthamoeba keratitis (AK), considered as one of the most serious ocular pathologies. Acanthamoeba keratitis is an ocular infection characterized by pain, photophobia, epithelial damage, and edema and may lead to irreversible loss of vision if not properly treated. In developed countries, it is estimated that 85% of AK cases occur in contact lens wearers. Poor hygiene practices, the exposure to water wearing the contact lens, ineffective contact lens disinfection solutions as well as the use of tapwater to clean them increases the risk of infection. Cleaning and disinfection of contact lenses is essential to prevent corneal related infections. For this reason, numerous studies have attempted to assess their effectiveness against Acanthamoeba. The lack of a standard approach to assess the disinfection commercial products efficacy against Acanthamoeba, makes difficult to obtain accurate conclusions...
Acanthamoeba spp. are free living protozoa widely distributed in the environment. Under favourable ocular conditions, it can behave as a parasite causing Acanthamoeba keratitis (AK), considered as one of the most serious ocular pathologies. Acanthamoeba keratitis is an ocular infection characterized by pain, photophobia, epithelial damage, and edema and may lead to irreversible loss of vision if not properly treated. In developed countries, it is estimated that 85% of AK cases occur in contact lens wearers. Poor hygiene practices, the exposure to water wearing the contact lens, ineffective contact lens disinfection solutions as well as the use of tapwater to clean them increases the risk of infection. Cleaning and disinfection of contact lenses is essential to prevent corneal related infections. For this reason, numerous studies have attempted to assess their effectiveness against Acanthamoeba. The lack of a standard approach to assess the disinfection commercial products efficacy against Acanthamoeba, makes difficult to obtain accurate conclusions...
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Tesis inédita de la Universidad Complutense de Madrid, Facultad de Óptica y Optometría, leída el 14-04-2023