Aviso: para depositar documentos, por favor, inicia sesión e identifícate con tu cuenta de correo institucional de la UCM con el botón MI CUENTA UCM. No emplees la opción AUTENTICACIÓN CON CONTRASEÑA
 

Epigenetic Deregulation of the Histone Methyltransferase KMT5B Contributes to Malignant Transformation in Glioblastoma

Simple item page
dc.contributor.authorLópez, Virginia
dc.contributor.authorTejedor, Juan Ramón
dc.contributor.authorCarella, Antonella
dc.contributor.authorGarcía, María G.
dc.contributor.authorSantamarina-Ojeda, Pablo
dc.contributor.authorPérez, Raúl F.
dc.contributor.authorMangas, Cristina
dc.contributor.authorUrdinguio, Rocío G.
dc.contributor.authorAranburu, Aitziber
dc.contributor.authorde la Nava, Daniel
dc.contributor.authorCorte-Torres, María D.
dc.contributor.authorAstudillo, Aurora
dc.contributor.authorMollejo, Manuela
dc.contributor.authorMeléndez, Bárbara
dc.contributor.authorFernández, Agustín F.
dc.contributor.authorFraga, Mario F.
dc.date.accessioned2024-10-31T18:56:45Z
dc.date.available2024-10-31T18:56:45Z
dc.date.issued2021-08-10
dc.descriptionFUNDING This research was funded by the Health Institute Carlos III (Plan Nacional de I+D+I) cofounding FEDER (PI15/00892 and PI18/01527 to MF and AF); the Government of the Principality of Asturias PCTI-Plan de Ciencia, Tecnología e Innovación de Asturias co-funding 2018–2022/FEDER (IDI/2018/146 to MF); AECC (PROYE18061FERN to MF); FGCSIC (0348_CIE_6_E to MF); Severo Ochoa Program BP17-165 to PS-O and BP17-114 to RP); the Ministry of Economy and Competitiveness of Spain (VL, Juan de la Cierva fellowship IJCI-2015-23316; JT, Juan de la Cierva fellowship FJCI-2015-26965); FICYT (AC and MG); FINBA-ISPA (VL); and IUOPA (VL and CM). The IUOPA is supported by the Obra Social Cajastur-Liberbank, Spain.
dc.description.abstractGlioblastoma multiforme (GBM) is the most common and aggressive type of brain tumor in adulthood. Epigenetic mechanisms are known to play a key role in GBM although the involvement of histone methyltransferase KMT5B and its mark H4K20me2 has remained largely unexplored. The present study shows that DNA hypermethylation and loss of DNA hydroxymethylation is associated with KMT5B downregulation and genome-wide reduction of H4K20me2 levels in a set of human GBM samples and cell lines as compared with non-tumoral specimens. Ectopic overexpression of KMT5B induced tumor suppressor-like features in vitro and in a mouse tumor xenograft model, as well as changes in the expression of several glioblastoma-related genes. H4K20me2 enrichment was found immediately upstream of the promoter regions of a subset of deregulated genes, thus suggesting a possible role for KMT5B in GBM through the epigenetic modulation of key target cancer genes.
dc.description.agreementMinisterio de Ciencias y Innovación (Juan de la Cierva)
dc.description.departmentDepto. de Bioquímica y Biología Molecular
dc.description.facultyFac. de Veterinaria
dc.description.refereedTRUE
dc.description.sponsorshipInstituto de Salud Carlos III
dc.description.sponsorshipGobierno del Principado de Asturias
dc.description.sponsorshipMinisterio de Economía y Competitividad de España
dc.description.statuspub
dc.identifier.citationLópez, V., Tejedor, J. R., Carella, A., García, M. G., Santamarina-Ojeda, P., Pérez, R. F., Mangas, C., Urdinguio, R. G., Aranburu, A., de la Nava, D., Corte-Torres, M. D., Astudillo, A., Mollejo, M., Meléndez, B., Fernández, A. F., & Fraga, M. F. (2021). Epigenetic Deregulation of the Histone Methyltransferase KMT5B Contributes to Malignant Transformation in Glioblastoma. Frontiers in cell and developmental biology, 9, 671838. https://doi.org/10.3389/fcell.2021.671838
dc.identifier.doi10.3389/fcell.2021.671838
dc.identifier.essn2296-634X
dc.identifier.officialurlhttps://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2021.671838/full
dc.identifier.pmid34447744
dc.identifier.relatedurlhttps://pubmed.ncbi.nlm.nih.gov/34447744/
dc.identifier.urihttps://hdl.handle.net/20.500.14352/109897
dc.journal.titleFrontiers in Cell and Developmental Biology
dc.language.isoeng
dc.page.initial671838
dc.publisherFrontiers Media
dc.relation.projectIDinfo:eu-repo/grantAgreement/MICINN//BFU2008-00892/ES/REDES GENETICAS REGULADORAS EN EL EPITELIO DEL ESCUTELO DURANTE LA GERMINACION/
dc.relation.projectIDinfo:eu-repo/grantAgreement/MICINN//ECO2008-01527/ES/DE COMO LAS CORPORACIONES ENTRAN Y NAVEGAN ENTRE DIFERENTES ESPACIOS DE REDES: UN ESTUDIO LONGITUDINAL/
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//RYC-2015-18061/ES/RYC-2015-18061/
dc.relation.projectIDinfo:eu-repo/grantAgreement/Gobierno del Principado de Asturias//2006%2F000348/ES/DANA SOFTWARE INFORMATICA CALIDAD/
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//IJCI-2015-23316/ES/IJCI-2015-23316/
dc.rightsAttribution 4.0 Internationalen
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.cdu577.2
dc.subject.keywordEpigenetics
dc.subject.keywordGlioblastoma
dc.subject.keywordHistone methyltransferase
dc.subject.keywordHistone posttranslational modification
dc.subject.keywordTumor suppresso
dc.subject.ucmBiología molecular (Biología)
dc.subject.unesco2415 Biología Molecular
dc.titleEpigenetic Deregulation of the Histone Methyltransferase KMT5B Contributes to Malignant Transformation in Glioblastoma
dc.typejournal article
dc.type.hasVersionAM
dc.volume.number9
dspace.entity.typePublication

Download

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
2021_Lopez_Frontiers.pdf
Size:
3.08 MB
Format:
Adobe Portable Document Format
downoload Download

Collections

Artículos