Effect of Nanoclustering and Dipolar Interactions in Heat Generation for Magnetic Hyperthermia

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dc.contributor.authorCoral Coral, Diego Fernando
dc.contributor.authorMendoza Zélis, Pedro
dc.contributor.authorMarciello, Marzia
dc.contributor.authorPuerto Morales, María Del
dc.contributor.authorCraievich, Aldo
dc.contributor.authorSánchez, Francisco Homero
dc.contributor.authorFernández van Raap, Marcela Beatriz
dc.date.accessioned2024-02-09T10:03:42Z
dc.date.available2024-02-09T10:03:42Z
dc.date.issued2016-01-26
dc.description.abstractBiomedical magnetic colloids commonly used in magnetic hyperthermia experiments often display a bidisperse structure, i.e., are composed of stable nanoclusters coexisting with well-dispersed nanoparticles. However, the influence of nanoclusters in the optimization of colloids for heat dissipation is usually excluded. In this work, bidisperse colloids are used to analyze the effect of nanoclustering and long-range magnetic dipolar interaction on the magnetic hyperthermia efficiency. Two kinds of colloids, composed of magnetite cores with mean sizes of around 10 and 18 nm, coated with oleic acid and dispersed in hexane, and coated with meso-2,3-dimercaptosuccinic acid and dispersed in water, were analyzed. Small-angle X-ray scattering was applied to thoroughly characterize nanoparticle structuring. We proved that the magnetic hyperthermia performances of nanoclusters and single nanoparticles are distinctive. Nanoclustering acts to reduce the specific heating efficiency whereas a peak against concentration appears for the well-dispersed component. Our experiments show that the heating efficiency of a magnetic colloid can increase or decrease when dipolar interactions increase and that the colloid concentration, i.e., dipolar interaction, can be used to improve magnetic hyperthermia. We have proven that the power dissipated by an ensemble of dispersed magnetic nanoparticles becomes a nonextensive property as a direct consequence of the long-range nature of dipolar interactions. This knowledge is a key point in selecting the correct dose that has to be injected to achieve the desired outcome in intracellular magnetic hyperthermia therapy.eng
dc.description.departmentDepto. de Química en Ciencias Farmacéuticas
dc.description.facultyFac. de Farmacia
dc.description.refereedTRUE
dc.description.sponsorshipConsejo Nacional de Investigaciones Científicas y Técnicas (Argentina)
dc.description.sponsorshipUniversidad Nacional de La Plata (Argentina)
dc.description.sponsorshipEuropean Commission
dc.description.sponsorshipMinisterio de Economía, Comercio y Empresa (España)
dc.description.sponsorshipLaboratorio Nacional de Luz Sincrotrón (Brasil)
dc.description.statuspub
dc.identifier.citationCoral DF, Mendoza Zélis P, Marciello M, Morales MDP, Craievich A, Sánchez FH, et al. Effect of Nanoclustering and Dipolar Interactions in Heat Generation for Magnetic Hyperthermia. Langmuir 2016;32:1201–13. https://doi.org/10.1021/acs.langmuir.5b03559.
dc.identifier.doi10.1021/acs.langmuir.5b03559
dc.identifier.essn1520-5827
dc.identifier.issn0743-7463
dc.identifier.officialurlhttps://doi.org/10.1021/acs.langmuir.5b03559
dc.identifier.urihttps://hdl.handle.net/20.500.14352/100799
dc.issue.number5
dc.journal.titleLangmuir
dc.language.isoeng
dc.relation.projectIDinfo:eu-repo/grantAgreement/PIP0720
dc.relation.projectIDinfo:eu-repo/grantAgreement/X11/680
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP/262943
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/60448
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO/MAT2014-52069-R
dc.relation.projectIDinfo:eu-repo/grantAgreement/D01BSAXS2-14429
dc.relation.projectIDinfo:eu-repo/grantAgreement/16920
dc.rights.accessRightsrestricted access
dc.subject.cdu615:54
dc.subject.cdu615.31
dc.subject.ucmQuímica
dc.subject.unesco23 Química
dc.titleEffect of Nanoclustering and Dipolar Interactions in Heat Generation for Magnetic Hyperthermia
dc.typejournal article
dc.type.hasVersionAM
dc.volume.number32
dspace.entity.typePublication
relation.isAuthorOfPublicationb66b3a6e-1c2b-4ffe-b371-afb239918774
relation.isAuthorOfPublication.latestForDiscoveryb66b3a6e-1c2b-4ffe-b371-afb239918774
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