The influence of meibomian gland loss on ocular surface clinical parameters

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dc.contributor.authorRico del Viejo, Laura
dc.contributor.authorBenítez del Castillo, José Manuel
dc.contributor.authorGómez Sanz, Fernando Javier
dc.contributor.authorGarcía Montero, María
dc.contributor.authorLlorens Quintana, Clara
dc.contributor.authorMadrid Costa, David
dc.date.accessioned2023-06-17T13:22:11Z
dc.date.available2023-06-17T13:22:11Z
dc.date.issued2019-04-10
dc.descriptionReceived 19 December 2018, Revised 31 March 2019, Accepted 3 April 2019, Available online 10 April 2019.
dc.description.abstractPurpose: To assess the relationship between the meibomian gland loss (MGL) and relevant ocular surface clinical parameters as well as the influence of age in this relationship. Methods: A total of 161 participants (mean age; 42±17 years) were enrolled in this study. Infrared meibography was performed using Keratograph 5M (K5M; Oculus GmbH, Wetzlar). Participants were divided into five groups according to total meiboscore and the ocular surface parameters of each MGL group were studied. In addition, the relationship between MGL and the ocular surface parameters was established including age as covariant. Results: Both eyelids were taken into account since no association between the MGL from upper and lower eyelid was found (k value=0.2; p=0.3) despite they were significantly correlated (r= 0.3; p<0.001). No statistically significant differences were found in symptomatology among different MGL groups. Statistically significant differences were found among MGL groups in tear osmolarity (p=0.02), bulbar redness (p=0.04), corneal and conjunctival staining (p=0.01 and p=0.004, respectively). Despite this, only corneal staining showed a significant correlation with MGL when age was covariant (r=0.2; p=0.04). Conclusions: MGL higher than 50% seems to be accompanied by signs on the ocular surface. Furthermore, age demonstrated to be a relevant factor when assessing MGL. For this reason, future studies should compare age-matched groups in order to know the contribution of the MGL on the ocular surface and establish valid cut-off values for dry eye diagnosis.
dc.description.departmentDepto. de Optometría y Visión
dc.description.facultyFac. de Óptica y Optometría
dc.description.refereedTRUE
dc.description.sponsorshipUnión Europea. H2020
dc.description.statuspub
dc.eprint.idhttps://eprints.ucm.es/id/eprint/55124
dc.identifier.doi10.1016/j.clae.2019.04.004
dc.identifier.issn1367-0484
dc.identifier.officialurlhttps://doi.org/10.1016/j.clae.2019.04.004
dc.identifier.relatedurlhttps://www.sciencedirect.com/science/article/pii/S1367048418310610?via%3Dihub#!
dc.identifier.urihttps://hdl.handle.net/20.500.14352/13267
dc.journal.titleContact Lens and Anterior Eye
dc.language.isoeng
dc.publisherElsevier
dc.relation.projectIDEDEN (642760)
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 España
dc.rights.accessRightsopen access
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subject.cdu617.764
dc.subject.cdu617.71/.77
dc.subject.cdu617.776
dc.subject.keywordMeibomian gland loss
dc.subject.keywordInfrared Meibography
dc.subject.keywordOcular surface
dc.subject.keywordTear film
dc.subject.keywordSymptomatology
dc.subject.keywordAge
dc.subject.ucmAnatomía ocular
dc.subject.ucmÓptica fisiológica
dc.subject.ucmTécnicas de la imagen
dc.titleThe influence of meibomian gland loss on ocular surface clinical parameters
dc.typejournal article
dspace.entity.typePublication
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relation.isAuthorOfPublication9b637d56-481e-40c6-a0e6-eb4de92e663c
relation.isAuthorOfPublication383ca857-3af5-4787-8717-d278082d1d13
relation.isAuthorOfPublication.latestForDiscoverybb97b42a-c73c-45da-b3b5-27f01b082e9d
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